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Pacinian corpuscle - Revision history
2026-04-21T07:17:39Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 04:56, 18 February 2025</td>
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2024-02-23T22:34:48Z
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<p><b>New page</b></p><div>'''Pacinian corpuscles''' (or '''Lamellar corpuscles''') are one of the four major types of [[mechanoreceptor]]. They are nerve endings in the skin responsible for sensitivity to vibration and pressure. Vibrational role specifically helps detect surface texture, e.g., rough vs. smooth. Pacinian corpuscles are the most obvious as they form large structures (up to 1 mm long), easiest to see in routine histology.<br />
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== Structure ==<br />
Pacinian corpuscles are oval-shaped and approximately 1 mm in length. The corpuscle is layered like an onion; each layer is a thin, flat [[Schwann cell]]. Inside the corpuscle, there is a non-myelinated terminal [[axon]].<br />
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== Function ==<br />
Pacinian corpuscles detect gross pressure changes and vibrations. Any deformation in the corpuscle causes action potentials to be generated, by deforming the [[Neuron|neuronal membrane]] and causing [[Sodium channel|sodium ion channels]] to open up.<br />
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== Clinical significance ==<br />
Pacinian corpuscles cause action potentials when the skin is rapidly indented but not when the pressure is steady, due to the layers of connective tissue that cover the nerve ending. It is thought that they respond to high velocity changes in joint position.<br />
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== See also ==<br />
* [[Meissner's corpuscle]]<br />
* [[Merkel cell]]<br />
* [[Ruffini ending]]<br />
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== References ==<br />
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[[Category:Human anatomy]]<br />
[[Category:Sensory systems]]<br />
[[Category:Nervous system]]<br />
{{anatomy-stub}}</div>
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