https://wikimd.com/index.php?action=history&feed=atom&title=Pergolide 2026-04-22T22:24:28Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=Pergolide&diff=4968494&oldid=prev 2023-09-17T19:12:13Z

<p></p> <p><b>New page</b></p><div>{{intro}}<br /> [[File:Pergolid Structural Formulae V.1.svg|Pergolid Structural Formulae|thumb]]<br /> Pergolide is an oral dopamine receptor agonist used predominantly in the therapy of [[Parkinson disease]].<br /> {{livtox}}<br /> Pergolide therapy is associated with low rate of transient serum enzyme elevations during treatment and has been implicated in rare cases of acute liver injury.<br /> {{moa}}<br /> Pergolide (per&#039; goe lide) is an ergot derivative similar to bromocriptine which acts as a dopamine receptor agonist.  Pergolide, unlike bromocriptine, has agonist activity on both D1 and D2 dopamine receptors and acts directly on the substantia nigra.  <br /> {{fda}}<br /> Pergolide was approved for use in the United States in 1988 and has been in use since in the therapy of symptomatic [[Parkinson disease]], usually in combination with levodopa/carbidopa.  <br /> {{dose}}<br /> Pergolide is available in tablets of 0.05, 0.25 and 1.0 mg in generic forms and under the brand name of Permax.  The typical initiating dose of pergolide is 0.05 mg once daily for the first 2 days, with gradual increase thereafter based upon tolerance and effect.  The average therapeutic dose in clinical studies was 3 mg per day given in 3 divided doses. <br /> {{se}}<br /> Common side effects include profound hypotension (with the first dose), somnolence, fatigue, vivid dreams, insomnia, anxiety, [[confusion]], depression, dizziness, headache, [[nausea]] and gastrointestinal upset. <br /> {{Navboxes<br /> | title = [[Medical use]]s<br /> | titlestyle = background:#ccccff<br /> | list1 = <br /> {{Antiparkinson}}<br /> {{Prolactin inhibitors and anti-inflammatory products for vaginal administration}}<br /> {{Hallucinogens}}<br /> }}<br /> {{Navboxes<br /> | title = [[Pharmacodynamics]]<br /> | titlestyle = background:#ccccff<br /> | list1 = <br /> {{Adrenergic receptor modulators}}<br /> {{Dopamine receptor modulators}}<br /> {{Prolactin receptor modulators}}<br /> {{Serotonin receptor modulators}}<br /> }}<br /> {{Ergolines}}<br /> {{stubd}}<br /> [[Category:5-HT2B agonists]]<br /> [[Category:D2-receptor agonists]]<br /> [[Category:D3 receptor agonists]]<br /> [[Category:D4 receptor agonists]]<br /> [[Category:Dopamine receptor modulators]]<br /> [[Category:Equine medications]]<br /> [[Category:Ergolines]]<br /> [[Category:Prolactin inhibitors]]<br /> [[Category:Thioethers]]<br /> [[Category:Withdrawn drugs]]</div>

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