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	'''Oncostatin M''' (OSM) is a [[~~protein~~]] ~~that in humans is encoded by the OSM gene. It is a member of~~ the [[interleukin 6]] (IL-6) ~~group~~ of [[~~cytokine~~]]~~s which are involved~~ in the ~~regulation of~~ [[~~cell growth~~]] and [[~~differentiation~~]].		== Oncostatin M ==

			[[File:hosm.jpg\|thumb\|right\|Oncostatin M structure]]

			'''Oncostatin M''' (OSM) is a [[cytokine]] belonging to the [[interleukin-6]] (IL-6) family, which plays a significant role in the regulation of [[inflammation]], [[hematopoiesis]], and [[oncogenesis]]. It is produced by a variety of cells, including [[activated T cells]], [[macrophages]], and [[dendritic cells]].

			== Structure ==

			Oncostatin M is a glycoprotein with a molecular weight of approximately 28 kDa. It is encoded by the [[OSM gene]] located on chromosome 22 in humans. The protein consists of 209 amino acids and shares structural similarities with other members of the IL-6 family, such as [[leukemia inhibitory factor]] (LIF) and [[ciliary neurotrophic factor]] (CNTF).

	== Function ==		== Function ==

	Oncostatin M ~~is a growth regulator which inhibits the proliferation of a number of~~ [[~~tumor cell~~]] ~~lines~~. It ~~stimulates controlled growth of~~ [[~~cancer cells~~]] and ~~promotes differentiation of a variety of cell types, including~~ [[~~leukemia~~]] ~~cells~~, [[~~fibroblast~~]]s and ~~[[neuronal cells]]~~.		Oncostatin M exerts its effects by binding to specific [[receptors]] on the surface of target cells. It primarily signals through the [[OSM receptor]] (OSMR) and the [[gp130]] receptor subunit, which are shared with other cytokines in the IL-6 family. Upon binding, OSM activates the [[JAK-STAT signaling pathway]], leading to the transcription of various genes involved in cell proliferation, differentiation, and survival.

	== ~~Structure~~ ==		=== Role in Inflammation ===

			OSM is a potent mediator of [[inflammatory responses]]. It can induce the expression of [[acute phase proteins]] and [[pro-inflammatory cytokines]] such as [[interleukin-1]] (IL-1) and [[tumor necrosis factor-alpha]] (TNF-_). OSM also enhances the recruitment of [[leukocytes]] to sites of inflammation by upregulating the expression of [[adhesion molecules]] on [[endothelial cells]].

			=== Role in Hematopoiesis ===

			In the context of [[hematopoiesis]], OSM supports the proliferation and differentiation of [[hematopoietic stem cells]] and progenitor cells. It has been shown to synergize with other cytokines like [[granulocyte colony-stimulating factor]] (G-CSF) to promote the development of [[myeloid]] and [[erythroid]] lineages.

	~~The OSM gene is located on the long arm of [[chromosome 22]] (22q12.2). The protein encoded by this gene is a secreted [[glycoprotein]] that is approximately 28 kDa~~ in ~~size. It is composed of 227 [[amino acids]] and has a four-helix bundle structure, similar to other members of the IL-6 family.~~		=== Role in Oncogenesis ===

	~~== Clinical significance ==~~		OSM has a dual role in [[cancer]]. It can inhibit the growth of certain [[tumor]] cells, such as [[melanoma]] and [[breast cancer]] cells, by inducing [[cell cycle arrest]] and [[apoptosis]]. However, in other contexts, OSM may promote [[tumor progression]] and [[metastasis]] by enhancing [[angiogenesis]] and [[extracellular matrix]] remodeling.

	Oncostatin M has been implicated in a number of physiological processes, including [[inflammation]], [[hematopoiesis]], and [[bone remodeling]]. It has also been associated with several pathological conditions, such as [[rheumatoid arthritis]], [[asthma]], and certain types of [[cancer]].		== Clinical Implications ==

	~~== Research ==~~		Due to its involvement in various physiological and pathological processes, OSM is a potential target for therapeutic intervention. Modulating OSM activity could be beneficial in treating [[inflammatory diseases]], [[autoimmune disorders]], and certain types of cancer. However, the complex and context-dependent nature of OSM's effects necessitates careful consideration in the development of OSM-targeted therapies.

	Research into Oncostatin M has focused on its potential therapeutic applications, particularly in the treatment of cancer. Studies have shown that OSM can inhibit the growth of certain types of cancer cells, suggesting that it may have potential as a novel [[anticancer]] therapy.		== Related pages ==

	~~== See also ==~~
	* [[Cytokine]]		* [[Cytokine]]
	* [[Interleukin 6]]		* [[Interleukin-6]]
	* [[~~Cell growth~~]]		* [[JAK-STAT signaling pathway]]
	* [[~~Cell differentiation~~]]		* [[Hematopoiesis]]
	* [[~~Cancer~~]]		* [[Oncogenesis]]

	~~[[Category:Proteins]]~~
	[[Category:Cytokines]]		[[Category:Cytokines]]
	~~[[Category:Cell biology]]~~
	~~[[Category:Cancer]]~~
	~~{{protein-stub}}~~
	~~{{medicine-stub}}~~

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2024-02-29T05:10:04Z

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'''Oncostatin M''' (OSM) is a [[protein]] that in humans is encoded by the OSM gene. It is a member of the [[interleukin 6]] (IL-6) group of [[cytokine]]s which are involved in the regulation of [[cell growth]] and [[differentiation]].

== Function ==

Oncostatin M is a growth regulator which inhibits the proliferation of a number of [[tumor cell]] lines. It stimulates controlled growth of [[cancer cells]] and promotes differentiation of a variety of cell types, including [[leukemia]] cells, [[fibroblast]]s and [[neuronal cells]].

== Structure ==

The OSM gene is located on the long arm of [[chromosome 22]] (22q12.2). The protein encoded by this gene is a secreted [[glycoprotein]] that is approximately 28 kDa in size. It is composed of 227 [[amino acids]] and has a four-helix bundle structure, similar to other members of the IL-6 family.

== Clinical significance ==

Oncostatin M has been implicated in a number of physiological processes, including [[inflammation]], [[hematopoiesis]], and [[bone remodeling]]. It has also been associated with several pathological conditions, such as [[rheumatoid arthritis]], [[asthma]], and certain types of [[cancer]].

== Research ==

Research into Oncostatin M has focused on its potential therapeutic applications, particularly in the treatment of cancer. Studies have shown that OSM can inhibit the growth of certain types of cancer cells, suggesting that it may have potential as a novel [[anticancer]] therapy.

== See also ==
* [[Cytokine]]
* [[Interleukin 6]]
* [[Cell growth]]
* [[Cell differentiation]]
* [[Cancer]]

[[Category:Proteins]]
[[Category:Cytokines]]
[[Category:Cell biology]]
[[Category:Cancer]]
{{protein-stub}}
{{medicine-stub}}

Oncostatin M - Revision history

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