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<p><b>New page</b></p><div>[[File:Opiorphin.png|thumb|{{PAGENAME}}]]<br>'''Opiorphin''' is a [[peptide]] that was first isolated from human [[saliva]]. It is a relatively small molecule, consisting of only five [[amino acids]], but it has been found to have potent [[analgesic]] properties. <br />
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==Discovery==<br />
Opiorphin was discovered in 2006 by a team of researchers led by [[Catherine Rougeot]] at the [[Institut Pasteur]] in [[Paris]], [[France]]. The team was investigating the analgesic properties of human saliva when they isolated the peptide.<br />
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==Structure and Function==<br />
Opiorphin is a pentapeptide, meaning it is composed of five amino acids. These are [[glutamine]], [[arginine]], [[proline]], [[arginine]], and [[proline]] (QRPRL). The peptide is synthesized in the [[salivary glands]] and secreted into the saliva.<br />
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The primary function of opiorphin is to inhibit the breakdown of [[enkephalins]], which are endogenous [[opioid peptides]]. It does this by inhibiting two enzymes, [[neutral endopeptidase]] (NEP) and [[aminopeptidase N]] (APN), which are responsible for degrading enkephalins. By preventing the breakdown of these peptides, opiorphin increases their concentration in the body, leading to increased analgesic effects.<br />
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==Potential Therapeutic Uses==<br />
Due to its analgesic properties, opiorphin has potential for use in the treatment of [[pain]]. In animal studies, it has been found to be as effective as [[morphine]] in relieving pain, but without the side effects associated with opioid drugs. However, further research is needed to determine its safety and efficacy in humans.<br />
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==See Also==<br />
* [[Peptide]]<br />
* [[Analgesic]]<br />
* [[Enkephalin]]<br />
* [[Opioid peptide]]<br />
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[[Category:Peptides]]<br />
[[Category:Analgesics]]<br />
[[Category:Biochemistry]]<br />
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