https://wikimd.org/index.php?action=history&feed=atom&title=Orexin_receptor
Orexin receptor - Revision history
2026-04-27T14:36:27Z
Revision history for this page on the wiki
MediaWiki 1.44.2
https://wikimd.org/index.php?title=Orexin_receptor&diff=6529037&oldid=prev
Prab at 17:37, 18 March 2025
2025-03-18T17:37:48Z
<p></p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 17:37, 18 March 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l39">Line 39:</td>
<td colspan="2" class="diff-lineno">Line 39:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr>
<tr><td class="diff-marker" data-marker="−"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;"><div><del style="font-weight: bold; text-decoration: none;">__NOINDEX__</del></div></td><td colspan="2" class="diff-side-added"></td></tr>
</table>
Prab
https://wikimd.org/index.php?title=Orexin_receptor&diff=6515999&oldid=prev
Prab: CSV import
2025-03-17T21:17:48Z
<p>CSV import</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:17, 17 March 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l39">Line 39:</td>
<td colspan="2" class="diff-lineno">Line 39:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{No image}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">__NOINDEX__</ins></div></td></tr>
</table>
Prab
https://wikimd.org/index.php?title=Orexin_receptor&diff=6276499&oldid=prev
Prab: CSV import
2025-02-11T04:37:45Z
<p>CSV import</p>
<table style="background-color: #fff; color: #202122;" data-mw="interface">
<col class="diff-marker" />
<col class="diff-content" />
<col class="diff-marker" />
<col class="diff-content" />
<tr class="diff-title" lang="en">
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td>
<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 04:37, 11 February 2025</td>
</tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l38">Line 38:</td>
<td colspan="2" class="diff-lineno">Line 38:</td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr>
<tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{medicine-stub}}</div></td></tr>
<tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">{{No image}}</ins></div></td></tr>
</table>
Prab
https://wikimd.org/index.php?title=Orexin_receptor&diff=5329906&oldid=prev
Prab: CSV import
2024-02-29T03:35:09Z
<p>CSV import</p>
<p><b>New page</b></p><div>'''Orexin receptor''' is a type of [[G protein-coupled receptor]] that is activated by the [[neuropeptide]]s orexin A and orexin B. These receptors are primarily located in the [[central nervous system]], where they play a crucial role in regulating [[sleep-wake cycle]], [[appetite]], and [[energy homeostasis]]. There are two types of orexin receptors: [[Orexin receptor type 1]] (OX1R) and [[Orexin receptor type 2]] (OX2R).<br />
<br />
== Structure ==<br />
<br />
Like other G protein-coupled receptors, orexin receptors have seven transmembrane domains. The binding site for orexin A and B is located in the extracellular loop of the receptor. The intracellular loops and the C-terminal tail of the receptor are involved in signal transduction.<br />
<br />
== Function ==<br />
<br />
Orexin receptors are activated by the neuropeptides orexin A and B, which are produced by neurons in the [[hypothalamus]]. Activation of these receptors promotes wakefulness and energy expenditure. They also play a role in the regulation of appetite, with increased activation of orexin receptors leading to increased food intake.<br />
<br />
== Clinical significance ==<br />
<br />
Mutations in the genes encoding orexin receptors can lead to [[narcolepsy]], a sleep disorder characterized by excessive daytime sleepiness and sudden episodes of muscle weakness. In addition, orexin receptors have been implicated in the regulation of [[mood disorders]], [[addiction]], and [[metabolic syndrome]].<br />
<br />
== Therapeutic potential ==<br />
<br />
Due to their role in sleep regulation, orexin receptors are a potential target for the treatment of sleep disorders such as insomnia and narcolepsy. Several orexin receptor antagonists are currently under development for this purpose. In addition, orexin receptors may also be a potential target for the treatment of obesity and other metabolic disorders, due to their role in regulating energy homeostasis.<br />
<br />
== See also ==<br />
* [[Orexin]]<br />
* [[G protein-coupled receptor]]<br />
* [[Neuropeptide]]<br />
* [[Sleep-wake cycle]]<br />
* [[Appetite]]<br />
* [[Energy homeostasis]]<br />
<br />
[[Category:G protein-coupled receptors]]<br />
[[Category:Neurotransmitter receptors]]<br />
[[Category:Sleep]]<br />
[[Category:Appetite]]<br />
[[Category:Energy homeostasis]]<br />
<br />
{{G protein-coupled receptors}}<br />
{{Neurotransmitter receptors}}<br />
{{Sleep}}<br />
{{Appetite}}<br />
{{Energy homeostasis}}<br />
<br />
{{medicine-stub}}</div>
Prab