https://wikimd.com/index.php?action=history&feed=atom&title=PIAS3 2026-04-05T18:59:44Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.com/index.php?title=PIAS3&diff=6516108&oldid=prev 2025-03-17T21:24:40Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:24, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l28">Line 28:</td> <td colspan="2" class="diff-lineno">Line 28:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr> </table>

Prab https://wikimd.com/index.php?title=PIAS3&diff=6277206&oldid=prev 2025-02-11T04:48:47Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 04:48, 11 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l27">Line 27:</td> <td colspan="2" class="diff-lineno">Line 27:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:EC 2.3.2]]</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>[[Category:EC 2.3.2]]</div></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table>

Prab https://wikimd.com/index.php?title=PIAS3&diff=5300424&oldid=prev 2024-02-25T22:29:49Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;PIAS3&#039;&#039;&#039; is a protein that in humans is encoded by the PIAS3 gene. It has been identified as a specific inhibitor of STAT3 and is involved in various biological processes.<br /> <br /> == Function ==<br /> [[PIAS3]] is a member of the [[protein inhibitor of activated STAT]] (PIAS) family. These proteins function as [[SUMO E3 ligases]] and regulate the activity of various transcription factors. PIAS3 specifically inhibits [[STAT3]] transcriptional activity by blocking its DNA binding activity. This protein is found in the cytoplasm and can form a complex with UBE2I/UBC9. It also modulates STAT3 activation in response to a number of different stimuli, including [[Interleukin-6]] and [[Epidermal Growth Factor]].<br /> <br /> == Clinical significance ==<br /> Alterations in the PIAS3 gene have been associated with various diseases. For example, decreased expression of PIAS3 has been observed in [[glioblastoma]] cells, suggesting a potential role in the pathogenesis of this type of brain tumor. Additionally, PIAS3 has been implicated in the regulation of [[insulin]] signaling and glucose homeostasis, and alterations in this gene may contribute to the development of [[type 2 diabetes]].<br /> <br /> == See also ==<br /> * [[Protein inhibitor of activated STAT]]<br /> * [[STAT3]]<br /> * [[SUMO E3 ligases]]<br /> * [[Interleukin-6]]<br /> * [[Epidermal Growth Factor]]<br /> * [[Glioblastoma]]<br /> * [[Insulin]]<br /> * [[Type 2 diabetes]]<br /> <br /> == References ==<br /> &lt;references /&gt;<br /> <br /> == External links ==<br /> * [https://www.ncbi.nlm.nih.gov/gene/10401 PIAS3] at the [[National Center for Biotechnology Information]]<br /> <br /> [[Category:Human proteins]]<br /> [[Category:Transcription factors]]<br /> [[Category:EC 2.3.2]]<br /> {{stub}}</div>

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