https://wikimd.com/index.php?action=history&feed=atom&title=Platelet-activating_factor 2026-04-20T20:59:28Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Platelet-activating_factor&diff=6303584&oldid=prev 2025-02-16T22:12:01Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:12, 16 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l29">Line 29:</td> <td colspan="2" class="diff-lineno">Line 29:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immunology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Immunology]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pharmacology]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Platelet-activating_factor.svg</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

Prab https://wikimd.com/index.php?title=Platelet-activating_factor&diff=5290315&oldid=prev 2024-02-25T14:30:35Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Platelet-activating factor&#039;&#039;&#039; (PAF) is a potent [[lipid]] mediator involved in many [[physiological]] and [[pathological]] processes. It is a type of [[phospholipid]] that has been implicated in a variety of biological functions, including [[inflammation]], [[allergy]], [[shock]], and [[thrombosis]].<br /> <br /> == Structure ==<br /> PAF is a unique [[glycerophospholipid]] with a short, sn-2 acetyl group and a long, sn-1 alkyl group. The sn-3 position is occupied by a [[phosphocholine]] group. This structure is essential for its biological activity.<br /> <br /> == Biosynthesis ==<br /> PAF is synthesized by a variety of cells, including [[platelets]], [[neutrophils]], [[monocytes]], [[macrophages]], and [[endothelial cells]]. The biosynthesis of PAF involves two main pathways: the &#039;&#039;de novo&#039;&#039; pathway and the remodeling pathway.<br /> <br /> == Functions ==<br /> PAF has a wide range of biological functions. It is a potent [[platelet]] activator and aggregator, hence its name. It also has pro-inflammatory effects, stimulating the release of [[histamine]] from [[mast cells]] and [[basophils]], and promoting the adhesion and migration of [[leukocytes]]. In addition, PAF plays a role in [[vascular permeability]], [[bronchoconstriction]], and [[immune response]].<br /> <br /> == Pathological roles ==<br /> PAF has been implicated in a variety of pathological conditions, including [[asthma]], [[allergic reactions]], [[septic shock]], [[ischemia]], and [[thrombosis]]. It is also involved in the pathogenesis of [[atherosclerosis]] and [[cancer]].<br /> <br /> == Therapeutic potential ==<br /> Given its involvement in many pathological processes, PAF has been the target of numerous therapeutic interventions. PAF antagonists have been developed and tested for their efficacy in treating conditions such as [[asthma]], [[allergic reactions]], and [[septic shock]].<br /> <br /> == See also ==<br /> * [[Phospholipid]]<br /> * [[Inflammation]]<br /> * [[Thrombosis]]<br /> * [[Asthma]]<br /> * [[Allergic reactions]]<br /> <br /> {{stub}}<br /> <br /> [[Category:Biochemistry]]<br /> [[Category:Cell biology]]<br /> [[Category:Immunology]]<br /> [[Category:Pharmacology]]</div>

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