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			== Penicillin-binding proteins ==
			<gallery>
			File:3OC2_Wiki.png\|Structure of a penicillin-binding protein
			File:Penicillin_inhibition.svg\|Mechanism of penicillin inhibition
			File:Penicillin_Binding_Protein_3_and_Carbenicillin_Interaction.png\|Interaction of penicillin-binding protein 3 with carbenicillin
			File:Penicillin_Core.svg\|Core structure of penicillin
			File:Filamentation_1.jpg\|Penicillin-binding proteins
			</gallery>

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'''Penicillin-binding proteins''' ('''PBPs''') are a group of proteins that are characterized by their affinity to and binding of [[penicillin]]. They are a crucial component of the bacterial cell wall synthesis.

== Function ==

PBPs are involved in the final stages of constructing the bacterial cell wall, which is essential for the bacteria's survival. They catalyze a number of processes including the cross-linking of the peptidoglycan polymers that give the cell wall its strength.

== Interaction with Penicillin ==

[[Penicillin]] and other [[beta-lactam antibiotics]] inhibit PBPs, which disrupts cell wall synthesis and leads to cell death. This is the primary mode of action of these antibiotics.

== Types of PBPs ==

There are several types of PBPs, each with a specific role in cell wall synthesis. These include:

* High molecular weight PBPs: These are involved in the cross-linking of the peptidoglycan polymers.
* Low molecular weight PBPs: These are involved in other aspects of cell wall synthesis, such as the modification of the peptidoglycan polymers.

== Resistance to Penicillin ==

Some bacteria have developed resistance to penicillin and other beta-lactam antibiotics. This is often due to the production of [[beta-lactamase]] enzymes, which break down the antibiotic and render it ineffective. However, some bacteria have also developed altered PBPs that have a lower affinity for penicillin, reducing the antibiotic's effectiveness.

== See Also ==

* [[Beta-lactam antibiotics]]
* [[Beta-lactamase]]
* [[Cell wall]]
* [[Peptidoglycan]]

[[Category:Proteins]]
[[Category:Antibiotics]]
[[Category:Bacterial cell structure]]

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Penicillin-binding proteins - Revision history

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