https://wikimd.org/index.php?action=history&feed=atom&title=Pimobendan 2026-04-26T00:23:03Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Pimobendan&diff=6335779&oldid=prev 2025-02-20T01:41:24Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 01:41, 20 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l46">Line 46:</td> <td colspan="2" class="diff-lineno">Line 46:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Pimobendan skeletal.svg|Pimobendan skeletal structure</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Pimobendan.jpg|Pimobendan</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:Pimobendan synthesis.svg|Pimobendan synthesis</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=Pimobendan&diff=5874531&oldid=prev 2024-05-30T04:35:57Z

<p>CSV import</p> <p><b>New page</b></p><div>[[file:Pimobendan_skeletal.svg|thumb|Pimobendan skeletal]] [[file:Pimobendan_synthesis.svg|thumb|Pimobendan synthesis|left]] &#039;&#039;&#039;Pimobendan&#039;&#039;&#039; is a veterinary medication used in the management of heart failure in dogs. It is classified as an inodilator, which means it has both inotropic and vasodilatory effects. Pimobendan is commonly prescribed for conditions such as [[congestive heart failure]] and [[dilated cardiomyopathy]].<br /> <br /> ==Mechanism of Action==<br /> Pimobendan works by inhibiting phosphodiesterase III, an enzyme that breaks down cyclic AMP (cAMP). By inhibiting this enzyme, pimobendan increases the levels of cAMP within cardiac muscle cells, leading to enhanced myocardial contractility. Additionally, pimobendan sensitizes the heart to calcium, further improving cardiac output. The vasodilatory effect is achieved through the relaxation of vascular smooth muscle, which reduces the workload on the heart.<br /> <br /> ==Indications==<br /> Pimobendan is primarily indicated for the treatment of:<br /> * [[Congestive heart failure]] due to [[mitral valve disease]] or [[dilated cardiomyopathy]] in dogs.<br /> * Preclinical [[dilated cardiomyopathy]] in large breed dogs.<br /> <br /> ==Dosage and Administration==<br /> The dosage of pimobendan is typically determined by the weight of the dog and the severity of the condition. It is usually administered orally, and the dosage may be adjusted based on the dog&#039;s response to the treatment.<br /> <br /> ==Side Effects==<br /> Common side effects of pimobendan may include:<br /> * [[Gastrointestinal upset]], such as vomiting and diarrhea.<br /> * [[Lethargy]].<br /> * [[Loss of appetite]].<br /> <br /> In rare cases, more severe side effects such as [[arrhythmias]] may occur.<br /> <br /> ==Contraindications==<br /> Pimobendan should not be used in dogs with:<br /> * [[Hypertrophic cardiomyopathy]].<br /> * Aortic stenosis.<br /> * Known hypersensitivity to the drug.<br /> <br /> ==Related Pages==<br /> * [[Congestive heart failure]]<br /> * [[Dilated cardiomyopathy]]<br /> * [[Mitral valve disease]]<br /> * [[Inotropic agents]]<br /> * [[Vasodilators]]<br /> <br /> ==References==<br /> {{Reflist}}<br /> <br /> ==External Links==<br /> {{Commons category|Pimobendan}}<br /> <br /> [[Category:Veterinary drugs]]<br /> [[Category:Cardiology]]<br /> [[Category:Inotropic agents]]<br /> [[Category:Vasodilators]]<br /> [[Category:Phosphodiesterase inhibitors]]<br /> <br /> {{medicine-stub}}</div>

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