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	~~'''~~PARGY-LAD''' (also known as '''1P-LSD''') is a psychedelic drug that is part of the [[lysergamide]] family. It is closely related to [[LSD]] and is reported to produce near-identical effects. PARGY-LAD was first synthesized by a team at Purdue University led by David Nichols. It is a derivative and functional analogue of LSD and a homologue of [[ALD-52]]. Given that it is a derivative of LSD, it is considered to be a semi-synthetic molecule of the lysergamide class.		== PARGY-LAD ==

	~~==Chemistry==~~		[[File:PARGY-LAD.svg\|thumb\|right\|Chemical structure of PARGY-LAD]]

	PARGY-LAD~~, or 1-propionyl-6-allyl-6-nor-lysergic acid diethylamide,~~ is a ~~semi-synthetic alkaloid of~~ the ~~lysergamide~~ class~~. The full name~~ of ~~the chemical is 1-propionyl-6-allyl-6-nor-~~lysergic acid ~~diethylamide~~. It is ~~similar in structure~~ to LSD~~, with an N,N-~~diethylamide ~~functional group bound to RN of the chemical structure. This core polycyclic structure~~ is ~~an indole derivative, and has tryptamine and phenethylamine groups embedded within it~~.		'''PARGY-LAD''' is a chemical compound that belongs to the class of [[lysergamides]], which are derivatives of [[lysergic acid]]. It is structurally related to other lysergamides such as [[LSD]] (lysergic acid diethylamide) and is known for its psychoactive properties.

	==~~Pharmacology~~==		=== Chemical Structure ===
			PARGY-LAD is characterized by its unique chemical structure, which includes a lysergic acid core with specific substitutions. The structure of PARGY-LAD can be visualized in the adjacent image, which shows the arrangement of atoms and functional groups that define this compound.

	~~Like LSD,~~ PARGY-LAD ~~likely~~ acts as a ~~5-HT2A partial~~ agonist~~. The psychedelic effects are believed to come from PARGY-LAD’s efficacy~~ at the 5-HT2A ~~receptors~~. ~~However~~, ~~the role of these interactions and how they result in the psychedelic experience continues~~ to ~~remain elusive~~.		=== Pharmacology ===
			PARGY-LAD acts primarily as a [[serotonin receptor]] agonist, particularly at the 5-HT2A receptor, which is believed to be responsible for its psychedelic effects. Like other lysergamides, it may also interact with other serotonin receptor subtypes, contributing to its complex pharmacological profile.

	==Effects==		=== Effects ===
			The effects of PARGY-LAD are similar to those of other psychedelic compounds, including alterations in perception, mood, and cognition. Users may experience visual and auditory hallucinations, changes in thought patterns, and an altered sense of time and space.

	The effects of PARGY-LAD are believed to include cognitive euphoria, distorted perception of colors, time, sounds and shapes, hallucinations, and spontaneous tactile sensations. The effects are reported to be somewhat similar to those of LSD, but with a less intense psychedelic headspace. Subjective effects of PARGY-LAD can include anxiety, visual hallucinations, time distortion, enhanced introspection, ego loss, and auditory hallucinations.		=== Legal Status ===
			The legal status of PARGY-LAD varies by country. In some jurisdictions, it may be classified as a controlled substance, while in others it may not be specifically regulated. It is important for individuals to be aware of the legal implications of possessing or using PARGY-LAD in their respective regions.
	==Legal Status==

	As of ~~2021,~~ PARGY-LAD is a controlled substance in ~~Latvia, Lithuania, and the United Kingdom~~. ~~Its legal status in other countries~~ is ~~unclear, but it could potentially~~ be ~~considered an analogue~~ of ~~LSD, and therefore illegal~~ in ~~countries with strong analogue laws, such as the United States~~.

	~~==See Also==~~

			== Related Pages ==
	* [[Lysergic acid diethylamide]]		* [[Lysergic acid diethylamide]]
	* [[Psychedelic drug]]		* [[Psychedelic drug]]
	* [[~~ALD-52~~]]		* [[Serotonin receptor]]

	~~[[Category:Psychoactive drugs]]~~
	[[Category:Lysergamides]]		[[Category:Lysergamides]]
	[[Category:~~Psychedelics~~]]		[[Category:Psychedelic drugs]]

	~~{{Psychoactive substance}}~~
	~~{{Pharmacology-stub}}~~
	~~{{Chemistry-stub}}~~

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2024-02-28T20:29:34Z

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'''PARGY-LAD''' (also known as '''1P-LSD''') is a psychedelic drug that is part of the [[lysergamide]] family. It is closely related to [[LSD]] and is reported to produce near-identical effects. PARGY-LAD was first synthesized by a team at Purdue University led by David Nichols. It is a derivative and functional analogue of LSD and a homologue of [[ALD-52]]. Given that it is a derivative of LSD, it is considered to be a semi-synthetic molecule of the lysergamide class.

==Chemistry==

PARGY-LAD, or 1-propionyl-6-allyl-6-nor-lysergic acid diethylamide, is a semi-synthetic alkaloid of the lysergamide class. The full name of the chemical is 1-propionyl-6-allyl-6-nor-lysergic acid diethylamide. It is similar in structure to LSD, with an N,N-diethylamide functional group bound to RN of the chemical structure. This core polycyclic structure is an indole derivative, and has tryptamine and phenethylamine groups embedded within it.

==Pharmacology==

Like LSD, PARGY-LAD likely acts as a 5-HT2A partial agonist. The psychedelic effects are believed to come from PARGY-LAD’s efficacy at the 5-HT2A receptors. However, the role of these interactions and how they result in the psychedelic experience continues to remain elusive.

==Effects==

The effects of PARGY-LAD are believed to include cognitive euphoria, distorted perception of colors, time, sounds and shapes, hallucinations, and spontaneous tactile sensations. The effects are reported to be somewhat similar to those of LSD, but with a less intense psychedelic headspace. Subjective effects of PARGY-LAD can include anxiety, visual hallucinations, time distortion, enhanced introspection, ego loss, and auditory hallucinations.

==Legal Status==

As of 2021, PARGY-LAD is a controlled substance in Latvia, Lithuania, and the United Kingdom. Its legal status in other countries is unclear, but it could potentially be considered an analogue of LSD, and therefore illegal in countries with strong analogue laws, such as the United States.

==See Also==

* [[Lysergic acid diethylamide]]
* [[Psychedelic drug]]
* [[ALD-52]]

[[Category:Psychoactive drugs]]
[[Category:Lysergamides]]
[[Category:Psychedelics]]

{{Psychoactive substance}}
{{Pharmacology-stub}}
{{Chemistry-stub}}

PARGY-LAD - Revision history

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