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	<title>PAX4 - Revision history</title>
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	<updated>2026-04-24T07:53:04Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.com/index.php?title=PAX4&amp;diff=6516532&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=PAX4&amp;diff=6516532&amp;oldid=prev"/>
		<updated>2025-03-17T21:52:14Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 21:52, 17 March 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l33&quot;&gt;Line 33:&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=PAX4&amp;diff=6276827&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=PAX4&amp;diff=6276827&amp;oldid=prev"/>
		<updated>2025-02-11T04:43:04Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 04:43, 11 February 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l32&quot;&gt;Line 32:&lt;/td&gt;
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		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=PAX4&amp;diff=5331414&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=PAX4&amp;diff=5331414&amp;oldid=prev"/>
		<updated>2024-02-29T05:03:01Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;PAX4&amp;#039;&amp;#039;&amp;#039; is a gene that belongs to the paired box (PAX) family of transcription factors. This gene is involved in the regulation of organ development and tissue differentiation. PAX4 plays a crucial role in the development of the pancreas and the differentiation of insulin-producing beta cells.&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
&lt;br /&gt;
[[PAX4]] is a transcription factor that plays a key role in the development of the pancreas and the differentiation of insulin-producing beta cells. It is expressed in the early stages of pancreatic development and continues to be expressed in mature beta cells. Mutations in the PAX4 gene have been associated with [[diabetes mellitus type 2]] and [[Maturity onset diabetes of the young]] (MODY).&lt;br /&gt;
&lt;br /&gt;
== Structure ==&lt;br /&gt;
&lt;br /&gt;
The PAX4 gene is located on the long (q) arm of [[chromosome 7]] at position 32. The gene spans approximately 8.3 kilobases and consists of 9 exons. The encoded protein is 350 amino acids in length.&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
&lt;br /&gt;
Mutations in the PAX4 gene have been associated with an increased risk of developing type 2 diabetes. In addition, rare mutations in this gene have been identified in individuals with MODY, a form of diabetes that typically develops in adolescence or early adulthood.&lt;br /&gt;
&lt;br /&gt;
== Research ==&lt;br /&gt;
&lt;br /&gt;
Research on PAX4 has focused on its role in pancreatic development and its potential use in regenerative medicine. Studies have shown that overexpression of PAX4 can promote the differentiation of stem cells into insulin-producing beta cells, suggesting a potential therapeutic role for PAX4 in the treatment of diabetes.&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
* [[PAX genes]]&lt;br /&gt;
* [[Diabetes mellitus type 2]]&lt;br /&gt;
* [[Maturity onset diabetes of the young]]&lt;br /&gt;
* [[Transcription factor]]&lt;br /&gt;
* [[Beta cell]]&lt;br /&gt;
&lt;br /&gt;
== References ==&lt;br /&gt;
&amp;lt;references /&amp;gt;&lt;br /&gt;
&lt;br /&gt;
[[Category:Genes]]&lt;br /&gt;
[[Category:Transcription factors]]&lt;br /&gt;
[[Category:Diabetes]]&lt;br /&gt;
{{gene-stub}}&lt;br /&gt;
{{diabetes-stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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