Prab: CSV import

2025-02-13T04:04:59Z

CSV import

← Older revision		Revision as of 04:04, 13 February 2025
Line 1:		Line 1:
	'''O-2172''' is a [[synthetic cannabinoid]] that is used in scientific research. It is a selective [[agonist]] for the [[peripheral cannabinoid receptor]] CB2, with much lower affinity for the central CB1 receptor.		== Overview ==

	~~==Chemistry==~~		[[File:O-2172_Structure.svg\|thumb\|right\|Chemical structure of O-2172]]
	O-~~2172 is part of a group of synthetic cannabinoids known as [[naphthoylindoles]]. These compounds are characterized by a naphthoyl group attached to an indole core~~. ~~The specific~~ structure of O-2172 ~~consists of a naphthoyl group attached at the 3-position of the indole ring, with a secondary amide linkage to a cyclohexylmethyl tail.~~

	~~==Pharmacology==~~		'''O-2172''' is a synthetic cannabinoid that has been studied for its potential therapeutic effects. It is a derivative of the naturally occurring compound [[cannabidiol]] (CBD) and is known for its interaction with the [[endocannabinoid system]]. O-2172 has been the subject of research due to its potential to modulate various physiological processes without the psychoactive effects associated with [[tetrahydrocannabinol]] (THC).
	O-2172 ~~acts as~~ a ~~selective agonist~~ for the ~~CB2 receptor, with a~~ [[Ki]] ~~value of 1.6 nM. It has 60 times lower affinity~~ for the ~~CB1 receptor, with a Ki value of 96 nM~~. ~~This selectivity makes~~ O-2172 ~~useful for studying~~ the ~~role~~ of ~~CB2 receptors in the body,~~ without the psychoactive effects associated with ~~activation of CB1 receptors~~.

	==~~Uses in Research~~==		== Chemical Properties ==
	Due to its selectivity for CB2 receptors, O-2172 has been used in research to study the role of these receptors in various physiological processes. This includes research into pain, inflammation, and immune system function. The compound has also been used to investigate the potential therapeutic benefits of CB2 receptor activation, such as in the treatment of [[chronic pain]] or [[autoimmune diseases]].

	==~~Legal Status~~==		O-2172 is characterized by its unique chemical structure, which is depicted in the adjacent image. The compound is a synthetic analog of CBD, designed to enhance certain pharmacological properties while minimizing psychoactivity. The structure of O-2172 allows it to interact with cannabinoid receptors in the body, particularly [[CB1 receptor\|CB1]] and [[CB2 receptor\|CB2]] receptors, although its affinity for these receptors is different from that of THC.
	As a ~~synthetic cannabinoid~~, the ~~legal status~~ of O-2172 ~~varies by country~~. ~~In some jurisdictions~~, it may be ~~considered~~ a ~~controlled substance~~. ~~Researchers wishing to work~~ with O-2172 ~~should consult local regulations~~ to ~~ensure compliance~~.
			== Pharmacology ==

			O-2172 acts primarily on the endocannabinoid system, which plays a crucial role in maintaining [[homeostasis]] within the body. Unlike THC, O-2172 does not produce significant psychoactive effects, making it a candidate for therapeutic applications where such effects are undesirable. The compound has been shown to have anti-inflammatory, analgesic, and neuroprotective properties in preclinical studies.

			=== Mechanism of Action ===

			The mechanism of action of O-2172 involves modulation of the endocannabinoid system. It is believed to act as a partial agonist at CB1 and CB2 receptors, although its exact binding affinity and efficacy at these receptors are subjects of ongoing research. Additionally, O-2172 may influence the activity of other neurotransmitter systems, contributing to its therapeutic potential.

			== Potential Therapeutic Uses ==

			Research into O-2172 has suggested several potential therapeutic applications, including:

			* '''Pain Management''': Due to its analgesic properties, O-2172 may be useful in treating chronic pain conditions without the risk of addiction associated with opioid medications.
			* '''Inflammatory Disorders''': The anti-inflammatory effects of O-2172 make it a candidate for treating conditions such as [[arthritis]] and [[inflammatory bowel disease]].
			* '''Neuroprotection''': O-2172 has shown promise in protecting against neurodegenerative diseases like [[Alzheimer's disease]] and [[Parkinson's disease]].

			== Safety and Side Effects ==

			As with any pharmacological agent, the safety profile of O-2172 is an important consideration. Preclinical studies have indicated that O-2172 is well-tolerated at therapeutic doses, with a low incidence of adverse effects. However, further research is needed to fully understand its long-term safety and potential side effects in humans.

			== Related Pages ==

	~~==See Also==~~
	* [[Cannabinoid receptor]]		* [[Cannabinoid receptor]]
	* [[~~Synthetic cannabinoids~~]]		* [[Endocannabinoid system]]
	* [[~~Naphthoylindoles~~]]		* [[Cannabidiol]]
			* [[Tetrahydrocannabinol]]

	[[Category:Synthetic cannabinoids]]		[[Category:Synthetic cannabinoids]]
	~~[[Category:Research chemicals]]~~
	~~[[Category:CB2 agonists]]~~
	~~{{pharmacology-stub}}~~
	~~{{chemistry-stub}}~~

Prab: CSV import

2024-02-29T03:54:28Z

CSV import

New page

'''O-2172''' is a [[synthetic cannabinoid]] that is used in scientific research. It is a selective [[agonist]] for the [[peripheral cannabinoid receptor]] CB2, with much lower affinity for the central CB1 receptor.

==Chemistry==
O-2172 is part of a group of synthetic cannabinoids known as [[naphthoylindoles]]. These compounds are characterized by a naphthoyl group attached to an indole core. The specific structure of O-2172 consists of a naphthoyl group attached at the 3-position of the indole ring, with a secondary amide linkage to a cyclohexylmethyl tail.

==Pharmacology==
O-2172 acts as a selective agonist for the CB2 receptor, with a [[Ki]] value of 1.6 nM. It has 60 times lower affinity for the CB1 receptor, with a Ki value of 96 nM. This selectivity makes O-2172 useful for studying the role of CB2 receptors in the body, without the psychoactive effects associated with activation of CB1 receptors.

==Uses in Research==
Due to its selectivity for CB2 receptors, O-2172 has been used in research to study the role of these receptors in various physiological processes. This includes research into pain, inflammation, and immune system function. The compound has also been used to investigate the potential therapeutic benefits of CB2 receptor activation, such as in the treatment of [[chronic pain]] or [[autoimmune diseases]].

==Legal Status==
As a synthetic cannabinoid, the legal status of O-2172 varies by country. In some jurisdictions, it may be considered a controlled substance. Researchers wishing to work with O-2172 should consult local regulations to ensure compliance.

==See Also==
* [[Cannabinoid receptor]]
* [[Synthetic cannabinoids]]
* [[Naphthoylindoles]]

[[Category:Synthetic cannabinoids]]
[[Category:Research chemicals]]
[[Category:CB2 agonists]]
{{pharmacology-stub}}
{{chemistry-stub}}

O-2172 - Revision history

Prab: CSV import

Prab: CSV import