https://wikimd.org/index.php?action=history&feed=atom&title=PentostatinPentostatin - Revision history2026-04-26T22:34:38ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Pentostatin&diff=6310434&oldid=prevPrab: CSV import2025-02-18T01:07:39Z<p>CSV import</p>
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</table>Prabhttps://wikimd.org/index.php?title=Pentostatin&diff=687707&oldid=prevPrab: 1 revision imported2019-09-01T19:37:58Z<p>1 revision imported</p>
<p><b>New page</b></p><div>{{intro}}<br />
Pentostatin is a purine analogue and antineoplastic agent used in the therapy of hairy cell [[leukemia]] and T cell [[lymphoma]]s.<br />
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{{livtox}}<br />
Pentostatin is associated with a low rate of serum enzyme elevations during therapy and has been linked to rare instances of severe acute [[liver injury]] with jaundice. <br />
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{{moa}}<br />
Pentostatin (pen" toe stat' in) is a purine analogue (2'-deoxycoformycin) that is used in the [[treatment]] of hairy cell [[leukemia]] and T cell [[lymphoma]]s. Pentostatin is a transition state analogue of a major intermediate in the pathway of the adenosine deaminase reaction. As a consequence, pentostatin inhibits adenosine deaminase and causes accumulation of intracellular adenosine and deoxyadenosine which cause a block [[DNA]] synthesis. This imbalance of nucleotide pools is particularly toxic to lymphocytes. <br />
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{{fda}}<br />
Pentostatin was found to have marked activity against hairy [[leukemia]] and T cell [[lymphoma]]s and was approved for this use in the United States in 1991. <br />
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{{dose}} <br />
Pentostatin is available as a solution for injection generically and under the trade name Nipent. The typical dose regimen is 4 mg/m2 given intravenously every other week for 6 months. Repeat courses are recommended only for patients who have a response and later relapse. <br />
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{{se}}<br />
Common [[side effects]] include [[bone marrow suppression]], [[fever]], infections, [[nausea]], [[vomiting]], [[anorexia]], [[diarrhea]], [[headache]], [[fatigue]] and [[skin rash]]. Because pentostatin tends to deplete normal T cells, opportunistic infections can occur and immunosuppression can persist for months or years after discontinuation. At high doses, pentostatin can cause severe renal and neurologic toxicity and in combination with fludarabine can cause pulmonary toxicity. <br />
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{{cancer drugs}} <br />
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