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	<title>Osmol gap - Revision history</title>
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	<updated>2026-04-25T16:02:28Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.org/index.php?title=Osmol_gap&amp;diff=6516007&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=Osmol_gap&amp;diff=6516007&amp;oldid=prev"/>
		<updated>2025-03-17T21:18:16Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 21:18, 17 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=Osmol_gap&amp;diff=6242095&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=Osmol_gap&amp;diff=6242095&amp;oldid=prev"/>
		<updated>2025-02-10T19:40:03Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 19:40, 10 February 2025&lt;/td&gt;
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		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=Osmol_gap&amp;diff=5206654&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=Osmol_gap&amp;diff=5206654&amp;oldid=prev"/>
		<updated>2024-02-22T04:06:29Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Osmol gap&amp;#039;&amp;#039;&amp;#039; is a diagnostic measure used in medicine to identify the presence of certain substances in the blood. It is calculated by subtracting the measured osmolality of a blood sample from the calculated osmolality. An elevated osmol gap can indicate the presence of certain toxins or substances in the blood, such as methanol or ethylene glycol.&lt;br /&gt;
&lt;br /&gt;
== Calculation ==&lt;br /&gt;
The osmol gap is calculated using the following formula:&lt;br /&gt;
&lt;br /&gt;
: Osmol gap = Measured osmolality - Calculated osmolality&lt;br /&gt;
&lt;br /&gt;
The calculated osmolality is typically determined using the concentrations of sodium, glucose, and blood urea nitrogen (BUN) in the blood. The formula for calculated osmolality is:&lt;br /&gt;
&lt;br /&gt;
: Calculated osmolality = 2 * [[Sodium]] (mEq/L) + [[Glucose]] (mg/dL) / 18 + [[BUN]] (mg/dL) / 2.8&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
An elevated osmol gap can indicate the presence of certain substances in the blood that are not accounted for in the calculated osmolality. These can include toxins such as [[methanol]], [[ethylene glycol]], or [[isopropanol]], as well as certain medications or substances used in medical treatments.&lt;br /&gt;
&lt;br /&gt;
In addition to its use in identifying the presence of these substances, the osmol gap can also be used to monitor the effectiveness of treatment for poisoning by these substances. A decreasing osmol gap can indicate that the treatment is effectively removing the substance from the blood.&lt;br /&gt;
&lt;br /&gt;
== Limitations ==&lt;br /&gt;
While the osmol gap is a useful diagnostic tool, it has some limitations. It is not specific for any particular substance, and an elevated osmol gap can be caused by a variety of factors. Additionally, the osmol gap can be affected by errors in the measurement or calculation of osmolality.&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
* [[Osmolality]]&lt;br /&gt;
* [[Blood urea nitrogen]]&lt;br /&gt;
* [[Methanol poisoning]]&lt;br /&gt;
* [[Ethylene glycol poisoning]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Medical tests]]&lt;br /&gt;
[[Category:Toxicology]]&lt;br /&gt;
[[Category:Biochemistry]]&lt;br /&gt;
&lt;br /&gt;
{{stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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