Prab: CSV import

2025-03-17T22:57:12Z

CSV import

← Older revision		Revision as of 22:57, 17 March 2025
Line 52:		Line 52:
	{{medicine-stub}}		{{medicine-stub}}
	{{No image}}		{{No image}}
			__NOINDEX__

Prab: CSV import

2025-02-11T04:54:08Z

CSV import

← Older revision		Revision as of 04:54, 11 February 2025
Line 51:		Line 51:

	{{medicine-stub}}		{{medicine-stub}}
			{{No image}}

Prab: CSV import

2024-08-13T15:12:46Z

CSV import

New page

{{Infobox protein
| Name = Perlecan
| caption =
| image =
| width =
| HGNCid = 8851
| Symbol = HSPG2
| AltSymbols =
| EntrezGene = 3339
| OMIM = 142461
| RefSeq = NM_005529
| UniProt = P98160
| PDB =
| ECnumber =
| Chromosome = 1
| Arm = p
| Band = 36.12
| LocusSupplementaryData =
}}

'''Perlecan''' is a large [[heparan sulfate]] [[proteoglycan]] that is a major component of the [[basement membrane]], a specialized form of [[extracellular matrix]]. Perlecan plays a critical role in the structural integrity and bioactivity of the basement membrane by interacting with other matrix components and cellular receptors. It is encoded by the ''HSPG2'' gene located on chromosome 1p36.12.

==Structure==
Perlecan has a core protein of approximately 470 kDa and can have up to five [[glycosaminoglycan]] (GAG) chains attached, which are predominantly heparan sulfate. The core protein consists of five domains, each with specific binding functions for other matrix components and growth factors. This modular structure allows perlecan to interact with a variety of cell surface receptors, including [[integrins]] and [[growth factor]] receptors, which mediate cellular responses to the extracellular environment.

==Function==
Perlecan is involved in multiple biological processes including:
* [[Cell adhesion]]
* [[Cell proliferation]]
* [[Tissue repair]]
* [[Angiogenesis]]
* [[Blood coagulation]]

It serves not only as a structural scaffold but also as a reservoir for growth factors within the basement membrane, regulating their availability and activity. Perlecan's ability to bind to various growth factors such as [[fibroblast growth factor]] (FGF) and [[vascular endothelial growth factor]] (VEGF) facilitates their protective roles in vascular and tissue homeostasis.

==Clinical Significance==
Mutations in the ''HSPG2'' gene that encodes perlecan can lead to several genetic disorders, including [[Schwartz-Jampel syndrome]] and [[Dyggve-Melchior-Clausen syndrome]]. These conditions are characterized by skeletal abnormalities, among other symptoms, underscoring the importance of perlecan in skeletal development and maintenance.

In addition to genetic disorders, alterations in perlecan expression and function have been implicated in various pathological conditions such as:
* [[Cancer]]
* [[Atherosclerosis]]
* [[Diabetes mellitus]]
* [[Neurodegenerative diseases]]

==Research==
Ongoing research is exploring the therapeutic potential of perlecan in promoting tissue regeneration and repair, as well as its role in the progression of various diseases. Understanding the multifunctional roles of perlecan could lead to novel therapeutic strategies for diseases associated with basement membrane dysfunction.

[[Category:Proteoglycans]]
[[Category:Extracellular matrix proteins]]
[[Category:Genes on human chromosome 1]]

{{medicine-stub}}

Perlecan - Revision history

Prab: CSV import

Prab: CSV import

Prab: CSV import