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	Piroplasmida is a class of parasitic protozoa that belongs to the phylum Apicomplexa. These organisms are commonly found in the blood cells of vertebrates, including mammals, birds, and reptiles. Piroplasmida is known for causing a disease called piroplasmosis, which can have severe consequences for the infected host.		== Piroplasmida ==

	~~== Taxonomy ==~~		[[File:Babiesa_spp.jpg\|thumb\|right\|Babesia spp. parasites within red blood cells]]
	Piroplasmida is a class within the phylum Apicomplexa, which also includes other parasitic protozoa such as Plasmodium, the causative agent of malaria. Within the class Piroplasmida, there are two main families: ~~Babesiidae and Theileriidae~~. ~~The Babesiidae family includes genera such as~~ Babesia ~~and Theileria, while the Theileriidae family includes the genus Theileria~~.

	~~== Morphology and Life Cycle ==~~		'''Piroplasmida''' is an order of parasitic [[protozoa]] within the phylum [[Apicomplexa]]. These organisms are primarily known for their role as blood parasites in various vertebrate hosts, including mammals, birds, and reptiles. The most well-known genera within this order are ''[[Babesia]]'' and ''[[Theileria]]'', both of which are significant due to their impact on animal health and their zoonotic potential.
	Piroplasmida organisms ~~have a complex life cycle that involves both~~ vertebrate and ~~invertebrate hosts~~. ~~In the vertebrate host, the parasites reside~~ within ~~the red blood cells~~, ~~where they undergo asexual reproduction. This results in the formation~~ of ~~merozoites,~~ which ~~can further invade other red blood cells or differentiate into sexual forms called gametocytes~~.

	When a tick or other blood-feeding arthropod feeds on an infected vertebrate, it ingests the gametocytes along with the blood. Within the tick's gut, the gametocytes undergo sexual reproduction, resulting in the formation of zygotes. These zygotes then develop into motile forms called kinetes, which migrate to the salivary glands of the tick. When the tick feeds on another vertebrate, it injects the kinetes into the host's bloodstream, completing the transmission cycle.		== Characteristics ==

	~~== Pathogenesis ==~~		Piroplasms are characterized by their small, pear-shaped forms when observed under a microscope. They are obligate intracellular parasites, meaning they must live within the cells of their host to survive and reproduce. The life cycle of piroplasms typically involves two hosts: a vertebrate host, where they infect red blood cells, and an arthropod vector, usually a tick, where sexual reproduction occurs.
	~~Piroplasmida parasites can cause significant damage to~~ their ~~vertebrate hosts~~. ~~The~~ parasites ~~invade and multiply~~ within the ~~red blood~~ cells~~, leading~~ to ~~their destruction~~ and ~~subsequent anemia~~. The host~~'s immune response to the infection can also contribute to tissue damage~~ and ~~inflammation~~.

	The ~~severity~~ of ~~piroplasmosis varies depending on~~ the ~~species of~~ the ~~parasite and~~ the host'~~s immune response~~. ~~In some cases~~, ~~the infection~~ can ~~be mild or even asymptomatic~~. ~~However~~, in ~~other cases~~, ~~it can lead to severe symptoms such as~~ fever, ~~lethargy,~~ anemia, jaundice, ~~and organ failure. Piroplasmosis~~ can ~~be particularly dangerous~~ in ~~young or immunocompromised animals~~.		== Life Cycle ==

			The life cycle of piroplasms involves several stages:

			* '''Sporozoites''': These are the infective forms transmitted by the tick vector to the vertebrate host during a blood meal.
			* '''Trophozoites''': Once inside the host, sporozoites invade red blood cells and develop into trophozoites.
			* '''Merozoites''': Trophozoites multiply asexually to form merozoites, which can infect new red blood cells.
			* '''Gametocytes''': Some merozoites develop into gametocytes, which are taken up by a tick during feeding.
			* '''Zygote and Sporogony''': In the tick, gametocytes fuse to form a zygote, which undergoes sporogony to produce new sporozoites.

			== Pathogenicity ==

			Piroplasms can cause significant disease in their hosts. ''Babesia'' species are responsible for [[babesiosis]], a disease characterized by fever, hemolytic anemia, and jaundice. In cattle, ''Theileria'' species can cause [[theileriosis]], leading to severe economic losses in the livestock industry.

			== Transmission ==

			Transmission of piroplasms occurs primarily through tick bites. Different species of ticks serve as vectors for different piroplasm species. For example, ''Babesia microti'' is transmitted by the [[Ixodes scapularis]] tick, which is also a vector for [[Lyme disease]].

	== Diagnosis and Treatment ==		== Diagnosis and Treatment ==
	Diagnosing piroplasmosis typically involves microscopic examination of blood smears, where the presence of piroplasmida parasites can be observed within the red blood cells. Molecular techniques such as polymerase chain reaction (PCR) can also be used for more accurate detection and identification of the parasite species.

	Treatment ~~of piroplasmosis usually~~ involves the ~~administration~~ of antiprotozoal drugs such as ~~imidocarb dipropionate or diminazene aceturate. Supportive care, including blood transfusions~~ and ~~fluid therapy, may also be necessary in severe cases~~.		Diagnosis of piroplasm infections is typically made through microscopic examination of blood smears, where the parasites can be seen within red blood cells. Molecular techniques, such as [[PCR]], are also used for more accurate identification. Treatment often involves the use of antiprotozoal drugs, such as [[atovaquone]] and [[azithromycin]] for babesiosis.

