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	~~'''PLGA''' (~~Poly(lactic-co-glycolic acid)) is a copolymer which is used in a host of [[Food and Drug Administration\|FDA]]-approved therapeutic devices, owing to its biodegradability and biocompatibility. PLGA is naturally amorphous (not crystalline).		{{DISPLAYTITLE:Poly(lactic-co-glycolic acid)}}

	== ~~History~~ ==		==Poly(lactic-co-glycolic acid)==
	PLGA ~~was first developed~~ in the ~~early 1970s~~ and ~~has since been used in a variety~~ of ~~medical applications~~.		[[File:PLGA.svg\|thumb\|right\|Chemical structure of PLGA]]
			'''Poly(lactic-co-glycolic acid)''' ('''PLGA''') is a biodegradable and biocompatible copolymer that is widely used in [[biomedical]] applications, particularly in the field of [[drug delivery]] and [[tissue engineering]]. PLGA is synthesized by the random copolymerization of two different monomers, [[lactic acid]] and [[glycolic acid]].

	== ~~Composition~~ ==		==Chemical Properties==
	PLGA is ~~a copolymer made from two different monomers~~, [[~~Lactic acid\|~~lactic acid]] and [[~~Glycolic acid\|~~glycolic acid]], ~~for biomedical applications~~.		PLGA is an [[aliphatic polyester]] that is known for its ability to degrade into non-toxic byproducts, specifically [[lactic acid]] and [[glycolic acid]], which are naturally metabolized by the body. The degradation rate of PLGA can be controlled by adjusting the ratio of lactic acid to glycolic acid in the copolymer. Typically, PLGA with a higher glycolic acid content degrades faster than those with a higher lactic acid content.

	== ~~Properties~~ ==		==Synthesis==
	PLGA is ~~unique in that it is biodegradable and biocompatible, making it~~ a ~~safe choice for many medical applications. The degradation rate~~ of ~~PLGA is adjustable based on~~ the ~~ratio~~ of lactic acid to glycolic acid.		PLGA is synthesized through a process called [[ring-opening polymerization]] of the cyclic dimers of lactic acid and glycolic acid, known as [[lactide]] and [[glycolide]], respectively. The polymerization process is typically catalyzed by [[stannous octoate]] or other catalysts, and the resulting polymer can be tailored to have different molecular weights and copolymer ratios.

	== Applications ==		==Applications==
	PLGA is used in ~~a variety~~ of ~~medical applications, including:~~		PLGA is extensively used in the development of [[controlled drug delivery systems]]. Its ability to encapsulate a wide range of therapeutic agents, including [[proteins]], [[peptides]], and [[small molecules]], makes it a versatile material for drug delivery. PLGA-based systems can provide sustained release of drugs over extended periods, improving patient compliance and therapeutic outcomes.
	* [[~~Drug~~ delivery systems~~\|Drug delivery~~]]
	* [[~~Surgical sutures\|Sutures~~]]
	* [[~~Orthopedic devices\|Orthopedic devices~~]]
	* [[~~Tissue engineering\|Tissue engineering~~]]

	~~== See also ==~~		In [[tissue engineering]], PLGA is used to fabricate [[scaffolds]] that support cell growth and tissue regeneration. Its biocompatibility and tunable degradation rates make it an ideal material for creating scaffolds that can gradually degrade as new tissue forms.
	* [[~~Biodegradable polymer\|Biodegradable polymer~~]]
	* [[~~Biocompatible material\|Biocompatible material]]~~
	* [[Drug delivery\|Drug delivery]]
	* [[Surgical suture\|Surgical suture]]
	* [[Orthopedic devices\|Orthopedic devices]]
	* [[Tissue engineering\|Tissue engineering]]

	== ~~References~~ ==		==Advantages==
	~~<references />~~		PLGA offers several advantages in biomedical applications:
			* '''Biodegradability''': PLGA degrades into lactic acid and glycolic acid, which are naturally metabolized by the body.
			* '''Biocompatibility''': It is well-tolerated by the body and does not elicit significant immune responses.
			* '''Versatility''': The copolymer ratio can be adjusted to control the degradation rate and mechanical properties.

	[[~~Category:~~Biodegradable ~~materials~~]]		==Challenges==
	[[Category:~~Biocompatible materials~~]]		Despite its advantages, PLGA also presents some challenges:
			* '''Acidic Degradation Products''': The degradation of PLGA can lead to the accumulation of acidic byproducts, which may affect the stability of encapsulated drugs or the surrounding tissue.
			* '''Hydrophobicity''': PLGA is relatively hydrophobic, which can limit its ability to encapsulate hydrophilic drugs without modification.

			==Related pages==
			* [[Biodegradable polymer]]
			* [[Drug delivery]]
			* [[Tissue engineering]]
			* [[Lactic acid]]
			* [[Glycolic acid]]

			[[Category:Biodegradable polymers]]
	[[Category:Drug delivery devices]]		[[Category:Drug delivery devices]]
	~~[[Category:Surgical sutures]]~~
	~~[[Category:Orthopedic devices]]~~
	[[Category:Tissue engineering]]		[[Category:Tissue engineering]]

	~~{{stub}}~~

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'''PLGA''' (Poly(lactic-co-glycolic acid)) is a copolymer which is used in a host of [[Food and Drug Administration|FDA]]-approved therapeutic devices, owing to its biodegradability and biocompatibility. PLGA is naturally amorphous (not crystalline).

== History ==
PLGA was first developed in the early 1970s and has since been used in a variety of medical applications.

== Composition ==
PLGA is a copolymer made from two different monomers, [[Lactic acid|lactic acid]] and [[Glycolic acid|glycolic acid]], for biomedical applications.

== Properties ==
PLGA is unique in that it is biodegradable and biocompatible, making it a safe choice for many medical applications. The degradation rate of PLGA is adjustable based on the ratio of lactic acid to glycolic acid.

== Applications ==
PLGA is used in a variety of medical applications, including:
* [[Drug delivery systems|Drug delivery]]
* [[Surgical sutures|Sutures]]
* [[Orthopedic devices|Orthopedic devices]]
* [[Tissue engineering|Tissue engineering]]

== See also ==
* [[Biodegradable polymer|Biodegradable polymer]]
* [[Biocompatible material|Biocompatible material]]
* [[Drug delivery|Drug delivery]]
* [[Surgical suture|Surgical suture]]
* [[Orthopedic devices|Orthopedic devices]]
* [[Tissue engineering|Tissue engineering]]

== References ==
<references />

[[Category:Biodegradable materials]]
[[Category:Biocompatible materials]]
[[Category:Drug delivery devices]]
[[Category:Surgical sutures]]
[[Category:Orthopedic devices]]
[[Category:Tissue engineering]]

{{stub}}

PLGA - Revision history

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