https://wikimd.org/index.php?action=history&feed=atom&title=Pain_wind-up 2026-04-26T22:02:03Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Pain_wind-up&diff=6517414&oldid=prev 2025-03-17T22:48:45Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 22:48, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l24">Line 24:</td> <td colspan="2" class="diff-lineno">Line 24:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Chronic pain]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Chronic pain]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=Pain_wind-up&diff=6258006&oldid=prev 2025-02-10T20:46:40Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:46, 10 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l23">Line 23:</td> <td colspan="2" class="diff-lineno">Line 23:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pain]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Pain]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Chronic pain]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:Chronic pain]]</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=Pain_wind-up&diff=5207679&oldid=prev 2024-02-22T04:47:01Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Pain wind-up&#039;&#039;&#039; is a phenomenon that occurs in the [[nervous system]] where the body&#039;s response to pain becomes progressively greater with each stimulus. This is due to the increased excitability of [[neurons]] in the [[spinal cord]] to the input from the [[peripheral nerves]]. <br /> <br /> ==Mechanism==<br /> The mechanism of pain wind-up involves the activation of [[NMDA receptors]] on neurons in the spinal cord. These receptors are normally blocked by [[magnesium ions]], but when a strong or repeated pain stimulus is applied, the magnesium block is removed and the NMDA receptors become activated. This leads to an influx of [[calcium ions]] into the neuron, which triggers a series of events that result in the neuron becoming more responsive to future pain stimuli.<br /> <br /> ==Clinical significance==<br /> Pain wind-up is thought to play a role in the development of [[chronic pain]] conditions. It is believed that the increased excitability of neurons in the spinal cord can lead to a state of [[hyperalgesia]], where a person experiences an increased sensitivity to pain. This can make it difficult to manage pain in conditions such as [[fibromyalgia]], [[neuropathic pain]], and [[migraine]].<br /> <br /> ==Treatment==<br /> Treatment strategies for pain wind-up focus on preventing the activation of NMDA receptors. This can be achieved through the use of medications such as [[ketamine]] and [[dextromethorphan]], which are known to block NMDA receptors. Other treatments may involve [[physical therapy]] or [[cognitive behavioral therapy]] to help manage the psychological aspects of chronic pain.<br /> <br /> ==See also==<br /> * [[Nociception]]<br /> * [[Pain management]]<br /> * [[Central sensitization]]<br /> <br /> ==References==<br /> &lt;references/&gt;<br /> <br /> {{stub}}<br /> <br /> [[Category:Neurology]]<br /> [[Category:Pain]]<br /> [[Category:Chronic pain]]</div>

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