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	'''OR51E2~~''' also known as '''Olfactory Receptor Family 51 Subfamily E Member 2~~''' is a protein that in humans is encoded by the OR51E2 gene. It is a member of the [[olfactory receptor]] family of ~~genes~~, which are the ~~largest gene family in~~ the ~~genome~~.		== OR51E2 ==

			[[File:OR51E2.png\|thumb\|right\|Diagram of the OR51E2 receptor structure]]

			'''OR51E2''' is a [[protein]] that in humans is encoded by the '''OR51E2''' [[gene]]. This protein is a member of the [[olfactory receptor]] family, which is responsible for the detection of odor molecules. Olfactory receptors are a type of [[G protein-coupled receptor]] (GPCR), which are involved in various signal transduction pathways.

			== Structure ==

			OR51E2, like other olfactory receptors, has a characteristic structure that includes seven transmembrane [[alpha helices]]. These helices span the [[cell membrane]], allowing the receptor to interact with odorant molecules outside the cell and initiate a signal transduction cascade inside the cell.

	== Function ==		== Function ==
	The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

	~~== Clinical significance ==~~		The primary function of OR51E2 is to detect specific odorant molecules and initiate a neuronal response that results in the perception of smell. This receptor is expressed in the [[olfactory epithelium]], a specialized tissue inside the nasal cavity. When an odorant binds to OR51E2, it activates the associated G protein, which then triggers a series of intracellular events leading to the generation of an [[action potential]] in the olfactory sensory neuron.
	OR51E2 is ~~also known as~~ a [[~~prostate-specific~~ G-protein ~~coupled receptor~~]] ~~(PSGR)~~, ~~and~~ has been found ~~to be upregulated~~ in ~~prostate cancer~~. ~~It has been suggested that~~ OR51E2 may be ~~a useful target for the treatment of prostate cancer~~.
			== Expression ==

			OR51E2 is predominantly expressed in the olfactory epithelium, but it has also been found in other tissues, suggesting potential roles beyond olfaction. The expression of OR51E2 in non-olfactory tissues is an area of active research, as it may be involved in various physiological processes.

			== Related pages ==

	~~== See also ==~~
	* [[Olfactory receptor]]		* [[Olfactory receptor]]
	* [[G protein-coupled receptor]]		* [[G protein-coupled receptor]]
	* [[~~Prostate cancer~~]]		* [[Signal transduction]]
			* [[Olfactory system]]
	~~== References ==~~
	~~<references />~~

	~~== External links ==~~
	* [~~https://www.ncbi.nlm.nih.gov/gene/219931 GeneCards: OR51E2~~]

	~~[[Category:G protein-coupled receptors]]~~
	[[Category:Olfactory receptors]]		[[Category:Olfactory receptors]]
	~~[[Category:Human proteins]]~~
	~~[[Category:Genes on human chromosome 11]]~~
	~~{{GPCR-stub}}~~
	~~{{medicine-stub}}~~

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'''OR51E2''' also known as '''Olfactory Receptor Family 51 Subfamily E Member 2''' is a protein that in humans is encoded by the OR51E2 gene. It is a member of the [[olfactory receptor]] family of genes, which are the largest gene family in the genome.

== Function ==
The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

== Clinical significance ==
OR51E2 is also known as a [[prostate-specific G-protein coupled receptor]] (PSGR), and has been found to be upregulated in prostate cancer. It has been suggested that OR51E2 may be a useful target for the treatment of prostate cancer.

== See also ==
* [[Olfactory receptor]]
* [[G protein-coupled receptor]]
* [[Prostate cancer]]

== References ==
<references />

== External links ==
* [https://www.ncbi.nlm.nih.gov/gene/219931 GeneCards: OR51E2]

[[Category:G protein-coupled receptors]]
[[Category:Olfactory receptors]]
[[Category:Human proteins]]
[[Category:Genes on human chromosome 11]]
{{GPCR-stub}}
{{medicine-stub}}

OR51E2 - Revision history

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