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	'''Piminodine''' is ~~an [[~~opioid]] [[~~analgesic~~]] ~~that~~ is ~~an analog~~ of [[~~pethidine~~]] ~~(meperidine)~~. It was ~~developed~~ by ~~[[Hoffmann~~-~~La Roche]] in the 1950s~~. ~~Piminodine has~~ similar ~~effects~~ to other opioids, ~~and produces analgesia~~, ~~sedation~~ and ~~euphoria~~. ~~Side effects can include itching, nausea and respiratory depression~~.		{{Short description\|An opioid analgesic drug}}
			{{Drugbox
			\| verifiedfields = changed
			\| verifiedrevid = 477002123
			\| image = Piminodine.svg
			\| image_size = 200px
			\| image_alt = Structural formula of Piminodine
			}}

			'''Piminodine''' is a synthetic opioid analgesic that was developed in the mid-20th century. It is chemically related to [[methadone]] and is part of the [[piperidine]] class of opioids. Piminodine was primarily used for its analgesic properties, but its use has been limited due to the potential for abuse and addiction.

			==Chemical structure and properties==
			Piminodine is a member of the piperidine class of compounds, which are characterized by a six-membered ring containing five carbon atoms and one nitrogen atom. The chemical structure of piminodine is similar to that of other opioids, with modifications that affect its pharmacological properties.

			[[File:Piminodine.svg\|thumb\|right\|200px\|Structural formula of Piminodine]]

			The molecular formula of piminodine is C<sub>20</sub>H<sub>29</sub>NO, and it has a molecular weight of 299.45 g/mol. The presence of the piperidine ring is a key feature that contributes to its activity as an opioid receptor agonist.

	==Pharmacology==		==Pharmacology==
	Piminodine ~~is a~~ [[mu-opioid receptor]] ~~agonist~~. ~~It is around~~ as ~~potent~~ as ~~meperidine as an analgesic, but has~~ a ~~longer duration~~ of ~~action. Piminodine is metabolized in the liver~~, ~~and~~ its ~~metabolites are excreted by the kidneys~~.		Piminodine acts primarily as an agonist at the [[mu-opioid receptor]], which is responsible for its analgesic effects. Activation of these receptors leads to a decrease in the perception of pain, as well as a sense of euphoria, which can contribute to its potential for abuse.

	~~==Chemistry==~~		The drug's pharmacokinetics, including its absorption, distribution, metabolism, and excretion, are similar to those of other opioids. Piminodine is metabolized in the liver and excreted primarily through the kidneys.
	~~Piminodine is a 4-phenylpiperidine derivative that is structurally related~~ to ~~the opioid analgesic drug pethidine~~. ~~The only difference~~ is ~~that~~ the ~~N-methyl group of pethidine is replaced by an N-phenethyl group, which is~~ the ~~structural feature that turns it into a potent opioid agonist~~.

	==~~History~~==		==Medical use==
	Piminodine was ~~first synthesized by Hoffmann-La Roche~~ in the ~~1950s, along with a variety~~ of ~~other analogs of pethidine~~, ~~in an attempt to find synthetic opioids with improved pharmacological properties compared~~ to the ~~natural opium alkaloids which were the mainstay~~ of ~~analgesic therapy at the time~~.		Piminodine was used in the past for the management of moderate to severe pain. However, due to its potential for addiction and the development of safer alternatives, its use in clinical practice has declined.

	==~~Legal Status~~==		==Side effects==
	~~Piminodine is a Schedule II drug under the Convention on Psychotropic Substances. In the United States~~, ~~it is~~ a ~~Schedule II controlled substance. The DEA number is 9737~~.		As with other opioids, piminodine can cause a range of side effects. Common side effects include:
			* [[Nausea]]
			* [[Vomiting]]
			* [[Constipation]]
			* [[Drowsiness]]
			* [[Dizziness]]

	==~~See Also~~==		Serious side effects may include respiratory depression, which can be life-threatening, especially in cases of overdose.

			==Legal status==
			Piminodine is classified as a controlled substance in many countries due to its potential for abuse and addiction. Its use is strictly regulated, and it is not commonly prescribed in modern medical practice.

			==Related pages==
	* [[Opioid]]		* [[Opioid]]
	* [[Analgesic]]		* [[Analgesic]]
	* [[~~Pethidine~~]]		* [[Methadone]]
	* [[~~Hoffmann-La Roche~~]]		* [[Piperidine]]

	[[Category:Opioids]]		[[Category:Opioids]]
	[[Category:Analgesics]]		[[Category:Analgesics]]
	[[Category:~~Phenethylpiperidines~~]]		[[Category:Piperidines]]
	~~[[Category:Mu-opioid agonists]]~~

	~~{{stub}}~~

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2024-02-25T22:11:30Z

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'''Piminodine''' is an [[opioid]] [[analgesic]] that is an analog of [[pethidine]] (meperidine). It was developed by [[Hoffmann-La Roche]] in the 1950s. Piminodine has similar effects to other opioids, and produces analgesia, sedation and euphoria. Side effects can include itching, nausea and respiratory depression.

==Pharmacology==
Piminodine is a [[mu-opioid receptor]] agonist. It is around as potent as meperidine as an analgesic, but has a longer duration of action. Piminodine is metabolized in the liver, and its metabolites are excreted by the kidneys.

==Chemistry==
Piminodine is a 4-phenylpiperidine derivative that is structurally related to the opioid analgesic drug pethidine. The only difference is that the N-methyl group of pethidine is replaced by an N-phenethyl group, which is the structural feature that turns it into a potent opioid agonist.

==History==
Piminodine was first synthesized by Hoffmann-La Roche in the 1950s, along with a variety of other analogs of pethidine, in an attempt to find synthetic opioids with improved pharmacological properties compared to the natural opium alkaloids which were the mainstay of analgesic therapy at the time.

==Legal Status==
Piminodine is a Schedule II drug under the Convention on Psychotropic Substances. In the United States, it is a Schedule II controlled substance. The DEA number is 9737.

==See Also==
* [[Opioid]]
* [[Analgesic]]
* [[Pethidine]]
* [[Hoffmann-La Roche]]

[[Category:Opioids]]
[[Category:Analgesics]]
[[Category:Phenethylpiperidines]]
[[Category:Mu-opioid agonists]]

{{stub}}

Piminodine - Revision history

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