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Deepika vegiraju: Created page with "== '''Alternate names''' == Axial osteosclerosis == '''Definition''' == Osteomesopyknosis is a bone disorder characterized by abnormal hardening of bone (osteosclerosis)...."

2021-02-11T13:02:20Z

Created page with "== '''Alternate names''' == Axial osteosclerosis == '''Definition''' == Osteomesopyknosis is a bone disorder characterized by abnormal hardening of bone (osteosclerosis)...."

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== '''Alternate names''' ==
Axial osteosclerosis

== '''Definition''' ==
Osteomesopyknosis is a bone disorder characterized by abnormal hardening of bone ([[osteosclerosis]]).

== '''Cause''' ==
The genetic cause has not yet been identified.

== '''Inheritance''' ==
[[File:Autosomal dominant - en.svg|thumb|right|Autosomal dominant pattern, a 50/50 chance.]]
* Osteomesopyknosis is inherited in an [[autosomal dominant]] manner.
* This means that having only one mutated copy of the responsible gene (which has not yet been identified) is enough to cause signs or symptoms of the disorder. When a person with an autosomal dominant condition has children, each child has a 50% (1 in 2) risk to be affected.
* There have been reported cases where both parents of an affected person did not appear to have the condition.
* The chance of having signs and symptoms when the responsible mutation is present (penetrance), and potential nature of signs and symptoms (expressivity), is not clear.

== '''Signs and symptoms''' ==
* Osteomesopyknosis may cause chronic, low-grade back pain in the [[thoracic]] (middle) and [[lumbar]] (lower) regions.
* It is considered a mild form of osteosclerosis and is usually found in young adults or teenagers.
* Height and intellect are not affected.
* Life expectancy in affected people is normal.
* There are cases of association with other findings such as ovarian [[sclerosis]] and [[lymphoma]]; however, it is uncertain whether they have been coincidental or features of the disorder.

== '''Clinical presentation''' ==
For most diseases, symptoms will vary from person to person. People with the same disease may not have all the symptoms listed.
80%-99% of people have these symptoms
* Increased bone mineral density(Increased bone density)

30%-79% of people have these symptoms
* Abnormal form of the vertebral bodies
* [[Kyphosis]](Hunched back)
* Sclerotic vertebral body
* [[Scoliosis]]

5%-29% of people have these symptoms
* Abnormal [[cortical bone]] morphology
* Abnormality of metabolism/[[homeostasis](Laboratory abnormality)

== '''Diagnosis''' ==
== '''Treatment''' ==

{{rarediseases}}
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Osteomesopyknosis - Revision history

Prab: CSV import

Deepika vegiraju: Created page with "== '''Alternate names''' == Axial osteosclerosis == '''Definition''' == Osteomesopyknosis is a bone disorder characterized by abnormal hardening of bone (osteosclerosis)...."