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			File:NDPK_structure_.jpg\|Structure of Nucleoside-diphosphate kinase
			File:Ping-Pong_Mechanism.jpg\|Ping-Pong Mechanism of Nucleoside-diphosphate kinase
			File:NDPK_ppGpp_Cycle.png\|Nucleoside-diphosphate kinase ppGpp Cycle
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'''Nucleoside-diphosphate kinase''' (NDPK) is an [[enzyme]] that plays a crucial role in the synthesis of [[nucleoside triphosphates]] (NTPs) other than [[adenosine triphosphate]] (ATP). It is involved in numerous cellular processes, including [[DNA replication]], [[RNA transcription]], and [[signal transduction]], making it essential for cell growth and maintenance.

== Function ==
NDPK functions by transferring the γ-phosphate group from a [[nucleoside triphosphate]] donor, such as ATP, to a [[nucleoside diphosphate]] acceptor, such as [[guanosine diphosphate]] (GDP), thus generating the corresponding nucleoside triphosphate, in this case, [[guanosine triphosphate]] (GTP). This reaction is critical for maintaining the cellular balance of NTPs, which are required for various biochemical processes.

== Structure ==
The structure of NDPK is highly conserved across different species. It typically functions as a hexamer composed of identical or closely related subunits. Each subunit contains a nucleotide binding domain and a catalytic domain, which are necessary for the enzyme's activity.

== Isoforms ==
In humans, several isoforms of NDPK have been identified, designated as NDPK-A, NDPK-B, and NDPK-C, among others. These isoforms are encoded by different genes and exhibit distinct tissue distributions and functions. For example, NDPK-A is ubiquitously expressed, while NDPK-B is more specific to certain tissues.

== Clinical Significance ==
Alterations in the expression or activity of NDPK have been linked to various diseases, including [[cancer]], where it may function as a metastasis suppressor or promoter, depending on the context. Additionally, mutations in the genes encoding NDPK isoforms have been associated with certain genetic disorders.

== Research ==
Ongoing research aims to further elucidate the roles of NDPK in cellular processes and disease. Understanding the mechanisms by which NDPK functions could lead to the development of novel therapeutic strategies for treating diseases associated with its dysregulation.

[[Category:Enzymes]]
[[Category:Cell biology]]

{{biochemistry-stub}}

Nucleoside-diphosphate kinase - Revision history

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