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	'''OR4N4''' is a gene that encodes the olfactory receptor, family 4, subfamily N, member 4 in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

	==~~Structure~~==		{{Infobox gene
	~~The OR4N4 gene is located on the [[chromosome 1]] (1q44) and spans approximately 1~~.1 ~~kb. The gene encodes a protein of 312 amino acids with a predicted molecular weight of approximately 34.5 kDa.~~		\| name = OR4N4
			\| symbol = OR4N4
			\| HGNCid = 14857
			\| chromosome = 15
			\| arm = q
			\| band = 11.2
			\| locus = 1
			}}

	~~==Function==~~		'''OR4N4''' is a gene that encodes a member of the olfactory receptor family of proteins. These proteins are part of the [[G protein-coupled receptor]] (GPCR) superfamily, which are responsible for detecting odorants and initiating the sense of [[smell]].
	~~The protein encoded by~~ OR4N4 is ~~an olfactory receptor, expressed in the [[olfactory epithelium]] and is involved in the detection of odorants. Olfactory receptors interact with odorant molecules in the nose, to initiate~~ a ~~neuronal response~~ that ~~triggers~~ the ~~perception~~ of ~~a smell~~. ~~The olfactory receptor~~ proteins are ~~members of a large family~~ of G-~~protein~~ coupled ~~receptors~~ (GPCR) ~~arising from single coding-exon genes~~.

	==~~Clinical Significance~~==		== Function ==
	~~While the specific clinical significance of OR4N4 is not well understood~~, ~~olfactory receptors in general are thought to have roles in various diseases~~ such as ~~[[neurodegenerative diseases]]~~, [[~~cancer~~]], ~~and certain [[genetic disorders]]. Further research~~ is ~~needed to elucidate the potential roles~~ of ~~OR4N4 in human health~~ and ~~disease~~.		Olfactory receptors, such as OR4N4, interact with odorant molecules in the [[olfactory epithelium]] of the nose to initiate a neuronal response that results in the perception of smell. The olfactory receptor proteins are characterized by a 7-transmembrane domain structure, which is a common feature of many neurotransmitter and hormone receptors.

	~~[[File:OR4N4~~ gene ~~location on~~ human ~~chromosome 1~~.~~png\|thumb\|right\|300px\|Location of~~ OR4N4 gene on ~~human~~ chromosome 1.]]		== Gene Family ==
			The olfactory receptor gene family is the largest in the human genome. The OR4N4 gene is one of many olfactory receptor genes located on [[chromosome 15]]. These genes are expressed in a spatially and temporally regulated manner, contributing to the diversity of odorant detection.

	==See Also==		== Pathways ==
			OR4N4 is involved in the [[olfactory signaling pathway]], which is crucial for the detection and processing of odorant signals. This pathway involves the binding of odorants to receptors, activation of G proteins, and subsequent signal transduction leading to neuronal activation.

			== Clinical Significance ==
			While specific clinical implications of OR4N4 are not well-documented, variations in olfactory receptor genes can influence [[olfactory perception]] and have been studied in the context of [[anosmia]] and other olfactory disorders.

			== Research ==
			Research on olfactory receptors like OR4N4 continues to explore their role in [[sensory biology]] and potential implications in [[neurological disorders]]. Understanding the genetic basis of olfaction can provide insights into [[human evolution]] and [[genetic diversity]].

			== See Also ==
	* [[Olfactory receptor]]		* [[Olfactory receptor]]
	* [[G protein-coupled receptor]]		* [[G protein-coupled receptor]]
	* [[Chromosome 1]]		* [[Chromosome 15]]

	==References==		== References ==
	<references/>		<references/>

	[[Category:Genes on human chromosome 1]]		== External Links ==
			* [https://www.ncbi.nlm.nih.gov/gene/OR4N4 OR4N4 Gene - NCBI]
			* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR4N4 OR4N4 Gene - GeneCards]

			[[Category:Genes on human chromosome 15]]
	[[Category:Olfactory receptors]]		[[Category:Olfactory receptors]]
	[[Category:G protein-coupled receptors]]		[[Category:G protein-coupled receptors]]

	~~{{medicine-stub}}~~

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'''OR4N4''' is a gene that encodes the olfactory receptor, family 4, subfamily N, member 4 in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

==Structure==
The OR4N4 gene is located on the [[chromosome 1]] (1q44) and spans approximately 1.1 kb. The gene encodes a protein of 312 amino acids with a predicted molecular weight of approximately 34.5 kDa.

==Function==
The protein encoded by OR4N4 is an olfactory receptor, expressed in the [[olfactory epithelium]] and is involved in the detection of odorants. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes.

==Clinical Significance==
While the specific clinical significance of OR4N4 is not well understood, olfactory receptors in general are thought to have roles in various diseases such as [[neurodegenerative diseases]], [[cancer]], and certain [[genetic disorders]]. Further research is needed to elucidate the potential roles of OR4N4 in human health and disease.

[[File:OR4N4 gene location on human chromosome 1.png|thumb|right|300px|Location of OR4N4 gene on human chromosome 1.]]

==See Also==
* [[Olfactory receptor]]
* [[G protein-coupled receptor]]
* [[Chromosome 1]]

==References==
<references/>

[[Category:Genes on human chromosome 1]]
[[Category:Olfactory receptors]]
[[Category:G protein-coupled receptors]]

{{medicine-stub}}

OR4N4 - Revision history

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