https://wikimd.org/index.php?action=history&feed=atom&title=Open_reading_frameOpen reading frame - Revision history2026-05-11T09:28:56ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Open_reading_frame&diff=6308213&oldid=prevPrab: CSV import2025-02-17T02:10:06Z<p>CSV import</p>
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<p><b>New page</b></p><div>'''Open Reading Frame'''<br />
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An '''Open Reading Frame''' (ORF) is a sequence of [[DNA]] or [[RNA]] that has the potential to be translated into a protein. The sequence starts with a [[start codon]] (ATG in DNA or AUG in RNA) and ends with one of the three [[stop codon]]s (TAA, TAG, or TGA in DNA; UAA, UAG, or UGA in RNA). <br />
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==Definition==<br />
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In molecular genetics, an ORF is a stretch of the DNA sequence that is transcribed into RNA and translated into a protein. The ORF contains the information to make a protein product, and it is the part of the gene that is translated.<br />
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==Identification==<br />
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ORFs are identified by scanning the genome for specific sequences that indicate the start and stop of genes. The start codon, usually AUG (or ATG in DNA), signifies the start of the ORF. The sequence continues until a stop codon (UAA, UAG, or UGA in RNA; TAA, TAG, or TGA in DNA) is encountered.<br />
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==Function==<br />
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The function of the protein encoded by an ORF can often be predicted by comparing the predicted amino acid sequence to those of known proteins in other organisms. In this way, ORFs are used to identify potential protein-coding genes within a sequence of DNA.<br />
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==See also==<br />
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* [[Gene]]<br />
* [[Protein biosynthesis]]<br />
* [[Genetic code]]<br />
* [[Transcription (genetics)]]<br />
* [[Translation (biology)]]<br />
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==References==<br />
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<references /><br />
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[[Category:Genetics]]<br />
[[Category:Molecular biology]]<br />
[[Category:Bioinformatics]]<br />
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