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<p><b>New page</b></p><div>[[File:Norbormide.png|thumb|{{PAGENAME}}]]<br>'''Norbormide''' is a [[rodenticide]] that is specifically toxic to [[rats]]. It was discovered in the 1960s by scientists at the [[Shell Development Company]] in California. Norbormide is unique among rodenticides due to its selective toxicity towards rats, particularly the [[Rattus norvegicus|R. norvegicus]] species, while being relatively harmless to other animals.<br />
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==Chemistry==<br />
Norbormide is a [[pharmacologically]] active [[N-acyl]] derivative of a [[bicyclic]] [[amine]]. Its chemical name is N-3,5-dinitrophenyl norbornanedicarboximide. The compound has a complex mode of action that is not fully understood, but it is known to cause vasoconstriction in rats, leading to their death.<br />
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==Toxicity==<br />
The toxicity of norbormide is highly specific to rats. It is thought that this selectivity is due to a combination of factors, including the rat's specific metabolic pathways and the presence of a specific binding site in the rat's [[vascular smooth muscle]] cells. The lethal dose for rats is around 10 mg/kg, while the lethal dose for other animals is significantly higher.<br />
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==Use and Regulation==<br />
Norbormide has been used as a rodenticide in various countries around the world. However, its use has been limited due to its relatively slow action and the fact that rats often avoid eating it. In the [[European Union]], norbormide is not approved for use as a rodenticide due to concerns about its environmental impact.<br />
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==Research==<br />
Research into norbormide is ongoing, with scientists seeking to understand its unique selectivity and to potentially develop new, more effective rodenticides based on its structure and mode of action.<br />
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==See Also==<br />
* [[Rodenticide]]<br />
* [[Rattus norvegicus]]<br />
* [[Shell Development Company]]<br />
* [[Vascular smooth muscle]]<br />
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[[Category:Rodenticides]]<br />
[[Category:Pharmacology]]<br />
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