Prab: CSV import

2024-12-30T20:34:58Z

CSV import

← Older revision		Revision as of 20:34, 30 December 2024
Line 1:		Line 1:
	'''OR2J1''' is a gene that encodes the olfactory receptor, family 2, subfamily J, member 1 protein in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

	~~[[File:OR2J1~~ gene ~~location on human chromosome 6.png~~\|~~thumb~~\|~~Location of~~ OR2J1 ~~gene on human~~ chromosome 6]]		{{Infobox gene
			\| name = OR2J1
			\| symbol = OR2J1
			\| HGNCid = 8261
			\| chromosome = 6
			\| arm = q
			\| band = 23
			}}

	~~== Function ==~~		'''OR2J1''' is a gene that encodes a member of the [[olfactory receptor]] family of proteins. These receptors are involved in the detection of odor molecules and are a part of the [[G protein-coupled receptor]] (GPCR) superfamily.

	The ~~protein encoded by the OR2J1 gene is an~~ olfactory receptor~~, expressed~~ in the [[olfactory epithelium]] ~~of the nose. Olfactory receptors interact with odorant molecules in the nose,~~ to ~~initiate a neuronal response that triggers~~ the ~~perception~~ of a smell. ~~The~~ olfactory receptor ~~proteins are members of~~ a ~~large family~~ of ~~G-protein-coupled receptors (GPCR) arising from single coding-exon genes~~.		==Function==
			Olfactory receptors, such as OR2J1, are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor proteins are located in the [[olfactory epithelium]] and are integral to the sense of [[smell]]. Each olfactory receptor gene is expressed in a small subset of olfactory sensory neurons, and each neuron expresses only one olfactory receptor gene.

	== ~~Clinical Significance~~ ==		==Structure==
			The OR2J1 protein, like other olfactory receptors, has a 7-transmembrane domain structure, which is a characteristic feature of many neurotransmitter and hormone receptors. This structure allows the receptor to interact with odorant molecules in the nasal cavity and initiate a neuronal response that is transmitted to the brain.

	~~Variations in the~~ OR2J1 gene ~~have been associated with differences~~ in the ~~perception of certain odors. For example~~, ~~a study published in the journal [[Chemical Senses]] found that individuals with a certain variant of~~ the OR2J1 gene ~~were more sensitive to the smell~~ of ~~certain chemicals~~.		==Genomics==
			The OR2J1 gene is located on chromosome 6q23. The olfactory receptor gene family is the largest in the human genome, and the genes are distributed across many chromosomes. The OR2J1 gene is part of a large cluster of olfactory receptor genes on chromosome 6.

	== ~~See Also~~ ==		==Clinical significance==
			Variations in olfactory receptor genes, including OR2J1, can affect an individual's sense of smell. However, specific clinical conditions directly associated with OR2J1 have not been extensively documented.

	* [[Olfactory ~~receptor~~]]		==Research==
			Research into olfactory receptors like OR2J1 is ongoing, with studies focusing on understanding the molecular mechanisms of odor detection and the role of these receptors in [[olfactory disorders]].

			==See also==
			* [[Olfactory system]]
	* [[G protein-coupled receptor]]		* [[G protein-coupled receptor]]
	* [[~~Olfactory epithelium~~]]		* [[Chromosome 6 (human)]]

	~~== References ==~~

	~~<references />~~		==References==
			{{Reflist}}

	~~{{G protein~~-~~coupled receptors}}~~		==External links==
	~~{{Olfactory receptors}}~~		* [https://www.ncbi.nlm.nih.gov/gene/OR2J1 OR2J1 Gene - NCBI]
	~~{{medicine~~-~~stub}}~~		* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2J1 OR2J1 Gene - GeneCards]

	[[Category:~~Genes]]~~		[[Category:Olfactory receptors]]
	~~[[Category:Human proteins~~]]
	[[Category:G protein-coupled receptors]]		[[Category:G protein-coupled receptors]]
	[[Category:~~Olfactory system~~]]		[[Category:Genes on human chromosome 6]]

Prab: CSV import

2024-03-10T06:38:31Z

CSV import

New page

'''OR2J1''' is a gene that encodes the olfactory receptor, family 2, subfamily J, member 1 protein in humans. The [[olfactory receptor]] proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome.

[[File:OR2J1 gene location on human chromosome 6.png|thumb|Location of OR2J1 gene on human chromosome 6]]

== Function ==

The protein encoded by the OR2J1 gene is an olfactory receptor, expressed in the [[olfactory epithelium]] of the nose. Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes.

== Clinical Significance ==

Variations in the OR2J1 gene have been associated with differences in the perception of certain odors. For example, a study published in the journal [[Chemical Senses]] found that individuals with a certain variant of the OR2J1 gene were more sensitive to the smell of certain chemicals.

== See Also ==

* [[Olfactory receptor]]
* [[G protein-coupled receptor]]
* [[Olfactory epithelium]]

== References ==

<references />

{{G protein-coupled receptors}}
{{Olfactory receptors}}
{{medicine-stub}}

[[Category:Genes]]
[[Category:Human proteins]]
[[Category:G protein-coupled receptors]]
[[Category:Olfactory system]]

OR2J1 - Revision history

Prab: CSV import

Prab: CSV import