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	'''OR2A4''' is a gene that encodes the olfactory receptor, family 2, subfamily A, member 4. It is part of the [[olfactory receptor]] family of genes which are the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

	== ~~Function~~ ==		{{Infobox gene
	The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. [[Olfactory receptor]]s share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.		\| name = OR2A4
			\| symbol = OR2A4
			\| HGNCid = 8181
			\| chromosome = 7
			\| arm = q
			\| band = 35
			}}

	~~== Gene ==~~		'''OR2A4''' is a gene that encodes a member of the olfactory receptor family of proteins. These receptors are involved in the detection of odor molecules and are part of the [[G protein-coupled receptor]] (GPCR) superfamily.
	~~The~~ OR2A4 gene ~~is located on chromosome 7, specifically at 7q31.31. It spans~~ a ~~length~~ of ~~0.948 kilobases and is encoded by a single exon~~. ~~The gene is expressed~~ in the ~~olfactory epithelium, a small patch~~ of ~~tissue inside~~ the ~~nose~~.

	== ~~Clinical Significance~~ ==		==Function==
	~~While~~ the ~~specific clinical significance~~ of ~~OR2A4 is not yet fully understood, olfactory receptors in general have been linked to various diseases~~. ~~For example, mutations in certain~~ olfactory ~~receptors have been associated with~~ a ~~decreased sense of smell~~, ~~known as [[anosmia]]~~. ~~Additionally, some research suggests that~~ olfactory ~~receptors may play a role in certain types of cancer, although more research~~ is ~~needed~~ in ~~this area~~.		Olfactory receptors, such as OR2A4, are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor proteins are characterized by a 7-transmembrane domain structure, which is also shared by many neurotransmitter and hormone receptors. The olfactory receptor gene family is the largest in the human genome.

	~~[[File:~~OR2A4 gene ~~location on human chromosome 7~~.~~png\|thumb\|right\|300px\|Location~~ of ~~OR2A4~~ gene ~~on human chromosome 7~~.]]		==Gene Family==
			The OR2A4 gene is part of a large family of olfactory receptor genes. These genes are distributed throughout the genome and are responsible for the vast array of smells that humans can detect. The olfactory receptor gene family is highly diverse, allowing for the detection of a wide range of odorant molecules.

	== See Also ==		==Location==
			The OR2A4 gene is located on the long arm (q) of [[chromosome 7]], specifically at band 35. This location is part of a cluster of olfactory receptor genes.

			==Clinical Significance==
			While the primary function of OR2A4 is related to olfaction, variations in olfactory receptor genes can sometimes be associated with differences in odor perception among individuals. However, specific clinical conditions directly linked to OR2A4 have not been extensively documented.

			==Research==
			Research into olfactory receptors like OR2A4 continues to provide insights into the mechanisms of smell and the genetic basis of olfactory perception. Studies often focus on the expression patterns of these receptors and their role in the olfactory system.

			==See Also==
	* [[Olfactory receptor]]		* [[Olfactory receptor]]
	* [[Anosmia]]
	* [[G protein-coupled receptor]]		* [[G protein-coupled receptor]]
			* [[Chromosome 7]]

	== References ==		==References==
	~~<references />~~		{{Reflist}}

	[[Category:Genes]]		==External Links==
	[[Category:Olfactory ~~system~~]]		* [https://www.ncbi.nlm.nih.gov/gene/OR2A4 OR2A4 Gene - NCBI]
			* [https://www.genecards.org/cgi-bin/carddisp.pl?gene=OR2A4 OR2A4 Gene - GeneCards]

			[[Category:Genes on human chromosome 7]]
			[[Category:Olfactory receptors]]
	[[Category:G protein-coupled receptors]]		[[Category:G protein-coupled receptors]]

	~~{{medicine-stub}}~~

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'''OR2A4''' is a gene that encodes the olfactory receptor, family 2, subfamily A, member 4. It is part of the [[olfactory receptor]] family of genes which are the largest gene family in the genome. The olfactory receptors interact with odorant molecules in the nose to initiate a neuronal response that triggers the perception of a smell.

== Function ==
The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. [[Olfactory receptor]]s share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

== Gene ==
The OR2A4 gene is located on chromosome 7, specifically at 7q31.31. It spans a length of 0.948 kilobases and is encoded by a single exon. The gene is expressed in the olfactory epithelium, a small patch of tissue inside the nose.

== Clinical Significance ==
While the specific clinical significance of OR2A4 is not yet fully understood, olfactory receptors in general have been linked to various diseases. For example, mutations in certain olfactory receptors have been associated with a decreased sense of smell, known as [[anosmia]]. Additionally, some research suggests that olfactory receptors may play a role in certain types of cancer, although more research is needed in this area.

[[File:OR2A4 gene location on human chromosome 7.png|thumb|right|300px|Location of OR2A4 gene on human chromosome 7.]]

== See Also ==
* [[Olfactory receptor]]
* [[Anosmia]]
* [[G protein-coupled receptor]]

== References ==
<references />

[[Category:Genes]]
[[Category:Olfactory system]]
[[Category:G protein-coupled receptors]]

{{medicine-stub}}

OR2A4 - Revision history

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