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2025-02-18T04:55:55Z

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	[[Category:Neurotransmitters]]		[[Category:Neurotransmitters]]
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			==Phenibut==
			<gallery>
			File:Phenibut_skeletal_formula.svg\|Skeletal formula of Phenibut
			File:Phenibut_ball-and-stick_model.png\|Ball-and-stick model of Phenibut
			File:Phenibut_and_analogues.png\|Phenibut and its analogues
			File:Phenibut_from_Russia.png\|Phenibut from Russia
			</gallery>

Prab at 02:04, 25 May 2023

2023-05-25T02:04:27Z

New page

[[Phenibut]], known by the brand names Anvifen, Fenibut, and Noofen, among others, is a pharmaceutical agent with anxiolytic (anxiety-reducing) properties. It functions as a central nervous system depressant and is used to manage a spectrum of conditions including anxiety, insomnia, and certain other neuropsychiatric disorders.<ref>{{Cite journal |title=Phenibut Addiction in a Patient with Substance Use Disorder |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5662439/ |journal=Cureus |date=2017 |access-date=2023-05-18}}</ref>

==Pharmacology and Mechanism of Action==

Phenibut primarily exerts its effects by modulating the [[GABA receptor]], particularly the GABA-B subtype. GABA, or gamma-aminobutyric acid, is the primary inhibitory neurotransmitter in the human nervous system, and substances that enhance GABA's activity tend to produce calming, sedative effects.<ref>{{Cite journal |title=Phenibut (β-Phenyl-GABA): A Tranquilizer and Nootropic Drug |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3604470/ |journal=CNS Drug Reviews |date=2012 |access-date=2023-05-18}}</ref>

==Therapeutic Uses==

Phenibut is primarily used to treat anxiety and insomnia, but it also has utility in the management of alcohol withdrawal syndrome, vestibular disorders, and other conditions. It is typically administered orally in a tablet form, although it can be given intravenously under certain circumstances.<ref>{{Cite journal |title=Phenibut withdrawal management in the setting of concomitant kratom and alcohol dependence |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6343615/ |journal=Critical Care |date=2018 |access-date=2023-05-18}}</ref>

==Side Effects and Cautions==

Like all medications, Phenibut has potential side effects, including sedation, nausea, irritability, and, in some cases, withdrawal symptoms upon abrupt discontinuation. It should be used with caution, particularly in individuals with a history of substance use disorders, as it has the potential for misuse and dependence.<ref>{{Cite journal |title=Phenibut: A Tranquilizer and Nootropic Drug with Abuse Potential |url=https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6494145/ |journal=Journal of Addiction Medicine |date=2019 |access-date=2023-05-18}}</ref>

==See Also==
* [[GABA receptor]]
* [[Anxiolytic]]
* [[Neurotransmitter]]
==References==
<references />
{{stub}}
[[Category:Psychopharmacology]]
[[Category:Neurotransmitters]]
[[Category:Psychoactive drugs]]

Phenibut - Revision history

Prab: CSV import

Prab at 02:04, 25 May 2023