	== ~~Prevention and Control~~ ==		== Related Pages ==
	Preventing piroplasmosis primarily involves controlling the tick population and minimizing exposure to infected ticks. This can be achieved through regular tick control measures, such as the use of acaricides and tick repellents on both animals and their environment. Vaccines against specific piroplasmida species have also been developed for certain animal species.

	~~== See Also ==~~
	* [[Apicomplexa]]
	* [[Babesia]]		* [[Babesia]]
	* [[Theileria]]		* [[Theileria]]
	* [[~~Piroplasmosis~~]]		* [[Apicomplexa]]
			* [[Tick]]
			* [[Babesiosis]]
			* [[Theileriosis]]

	~~== References ==~~		[[Category:Apicomplexa]]
	~~1. Uilenberg, G. (2006). Babesia—a historical overview. Veterinary Parasitology, 138(1-2), 3-10.~~		[[Category:Parasitic diseases]]
	2. Criado-Fornelio, A., Martinez-Marcos, A., Buling-Sarana, A., Barba-Carretero, J. C. (2003). Molecular studies on Babesia, Theileria and Hepatozoon in southern Europe. Part I. Epizootiological aspects. Veterinary Parasitology, 113(3-4), 189-201.
	~~3. Shkap, V., Pipano, E., & Fish, L. (2002). Vaccination of cattle against Theileria annulata using a soluble parasite antigen preparation. Veterinary Parasitology, 105(4), 307-323.~~
	~~{{dictionary-stub1}}~~

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Piroplasmida is a class of parasitic protozoa that belongs to the phylum Apicomplexa. These organisms are commonly found in the blood cells of vertebrates, including mammals, birds, and reptiles. Piroplasmida is known for causing a disease called piroplasmosis, which can have severe consequences for the infected host.

== Taxonomy ==
Piroplasmida is a class within the phylum Apicomplexa, which also includes other parasitic protozoa such as Plasmodium, the causative agent of malaria. Within the class Piroplasmida, there are two main families: Babesiidae and Theileriidae. The Babesiidae family includes genera such as Babesia and Theileria, while the Theileriidae family includes the genus Theileria.

== Morphology and Life Cycle ==
Piroplasmida organisms have a complex life cycle that involves both vertebrate and invertebrate hosts. In the vertebrate host, the parasites reside within the red blood cells, where they undergo asexual reproduction. This results in the formation of merozoites, which can further invade other red blood cells or differentiate into sexual forms called gametocytes.

When a tick or other blood-feeding arthropod feeds on an infected vertebrate, it ingests the gametocytes along with the blood. Within the tick's gut, the gametocytes undergo sexual reproduction, resulting in the formation of zygotes. These zygotes then develop into motile forms called kinetes, which migrate to the salivary glands of the tick. When the tick feeds on another vertebrate, it injects the kinetes into the host's bloodstream, completing the transmission cycle.

== Pathogenesis ==
Piroplasmida parasites can cause significant damage to their vertebrate hosts. The parasites invade and multiply within the red blood cells, leading to their destruction and subsequent anemia. The host's immune response to the infection can also contribute to tissue damage and inflammation.

The severity of piroplasmosis varies depending on the species of the parasite and the host's immune response. In some cases, the infection can be mild or even asymptomatic. However, in other cases, it can lead to severe symptoms such as fever, lethargy, anemia, jaundice, and organ failure. Piroplasmosis can be particularly dangerous in young or immunocompromised animals.

== Diagnosis and Treatment ==
Diagnosing piroplasmosis typically involves microscopic examination of blood smears, where the presence of piroplasmida parasites can be observed within the red blood cells. Molecular techniques such as polymerase chain reaction (PCR) can also be used for more accurate detection and identification of the parasite species.

Treatment of piroplasmosis usually involves the administration of antiprotozoal drugs such as imidocarb dipropionate or diminazene aceturate. Supportive care, including blood transfusions and fluid therapy, may also be necessary in severe cases.

== Prevention and Control ==
Preventing piroplasmosis primarily involves controlling the tick population and minimizing exposure to infected ticks. This can be achieved through regular tick control measures, such as the use of acaricides and tick repellents on both animals and their environment. Vaccines against specific piroplasmida species have also been developed for certain animal species.

== See Also ==
* [[Apicomplexa]]
* [[Babesia]]
* [[Theileria]]
* [[Piroplasmosis]]

== References ==
1. Uilenberg, G. (2006). Babesia—a historical overview. Veterinary Parasitology, 138(1-2), 3-10.
2. Criado-Fornelio, A., Martinez-Marcos, A., Buling-Sarana, A., Barba-Carretero, J. C. (2003). Molecular studies on Babesia, Theileria and Hepatozoon in southern Europe. Part I. Epizootiological aspects. Veterinary Parasitology, 113(3-4), 189-201.
3. Shkap, V., Pipano, E., & Fish, L. (2002). Vaccination of cattle against Theileria annulata using a soluble parasite antigen preparation. Veterinary Parasitology, 105(4), 307-323.
{{dictionary-stub1}}

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