https://wikimd.com/index.php?action=history&feed=atom&title=Platelet-activating_factor_receptor Platelet-activating factor receptor - Revision history 2026-04-22T02:39:54Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Platelet-activating_factor_receptor&diff=6517613&oldid=prev Prab: CSV import 2025-03-17T23:00:02Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 23:00, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l31">Line 31:</td> <td colspan="2" class="diff-lineno">Line 31:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> <!-- diff cache key wikimd4:diff:1.41:old-6258990:rev-6517613:php=table --> </table> Prab https://wikimd.com/index.php?title=Platelet-activating_factor_receptor&diff=6258990&oldid=prev Prab: CSV import 2025-02-10T21:07:03Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:07, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l30">Line 30:</td> <td colspan="2" class="diff-lineno">Line 30:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Allergy}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{Allergy}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> <!-- diff cache key wikimd4:diff:1.41:old-5380043:rev-6258990:php=table --> </table> Prab https://wikimd.com/index.php?title=Platelet-activating_factor_receptor&diff=5380043&oldid=prev Prab: CSV import 2024-03-10T07:07:02Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Platelet-activating factor receptor&#039;&#039;&#039; (&#039;&#039;&#039;PAFR&#039;&#039;&#039;) is a [[protein]] that in humans is encoded by the PTAFR [[gene]]. PAFR is a member of the [[G protein-coupled receptor]] family and plays a crucial role in [[inflammation]] and [[allergy]] responses.<br /> <br /> ==Structure==<br /> The PAFR protein is a cell surface receptor that is coupled to the [[G protein]] signaling pathway. It is composed of seven transmembrane domains, a characteristic feature of G protein-coupled receptors. The gene encoding PAFR is located on chromosome 1 in humans.<br /> <br /> ==Function==<br /> PAFR is primarily involved in mediating the effects of the lipid mediator [[platelet-activating factor]] (PAF). PAF is a potent [[phospholipid]] mediator that has diverse physiological effects, including the induction of [[inflammation]], [[platelet aggregation]], and [[vasodilation]]. Binding of PAF to PAFR triggers a cascade of intracellular events, leading to the activation of various cellular responses.<br /> <br /> ==Clinical significance==<br /> Alterations in PAFR function have been implicated in a variety of diseases, including [[asthma]], [[allergy]], [[sepsis]], and [[cancer]]. In particular, overexpression of PAFR has been observed in several types of cancer, suggesting a potential role in tumor progression.<br /> <br /> ==Research==<br /> Research into PAFR has focused on understanding its role in disease processes and developing therapeutic strategies to modulate its activity. Several PAFR antagonists have been developed and are currently under investigation for their potential use in treating diseases associated with PAFR overactivity.<br /> <br /> ==See also==<br /> * [[G protein-coupled receptor]]<br /> * [[Platelet-activating factor]]<br /> * [[Inflammation]]<br /> * [[Allergy]]<br /> <br /> [[Category:G protein-coupled receptors]]<br /> [[Category:Human proteins]]<br /> [[Category:Inflammation]]<br /> [[Category:Allergy]]<br /> [[Category:Medicine]]<br /> <br /> {{G protein-coupled receptors}}<br /> {{Human proteins}}<br /> {{Inflammation}}<br /> {{Allergy}}<br /> {{medicine-stub}}</div> Prab