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	~~'''~~Nonsteroidal estrogen''' is a type of [[estrogen]] that is not derived from steroids. It is a synthetic form of estrogen that is often used in [[hormone replacement therapy]] and for the treatment of [[menopausal]] symptoms.		{{DISPLAYTITLE:Nonsteroidal Estrogen}}

	== ~~Overview~~ ==		== Nonsteroidal Estrogen ==

	Nonsteroidal estrogens are a class of ~~drugs~~ that mimic the ~~effects~~ of natural estrogen in the body. ~~They are often used~~ in ~~medical treatments~~ to ~~replace or supplement the body's~~ natural ~~estrogen levels~~. ~~This can be beneficial in treating a variety~~ of ~~conditions, such as~~ [[~~osteoporosis~~]], ~~[[breast cancer]]~~, ~~and~~ menopausal symptoms.		[[File:Diethylstilbestrol.svg\|thumb\|right\|Chemical structure of Diethylstilbestrol]]

			Nonsteroidal estrogens are a class of synthetic compounds that mimic the biological activity of the natural hormone [[estrogen]]. Unlike steroidal estrogens, nonsteroidal estrogens do not have the steroid structure but can still bind to estrogen receptors and exert estrogenic effects in the body.

			== History ==

			The development of nonsteroidal estrogens began in the early 20th century as researchers sought to create synthetic alternatives to natural estrogens. One of the most well-known nonsteroidal estrogens is [[Diethylstilbestrol]] (DES), which was first synthesized in 1938. DES was widely used in the mid-20th century for various medical conditions, including as a treatment for menopausal symptoms and as a growth promoter in livestock.

	== Mechanism of Action ==		== Mechanism of Action ==

	Nonsteroidal estrogens ~~work~~ by binding to [[estrogen receptors]] in ~~the body~~. These receptors are ~~found in various tissues, including~~ the ~~[[breast]]~~, ~~[[uterus]]~~, ~~and [[bone]]~~. ~~When~~ nonsteroidal estrogens ~~bind~~ to these receptors~~, they~~ can ~~stimulate~~ the ~~same biological~~ responses ~~as natural estrogen~~.		Nonsteroidal estrogens function by binding to [[estrogen receptors]] in target tissues. These receptors are part of the nuclear receptor family and, upon activation by an estrogenic compound, can regulate the expression of specific genes. The binding of nonsteroidal estrogens to these receptors can mimic the effects of natural estrogens, leading to similar physiological responses.

	== Uses ==		== Uses ==

	Nonsteroidal estrogens ~~are~~ used in ~~a variety of~~ medical ~~treatments. They are often used in hormone replacement therapy for women who are experiencing menopausal symptoms. This can help to alleviate symptoms such as [[hot flashes]], [[night sweats]]~~, ~~and [[vaginal dryness]].~~		Nonsteroidal estrogens have been used in various medical applications, including:

	~~In addition,~~ nonsteroidal estrogens ~~are also~~ used in ~~the treatment of osteoporosis~~. ~~They can help to prevent bone loss and increase bone density~~, ~~reducing the risk of fractures~~.		* '''Hormone Replacement Therapy (HRT):''' Nonsteroidal estrogens have been used in HRT to alleviate symptoms of [[menopause]] such as hot flashes and vaginal dryness.
			* '''Contraception:''' Some nonsteroidal estrogens have been used in combination with progestins in oral contraceptives.
			* '''Cancer Treatment:''' Certain nonsteroidal estrogens have been investigated for their potential use in treating hormone-sensitive cancers, such as [[breast cancer]].

	== ~~Side Effects~~ ==		== Risks and Controversies ==

	~~Like all medications,~~ nonsteroidal estrogens ~~can have side effects. These can include [[nausea]], [[vomiting]], [[bloating]]~~, ~~[[breast tenderness]]~~, ~~and [[headaches]]~~. In ~~some cases~~, ~~nonsteroidal estrogens can also increase the~~ risk of ~~certain types~~ of cancer~~, such~~ as ~~breast cancer~~ and ~~uterine cancer~~.		The use of nonsteroidal estrogens, particularly DES, has been associated with significant health risks. In the 1970s, it was discovered that daughters of women who took DES during pregnancy had an increased risk of developing a rare form of vaginal cancer known as clear cell adenocarcinoma. This led to a reevaluation of the safety of nonsteroidal estrogens and a decline in their use.

	== ~~See Also~~ ==		== Related Pages ==

	* [[Estrogen]]		* [[Estrogen]]
	* [[~~Hormone replacement therapy~~]]		* [[Diethylstilbestrol]]
	* [[~~Menopause]]~~		* [[Hormone Replacement Therapy]]
	* [[Osteoporosis]]		* [[Breast Cancer]]
	* [[Breast ~~cancer~~]]

	~~== References ==~~

	~~{{reflist}}~~

			[[Category:Estrogens]]
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	~~[[Category:Endocrinology]]~~
	~~[[Category:Women's health]]~~

	~~{{pharmacology-stub}}~~

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2024-03-08T18:02:36Z

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'''Nonsteroidal estrogen''' is a type of [[estrogen]] that is not derived from steroids. It is a synthetic form of estrogen that is often used in [[hormone replacement therapy]] and for the treatment of [[menopausal]] symptoms.

== Overview ==

Nonsteroidal estrogens are a class of drugs that mimic the effects of natural estrogen in the body. They are often used in medical treatments to replace or supplement the body's natural estrogen levels. This can be beneficial in treating a variety of conditions, such as [[osteoporosis]], [[breast cancer]], and menopausal symptoms.

== Mechanism of Action ==

Nonsteroidal estrogens work by binding to [[estrogen receptors]] in the body. These receptors are found in various tissues, including the [[breast]], [[uterus]], and [[bone]]. When nonsteroidal estrogens bind to these receptors, they can stimulate the same biological responses as natural estrogen.

== Uses ==

Nonsteroidal estrogens are used in a variety of medical treatments. They are often used in hormone replacement therapy for women who are experiencing menopausal symptoms. This can help to alleviate symptoms such as [[hot flashes]], [[night sweats]], and [[vaginal dryness]].

In addition, nonsteroidal estrogens are also used in the treatment of osteoporosis. They can help to prevent bone loss and increase bone density, reducing the risk of fractures.

== Side Effects ==

Like all medications, nonsteroidal estrogens can have side effects. These can include [[nausea]], [[vomiting]], [[bloating]], [[breast tenderness]], and [[headaches]]. In some cases, nonsteroidal estrogens can also increase the risk of certain types of cancer, such as breast cancer and uterine cancer.

== See Also ==

* [[Estrogen]]
* [[Hormone replacement therapy]]
* [[Menopause]]
* [[Osteoporosis]]
* [[Breast cancer]]

== References ==

{{reflist}}

[[Category:Pharmacology]]
[[Category:Endocrinology]]
[[Category:Women's health]]

{{pharmacology-stub}}

Nonsteroidal estrogen - Revision history

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