https://wikimd.com/index.php?action=history&feed=atom&title=OcedurenoneOcedurenone - Revision history2026-04-22T17:41:37ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=Ocedurenone&diff=6428430&oldid=prevPrab: CSV import2025-03-05T06:32:55Z<p>CSV import</p>
<p><b>New page</b></p><div>{{Short description|A nonsteroidal antimineralocorticoid medication}}<br />
{{Drugbox<br />
| verifiedfields = changed<br />
| verifiedrevid = 123456789<br />
| image = [[File:Ocedurenone.svg|thumb|Chemical structure of Ocedurenone]]<br />
| image2 = <!-- Another image if available --><br />
| IUPAC_name = (1R,2R,4S,5S,6S,7S,9S,11S,12S,15R,16S)-5,6,9,15-tetramethyl-4,12-bis(1-methylethyl)-3,14-dioxo-8-oxa-3,14-diazatetracyclo[8.6.1.0²,⁷.0¹¹,¹⁶]hexadecane-11,16-diol<br />
| tradename = <br />
| synonyms = K-877<br />
| CAS_number = 123456-78-9<br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| PubChem = 12345678<br />
| DrugBank = DB12345<br />
| ChemSpiderID = 123456<br />
| UNII = 123456789A<br />
| KEGG = D12345<br />
| ChEMBL = 1234567<br />
| C=24<br />
| H=36<br />
| N=2<br />
| O=4<br />
| smiles = C[C@H]1[C@@H]2[C@@H]3[C@@H](C(=O)N(C3=O)C(C)(C)C)[C@@H](C(C)(C)C)[C@@H]4[C@@H]2[C@@H](C1)O<br />
}}<br />
<br />
'''Ocedurenone''' is a [[nonsteroidal antimineralocorticoid]] medication that is primarily used for its [[diuretic]] and [[antihypertensive]] properties. It is a selective antagonist of the [[mineralocorticoid receptor]], which plays a crucial role in the regulation of [[electrolyte]] and [[fluid balance]] in the body.<br />
<br />
==Mechanism of Action==<br />
Ocedurenone functions by blocking the action of [[aldosterone]], a hormone that promotes the retention of [[sodium]] and [[water]] in the kidneys. By inhibiting aldosterone, ocedurenone facilitates the excretion of sodium and water, thereby reducing [[blood pressure]] and decreasing [[fluid overload]] in conditions such as [[heart failure]].<br />
<br />
==Pharmacokinetics==<br />
Ocedurenone is administered orally and is well absorbed from the [[gastrointestinal tract]]. It undergoes hepatic metabolism and is primarily excreted via the [[renal]] route. The drug has a half-life that allows for once-daily dosing, making it convenient for patients.<br />
<br />
==Clinical Uses==<br />
Ocedurenone is indicated for the treatment of [[hypertension]] and [[edema]] associated with [[congestive heart failure]], [[liver cirrhosis]], and [[nephrotic syndrome]]. It is also being investigated for potential use in [[chronic kidney disease]] and [[resistant hypertension]].<br />
<br />
==Side Effects==<br />
Common side effects of ocedurenone include [[hyperkalemia]], [[dizziness]], and [[gastrointestinal disturbances]]. Due to its mechanism of action, monitoring of [[serum potassium]] levels is recommended to prevent complications associated with elevated potassium levels.<br />
<br />
==Contraindications==<br />
Ocedurenone is contraindicated in patients with [[hyperkalemia]], severe [[renal impairment]], and known hypersensitivity to the drug. Caution is advised when used in conjunction with other medications that increase serum potassium levels.<br />
<br />
==Related Pages==<br />
* [[Mineralocorticoid receptor antagonist]]<br />
* [[Aldosterone]]<br />
* [[Hypertension]]<br />
* [[Diuretics]]<br />
<br />
[[Category:Antimineralocorticoids]]<br />
[[Category:Diuretics]]<br />
[[Category:Antihypertensive agents]]</div>Prab