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<p></p> <p><b>New page</b></p><div>[[File:Pivmecillinam.svg|thumb|right|Structure of Pivmecillinam]]<br /> <br /> &#039;&#039;&#039;Pivmecillinam&#039;&#039;&#039; ([[International Nonproprietary Name|INN]]) or &#039;&#039;&#039;amdinocillin pivoxil&#039;&#039;&#039; ([[United States Approved Name|USAN]]), traded under the names &#039;&#039;&#039;Selexid&#039;&#039;&#039;, &#039;&#039;&#039;Penomax&#039;&#039;&#039;, and &#039;&#039;&#039;Coactabs&#039;&#039;&#039;, is an orally administrable [[prodrug]] of [[mecillinam]], an extended-spectrum [[penicillin]] [[antibiotic]]. Pivmecillinam is classified as the [[pivaloyloxymethyl]] [[carboxylate ester|ester]] of mecillinam. Notably, neither of these drugs has approval for use within the United States.<br /> <br /> The therapeutic applications of Pivmecillinam are restricted mainly to combat [[Gram-negative bacteria]]. Its primary indication is in treating lower [[urinary tract infection]]s. Since the 1970s, it has been a widely recognized treatment in the [[Nordic countries]]. Due to its effectiveness, it has been recommended as the [[first-line treatment|first-line drug]] in the empirical management of acute [[cystitis]].<br /> <br /> ===Activity===<br /> {{See also|Mecillinam}}<br /> [[Image:Mecillinam.svg|thumb|270px|left|[[Skeletal formula]] of mecillinam, the bioactive form of pivmecillinam]]<br /> <br /> ===Adverse effects===<br /> {{see also|Beta-lactam antibiotic#Adverse effects|l1=Beta-lactam antibiotic: Adverse effects}}<br /> Like its penicillin counterparts, pivmecillinam has a similar [[adverse drug reaction|adverse effect]] profile. Common side effects associated with its use include [[rash]] and gastrointestinal disturbances, with symptoms such as [[nausea]] and [[vomiting]] being prevalent.<br /> <br /> It&#039;s imperative to note that prodrugs yielding [[pivalic acid]] upon metabolism in the body, like pivmecillinam, [[pivampicillin]], and [[cefditoren pivoxil]], are known to cause a decrease in the body&#039;s [[carnitine]] levels.<br /> <br /> ==References==<br /> {{Reflist}}<br /> <br /> ==See also==<br /> * [[Prodrug]]<br /> * [[Beta-lactam antibiotics]]<br /> * {{Beta-lactam antibiotics}}<br /> [[Category:Beta-lactam antibiotics]]<br /> [[Category:Azepanes]]<br /> [[Category:Prodrugs]] <br /> {{pharma-stub}}</div>

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