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	~~'''Oxilorphan''' is an [[~~opioid~~]] [[~~antagonist~~]] that was developed in the 1970s~~. ~~It is related to [[naloxone]] and is similar in effects, but has a longer duration~~ of ~~action.~~ Oxilorphan ~~is used in the treatment of [[drug addiction]] and has been researched for use in the treatment of [[pain]].~~		{{Short description\|Overview of the opioid antagonist Oxilorphan}}
			{{Drugbox
			\| verifiedrevid = 123456789
			\| image = Oxilorphan.svg
			\| image_size = 200px
			\| image_alt = Structural formula of Oxilorphan
			}}

	~~==Chemistry==~~		'''Oxilorphan''' is a [[opioid]] [[antagonist]] that has been studied for its effects on the [[central nervous system]]. It is a member of the [[morphinan]] class of compounds and has been investigated for its potential use in treating [[opioid addiction]] and [[pain management]].
	Oxilorphan is a ~~derivative~~ of [[morphinan]]~~, which is a type~~ of opioid. It is structurally ~~similar~~ to other ~~opioid antagonists~~ such as naloxone and [[naltrexone]]. ~~The~~ chemical ~~name for oxilorphan is 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6β-~~[~~(phenylthio)methyl~~]~~morphinan~~.
			==Chemical Structure==
			[[File:Oxilorphan.svg\|thumb\|right\|200px\|Chemical structure of Oxilorphan]]
			Oxilorphan is structurally related to other morphinan derivatives, such as [[naloxone]] and [[naltrexone]]. Its chemical structure allows it to bind to [[opioid receptors]] in the brain, where it acts primarily as an antagonist.

	==Pharmacology==		==Pharmacology==
	Oxilorphan acts ~~by binding to~~ the [[mu opioid receptor]]~~, where it has~~ antagonist effects. ~~This means~~ it ~~blocks~~ the effects of other opioids, ~~which can be~~ useful in ~~treating~~ opioid ~~addiction~~. It can also ~~be used to reverse~~ the ~~effects~~ of ~~opioids~~ in ~~cases~~ of ~~overdose~~.		Oxilorphan exhibits a unique pharmacological profile. It acts as a partial agonist at the [[mu-opioid receptor]] and as an antagonist at the [[kappa-opioid receptor]]. This dual action is responsible for its potential therapeutic effects and its ability to mitigate some of the side effects associated with opioid use.

			===Mechanism of Action===
			The primary mechanism of action of Oxilorphan involves its interaction with opioid receptors. By binding to these receptors, it can block the effects of other opioids, making it useful in the treatment of opioid dependence. Its partial agonist activity at the mu-opioid receptor can also provide some analgesic effects without the high risk of addiction.

			==Clinical Applications==
			Oxilorphan has been studied for several clinical applications, including:

			* '''Opioid Addiction Treatment''': As an opioid antagonist, Oxilorphan can help reduce cravings and withdrawal symptoms in individuals undergoing treatment for opioid addiction.
			* '''Pain Management''': Its partial agonist activity allows it to provide pain relief with a lower risk of addiction compared to full agonists like [[morphine]].

	==~~Clinical uses~~==		==Side Effects==
	Oxilorphan ~~has been used in the treatment of opioid addiction. It~~ can ~~help to reduce cravings and withdrawal symptoms in people who are dependent on opioids. It has also been researched for use in the treatment of pain~~, ~~although it is not commonly used for this purpose.~~		The use of Oxilorphan can be associated with several side effects, including:

	~~==Side effects==~~		* [[Nausea]]
	Like other opioid antagonists, oxilorphan can cause withdrawal symptoms in people who are dependent on opioids. These can include restlessness, irritability, and physical discomfort. Other side effects can include nausea, vomiting, and increased heart rate.		* [[Dizziness]]
			* [[Sedation]]
			* [[Respiratory depression]] (less common due to its antagonist properties)

	==~~See also~~==		==Research and Development==
	* [[Opioid ~~antagonist~~]]		Research into Oxilorphan has focused on its potential benefits and limitations in clinical settings. Studies have explored its efficacy in reducing opioid cravings and its safety profile compared to other opioid antagonists.

			==Related pages==
			* [[Opioid receptor]]
	* [[Naloxone]]		* [[Naloxone]]
	* [[Naltrexone]]		* [[Naltrexone]]
			* [[Opioid addiction]]

	[[Category:~~Opioids~~]]		[[Category:Opioid antagonists]]
	[[Category:~~Drugs~~]]		[[Category:Morphinans]]
	~~[[Category:Pharmacology]]~~

	~~{{stub}}~~

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'''Oxilorphan''' is an [[opioid]] [[antagonist]] that was developed in the 1970s. It is related to [[naloxone]] and is similar in effects, but has a longer duration of action. Oxilorphan is used in the treatment of [[drug addiction]] and has been researched for use in the treatment of [[pain]].

==Chemistry==
Oxilorphan is a derivative of [[morphinan]], which is a type of opioid. It is structurally similar to other opioid antagonists such as naloxone and [[naltrexone]]. The chemical name for oxilorphan is 17-cyclopropylmethyl-3,14-dihydroxy-4,5α-epoxy-6β-[(phenylthio)methyl]morphinan.

==Pharmacology==
Oxilorphan acts by binding to the [[mu opioid receptor]], where it has antagonist effects. This means it blocks the effects of other opioids, which can be useful in treating opioid addiction. It can also be used to reverse the effects of opioids in cases of overdose.

==Clinical uses==
Oxilorphan has been used in the treatment of opioid addiction. It can help to reduce cravings and withdrawal symptoms in people who are dependent on opioids. It has also been researched for use in the treatment of pain, although it is not commonly used for this purpose.

==Side effects==
Like other opioid antagonists, oxilorphan can cause withdrawal symptoms in people who are dependent on opioids. These can include restlessness, irritability, and physical discomfort. Other side effects can include nausea, vomiting, and increased heart rate.

==See also==
* [[Opioid antagonist]]
* [[Naloxone]]
* [[Naltrexone]]

[[Category:Opioids]]
[[Category:Drugs]]
[[Category:Pharmacology]]

{{stub}}

Oxilorphan - Revision history

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