https://wikimd.org/index.php?action=history&feed=atom&title=Osteocalcin Osteocalcin - Revision history 2026-05-07T10:15:01Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=Osteocalcin&diff=6525481&oldid=prev Prab at 13:04, 18 March 2025 2025-03-18T13:04:48Z <p></p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 13:04, 18 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l33">Line 33:</td> <td colspan="2" class="diff-lineno">Line 33:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; 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font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">__NOINDEX__</del></div></td><td colspan="2" class="diff-side-added"></td></tr> </table> Prab https://wikimd.org/index.php?title=Osteocalcin&diff=6516188&oldid=prev Prab: CSV import 2025-03-17T21:29:07Z <p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:29, 17 March 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l33">Line 33:</td> <td colspan="2" class="diff-lineno">Line 33:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; 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white-space: pre-wrap;"><div>{{protein-stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr> </table> Prab https://wikimd.org/index.php?title=Osteocalcin&diff=5340149&oldid=prev Prab: CSV import 2024-03-02T02:56:39Z <p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;Osteocalcin&#039;&#039;&#039; (also known as &#039;&#039;&#039;bone gamma-carboxyglutamic acid-containing protein&#039;&#039;&#039; or &#039;&#039;&#039;BGLAP&#039;&#039;&#039;) is a non-collagenous protein hormone found in bone and dentin. It is secreted by [[osteoblasts]], the bone-forming cells, and is integral to the process of [[bone mineralization]] and calcium ion homeostasis. <br /> <br /> == Function ==<br /> <br /> Osteocalcin acts as a hormone in the body, regulating several metabolic pathways. It is involved in the process of bone mineralization, where it facilitates the binding of calcium ions to the bone matrix. This is crucial for the hardness and strength of bones. <br /> <br /> In addition to its role in bone health, osteocalcin also influences energy metabolism. It has been found to increase both insulin production and sensitivity, thus playing a role in glucose regulation. Furthermore, it has been linked to increased energy expenditure and fat loss.<br /> <br /> == Structure ==<br /> <br /> Osteocalcin is a small protein of 49 amino acids. It has a high affinity for calcium ions due to the presence of three gamma-carboxyglutamic acid residues. These residues are formed in a vitamin K-dependent carboxylation reaction, which is why adequate vitamin K is necessary for the function of osteocalcin.<br /> <br /> == Clinical significance ==<br /> <br /> Levels of osteocalcin in the blood are often used as a marker for bone formation and turnover. High levels can indicate increased bone turnover, as seen in conditions such as [[osteoporosis]] and [[hyperparathyroidism]]. Conversely, low levels can suggest reduced bone formation, which may occur in conditions like [[hypoparathyroidism]].<br /> <br /> Recent research has also suggested a link between osteocalcin levels and cardiovascular health. Higher levels of osteocalcin have been associated with a lower risk of [[atherosclerosis]], possibly due to its role in calcium regulation.<br /> <br /> == See also ==<br /> * [[Bone remodeling]]<br /> * [[Osteoblast]]<br /> * [[Osteoporosis]]<br /> * [[Vitamin K]]<br /> <br /> == References ==<br /> <br /> {{reflist}}<br /> <br /> [[Category:Protein]] <br /> [[Category:Hormones]] <br /> [[Category:Bone]] <br /> [[Category:Metabolism]] <br /> {{protein-stub}}</div> Prab