https://wikimd.com/index.php?action=history&feed=atom&title=Phenylephrine 2026-04-21T06:53:08Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Phenylephrine&diff=2537682&oldid=prev 2021-09-13T21:21:44Z

<p></p> <p><b>New page</b></p><div>It is a powerful [[vasoconstrictor]] which is commonly used to dilate the [[pupils]] and relieve [[nasal congestion]]. Available as injection under the brand name, VAZCULEP (phenylephrine hydrochloride), it is an intravenous medication first approved by the US [[FDA]] in 1954.<br /> [[File:Phenylephrine.png|alt=Chemical structure of Phenylephrine|thumb|Chemical structure of Phenylephrine]]<br /> <br /> ==What are the uses of Phenylephrine?==<br /> Phenylephrine hydrochloride) Injection is an alpha-1 adrenergic receptor agonist indicated for the treatment of clinically important hypotension resulting primarily from vasodilation in the setting of anesthesia. <br /> <br /> ==What is the recommended dosage?==<br /> * VAZCULEP (phenylephrine hydrochloride) Injection, 10 mg/mL, is injected intravenously either as a bolus or in a dilute solution as a continuous infusion.<br /> * Dosing for treatment of hypotension during anesthesia  Bolus intravenous injection: 40 mcg to 100 mcg every 1-2 minutes as needed, not to exceed 200 mcg. <br /> * Intravenous infusion: 10 mcg/min to 35 mcg/min, titrating to effect, not to exceed 200 mcg/min. <br /> * The dose should be adjusted according to the pressor response (i.e., titrate to effect). <br /> [[File:Phenylephrine3D.png|alt=Phenylephrine 3D|thumb|Phenylephrine 3D]]<br /> <br /> ==How is this medication supplied?==<br /> # 1 mL single use vials containing 10 mg phenylephrine hydrochloride (10 mg/mL)<br /> # 5 mL pharmacy bulk package vials containing 50 mg phenylephrine hydrochloride (10 mg/mL)<br /> # 10 mL pharmacy bulk package vials containing 100 mg phenylephrine hydrochloride (10 mg/mL)<br /> <br /> ==What are the warnings and precautions I should be aware of?==<br /> * Extravasation during intravenous administration may cause necrosis or sloughing of tissue<br /> * Severe bradycardia and decreased cardiac output<br /> * Allergic-type reactions: Sulfite<br /> * Concomitant use with oxytocic drugs: Pressor effect of sympathomimetic pressor amines is potentiated<br /> <br /> ==What side effects can this medication cause?==<br /> Most common adverse reactions during treatment include [[nausea]], [[vomiting]], and [[headache]].<br /> <br /> ==What drug interactions can this medication cause?==<br /> * Agonistic effects with monoamine oxidase inhibitors (MAOI), oxytocin and oxytocic drugs, tricyclic antidepressants, angiotensin and aldosterone, atropine, steroids, norepinephrine transporter inhibitors, ergot alkaloids <br /> * Antagonistic effects with α-adrenergic antagonists, phosphodiesterase Type <br /> <br /> ==Can this medication be used in pregnancy?==<br /> No. Based on animal data, may cause fetal harm. <br /> {{coststubd}}<br /> <br /> {{Cardiac stimulants excluding cardiac glycosides}}<br /> {{Nasal preparations}}<br /> {{Mydriatics and cycloplegics}}<br /> {{Adrenergics}}<br /> {{Phenethylamines}}<br /> <br /> [[Category:Rhinology]]<br /> [[Category:Phenethylamines]]<br /> [[Category:Alpha-adrenergic agonists]]<br /> [[Category:Cardiac stimulants]]<br /> [[Category:Topical decongestants]]<br /> [[Category:Phenols]]<br /> [[Category:Secondary alcohols]]<br /> [[Category:Amines]]<br /> [[Category:Vasoconstrictors]]</div>

Prab