Prab: CSV import

2024-12-30T20:33:53Z

CSV import

← Older revision		Revision as of 20:33, 30 December 2024
Line 1:		Line 1:
	'''OR4N2''' is a gene that encodes the olfactory receptor, family 4, subfamily N, member 2 protein in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

	~~[[File:OR4N2~~ gene ~~location on human chromosome.png~~\|~~thumb~~\|~~Location of~~ OR4N2 ~~gene on human~~ chromosome]]		{{Infobox gene
			\| name = OR4N2
			\| symbol = OR4N2
			\| HGNCid = 15006
			\| chromosome = 15
			\| arm = q
			\| band = 11.2
			\| locus = 15q11.2
			}}

	~~== Function ==~~		'''OR4N2''' is a gene that encodes a member of the [[olfactory receptor]] family of proteins. These receptors are part of the [[G protein-coupled receptor]] (GPCR) superfamily, which are responsible for detecting odor molecules and initiating the sense of [[smell]].

	~~The~~ OR4N2 ~~gene is part of~~ the [[~~olfactory receptor~~]] ~~gene family~~, ~~which is the largest gene family~~ in the ~~human genome~~. The proteins ~~encoded~~ by ~~these genes are responsible for the recognition and transduction of odorant signals~~, which ~~are mediated by G proteins. The OR4N2 protein~~ is ~~one~~ of ~~these olfactory~~ receptors ~~and is specifically involved in the detection of certain odors~~.		==Function==
			Olfactory receptors, such as OR4N2, interact with odorant molecules in the [[nasal epithelium]], triggering a neuronal response that results in the perception of smell. The olfactory receptor proteins are characterized by a 7-transmembrane domain structure, which is a common feature of many neurotransmitter and hormone receptors.

	~~== Structure ==~~		The OR4N2 gene is part of the largest gene family in the human genome, which is responsible for the diversity of olfactory receptors. These receptors are crucial for the detection of a wide range of odorant molecules, allowing humans to perceive a vast array of smells.

	The OR4N2 gene is located on ~~the~~ [[chromosome 1]] ~~(1q44) and~~ is ~~composed~~ of ~~a single coding exon~~. The ~~protein encoded by this gene~~ is ~~a member of~~ the ~~G-protein coupled receptor 1 family and has 7 transmembrane domains~~, a ~~characteristic structure~~ of ~~many neurotransmitter and hormone receptors~~.		==Genomics==
			The OR4N2 gene is located on [[chromosome 15]] at the 15q11.2 locus. It is one of many olfactory receptor genes that are distributed throughout the human genome. The expression of these genes is highly specific to the olfactory epithelium, where they play a critical role in the sense of smell.

	== Clinical Significance ==		==Clinical Significance==
			While the primary function of OR4N2 is related to olfaction, variations in olfactory receptor genes can influence individual differences in odor perception. However, specific clinical conditions directly associated with mutations in the OR4N2 gene have not been extensively documented.

	~~While~~ the ~~exact role~~ of ~~OR4N2 in disease is not fully understood,~~ olfactory receptors ~~in general~~ have ~~been implicated in various diseases, including~~ [[neurodegenerative diseases]] ~~like [[Parkinson's disease]] and [[Alzheimer's disease]], as well as certain types~~ of ~~[[cancer]]~~.		==Research==
			Research into olfactory receptors like OR4N2 continues to provide insights into the mechanisms of smell and the genetic basis of olfactory perception. Understanding these receptors can also have implications for the development of artificial sensing devices and the study of [[neurodegenerative diseases]] where the sense of smell is often affected.

	== ~~Research~~ ==		==See Also==
			* [[Olfactory system]]
			* [[G protein-coupled receptor]]
			* [[Chromosome 15]]

	Research into the OR4N2 gene and its associated protein is ongoing, with studies focusing on its role in odor detection and potential involvement in disease. Understanding the function of this and other olfactory receptors may provide insights into the mechanisms of smell and disease pathogenesis.		==References==
			<references/>

	[[Category:Genes]]		==External Links==
	[[Category:~~Human proteins~~]]		* [https://www.ncbi.nlm.nih.gov/gene/OR4N2 OR4N2 Gene - NCBI]
			* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR4N2 OR4N2 Gene - GeneCards]

			[[Category:Genes on human chromosome 15]]
			[[Category:Olfactory receptors]]
	[[Category:G protein-coupled receptors]]		[[Category:G protein-coupled receptors]]
	~~[[Category:Olfactory system]]~~
	~~{{medicine-stub}}~~

Prab: CSV import

2024-03-10T06:58:55Z

CSV import

New page

'''OR4N2''' is a gene that encodes the olfactory receptor, family 4, subfamily N, member 2 protein in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

[[File:OR4N2 gene location on human chromosome.png|thumb|Location of OR4N2 gene on human chromosome]]

== Function ==

The OR4N2 gene is part of the [[olfactory receptor]] gene family, which is the largest gene family in the human genome. The proteins encoded by these genes are responsible for the recognition and transduction of odorant signals, which are mediated by G proteins. The OR4N2 protein is one of these olfactory receptors and is specifically involved in the detection of certain odors.

== Structure ==

The OR4N2 gene is located on the [[chromosome 1]] (1q44) and is composed of a single coding exon. The protein encoded by this gene is a member of the G-protein coupled receptor 1 family and has 7 transmembrane domains, a characteristic structure of many neurotransmitter and hormone receptors.

== Clinical Significance ==

While the exact role of OR4N2 in disease is not fully understood, olfactory receptors in general have been implicated in various diseases, including [[neurodegenerative diseases]] like [[Parkinson's disease]] and [[Alzheimer's disease]], as well as certain types of [[cancer]].

== Research ==

Research into the OR4N2 gene and its associated protein is ongoing, with studies focusing on its role in odor detection and potential involvement in disease. Understanding the function of this and other olfactory receptors may provide insights into the mechanisms of smell and disease pathogenesis.

[[Category:Genes]]
[[Category:Human proteins]]
[[Category:G protein-coupled receptors]]
[[Category:Olfactory system]]
{{medicine-stub}}

OR4N2 - Revision history

Prab: CSV import

Prab: CSV import