https://wikimd.com/index.php?action=history&feed=atom&title=NormethadoneNormethadone - Revision history2026-04-22T22:45:30ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.com/index.php?title=Normethadone&diff=5808622&oldid=prevPrab: CSV import2024-05-22T17:23:37Z<p>CSV import</p>
<p><b>New page</b></p><div>[[File:Normethadone.png|thumb|Normethadone.png]] '''Normethadone''' is a synthetic opioid analgesic and antitussive agent. It is chemically related to [[methadone]] and is used in the management of moderate to severe pain and as a cough suppressant.<br />
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==Chemical Structure and Properties==<br />
Normethadone, also known by its chemical name desmethylmethadone, is a derivative of methadone. Its chemical formula is C20H25NO, and it has a molecular weight of 295.42 g/mol. The structure of normethadone includes a phenyl ring, a cyclohexane ring, and a tertiary amine group.<br />
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==Pharmacology==<br />
Normethadone acts on the [[central nervous system]] (CNS) by binding to the [[mu-opioid receptor]]s, which are responsible for its analgesic and antitussive effects. It has a similar mechanism of action to methadone but is less potent. The drug is metabolized in the [[liver]] and excreted primarily through the [[kidneys]].<br />
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==Medical Uses==<br />
Normethadone is used for:<br />
* Management of moderate to severe [[pain]]<br />
* Suppression of [[cough]] in certain medical conditions<br />
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==Side Effects==<br />
Common side effects of normethadone include:<br />
* [[Nausea]]<br />
* [[Vomiting]]<br />
* [[Drowsiness]]<br />
* [[Dizziness]]<br />
* [[Constipation]]<br />
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Severe side effects may include:<br />
* [[Respiratory depression]]<br />
* [[Hypotension]]<br />
* [[Bradycardia]]<br />
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==Regulation and Legal Status==<br />
Normethadone is classified as a controlled substance in many countries due to its potential for abuse and dependence. It is regulated under various national and international drug control laws.<br />
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==History==<br />
Normethadone was developed as an alternative to methadone, with the aim of providing effective pain relief and cough suppression with potentially fewer side effects. It has been used in clinical practice since the mid-20th century.<br />
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==See Also==<br />
* [[Methadone]]<br />
* [[Opioid]]<br />
* [[Analgesic]]<br />
* [[Antitussive]]<br />
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==References==<br />
{{Reflist}}<br />
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==External Links==<br />
{{Commons category|Normethadone}}<br />
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[[Category:Opioids]]<br />
[[Category:Analgesics]]<br />
[[Category:Antitussives]]<br />
[[Category:Synthetic opioids]]<br />
[[Category:Controlled substances]]<br />
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