Prab at 01:58, 4 March 2025

2025-03-04T01:58:30Z

← Older revision		Revision as of 01:58, 4 March 2025
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	~~== '''What Is Oliceridine?''' ==~~
	Oliceridine (OLINVYK) is an [[opioid]] [[agonist]].		Oliceridine (OLINVYK) is an [[opioid]] [[agonist]].

	[[File:Oliceridine2DCSD.svg\|thumb]]		[[File:Oliceridine2DCSD.svg\|thumb]]

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	== '''What are the uses of this medicine?''' ==		== '''What are the uses of this medicine?''' ==

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Prab at 16:48, 2 July 2021

2021-07-02T16:48:02Z

New page

== '''What Is Oliceridine?''' ==
Oliceridine (OLINVYK) is an [[opioid]] [[agonist]].

[[File:Oliceridine2DCSD.svg|thumb]]

<youtube>
title='''{{PAGENAME}}'''
movie_url=http://www.youtube.com/v/=YmNxt2J-7iM
embed_source_url=http://www.youtube.com/v/=YmNxt2J-7iM
&rel=1
wrap = yes
width=750
height=600
</youtube>

== '''What are the uses of this medicine?''' ==

* This medicine is indicated in adults for the management of [[acute pain]] severe enough to require an intravenous [[opioid]] [[analgesic]] and for whom alternative treatments are inadequate.

== '''How does this medicine work?''' ==

* Oliceridine is a '''full opioid agonist and is relatively selective for the mu-opioid receptor'''.
* The principal therapeutic action of oliceridine is [[analgesia]].
* The precise mechanism of the analgesic action is unknown.
* However,''' specific CNS opioid receptors for endogenous compounds with opioid-like activity have been identified''' throughout the brain and spinal cord and are thought to play a role in the analgesic effects of this drug.

== '''Who Should Not Use this medicine ?''' ==

This medicine cannot be used in patients with:
* Significant respiratory depression
* Acute or severe [[bronchial asthma]] in an unmonitored setting or in the absence of resuscitative equipment
* Known or suspected gastrointestinal obstruction, including paralytic [[ileus]]
* Known [[hypersensitivity]] to [[oliceridine]] (e.g., anaphylaxis)

== '''Is this medicine FDA approved?''' ==

* It was approved for use in the United States in 2020.

== '''How should this medicine be used?''' ==

* Individualize dosing based on the severity of pain, patient response, prior analgesic experience, and risk factors for addiction, abuse, and misuse.
* Initiate treatment with a 1.5 mg dose.
* For patient controlled analgesia (PCA), recommended demand dose is 0.35 mg, with a 6-minute lock-out.
* A demand dose of 0.5 mg may be considered.
* Supplemental doses of 0.75 mg can be administered, beginning 1 hour after the initial dose, and hourly thereafter, as needed.
* Do not stop OLINVYK in a physically-dependent patient.
* Taper the dose gradually while monitoring carefully for signs and symptoms of withdrawal.

== '''What are the dosage forms and brand names of this medicine?''' ==

This medicine is available in fallowing doasage form:
'''As Injection:'''
* 1 mg/mL and 2 mg/2 ml (1 mg/mL) in single-dose vials
* 30 mg/30 mL (1 mg/mL) in single-patient-use vial, For PCA Use Only

This medicine is available in fallowing brand namesː
* '''OLINVYK'''

=='''What side effects can this medication cause?'''==

Common possible side effects of this medicine include:
* nausea
* vomiting
* dizziness
* headache
* constipation
* [[pruritus]]
* [[hypoxia]]

==''' What special precautions should I follow?''' ==

* Do not exceed a cumulative daily dose of 27 mg, it may increase risk for QT interval prolongation.
* Monitor closely, life-threatening respiratory depression in Patients with Chronic Pulmonary Disease or in Elderly, Cachectic, or Debilitated Patients particularly during initiation and titration.
* If adrenal Insufficiency is diagnosed, treat with physiologic replacement [[corticosteroids]] and wean the patient off the [[opioid]].
* Avoid use of OLINVYK in patients with circulatory shock.
* Monitor for signs of sedation and [[respiratory depression]].
* Avoid the use of OLINVYK in patients with impaired consciousness or [[coma]].

== '''What to do in case of emergency/overdose?''' ==

* Acute overdose with OLINVYK can be manifested by respiratory depression, somnolence progressing to stupor or coma, skeletal muscle flaccidity, cold and clammy skin, constricted pupils, and, in some cases, [[pulmonary edema]], [[bradycardia]], [[hypotension]], partial or complete airway obstruction, atypical snoring, and death.

'''Treatment for overdosage:'''
* In case of overdose, priorities are the reestablishment of a patent and protected airway and institution of assisted or controlled ventilation, if needed. Employ other supportive measures (including oxygen and [[vasopressors]]) in the management of circulatory shock and [[pulmonary edema]] as indicated.
* [[Cardiac arrest]] or [[arrhythmias]] will require advanced life-support techniques.
* The [[opioid antagonist]], [[naloxone]], is a specific [[antidote]] for [[respiratory depression]] resulting from [[opioid]] overdose.

== '''Can this medicine be used in pregnancy?''' ==

* There are no available data on OLINVYK use in pregnant women to evaluate for a drug-associated risk of major birth defects and miscarriage.
* Prolonged use of opioid analgesics during pregnancy may result in neonatal opioid withdrawal syndrome.

=='''Can this medicine be used in children?'''==

* The safety and effectiveness of OLINVYK in pediatric patients has not been established.

== '''What should I know about storage and disposal of this medication?''' ==

* Store at controlled room temperature 20°-25°C (68°-77°F); excursions permitted to 15°-30°C (59°-86°F).
* Protect from freezing.
* Protect from light.
{{coststubd}}
{{Analgesics}}
{{Opioid receptor modulators}}
{{Portal bar | Medicine}}

[[Category:Analgesics]]
[[Category:Biased ligands]]
[[Category:Mu-opioid agonists]]
[[Category:Pyridines]]
[[Category:Spiro compounds]]
[[Category:Thiophenes]]

{{pharma-stub}}

Oliceridine - Revision history

Prab at 01:58, 4 March 2025

Prab at 16:48, 2 July 2021