Non-ossifying fibroma - Revision history

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	{{Short description\|A benign bone tumor}}		{{Short description\|A benign bone tumor}}

	'''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons.		'''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons.
	==Pathophysiology==		==Pathophysiology==

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			{{SI}}
			{{Infobox medical condition
			\| name = Non-ossifying fibroma
			\| image = [[File:NOF_1.jpg]]
			\| caption = X-ray of a non-ossifying fibroma in the distal femur
			\| field = [[Orthopedics]]
			\| synonyms = Metaphyseal fibrous defect, fibrous cortical defect
			\| symptoms = Usually asymptomatic, may cause pain or fracture if large
			\| complications = Pathological fracture
			\| onset = Typically in children and adolescents
			\| duration = Often resolves spontaneously
			\| causes = Unknown, possibly developmental
			\| risks = None known
			\| diagnosis = [[X-ray]], [[CT scan]], [[MRI]]
			\| differential = [[Fibrous dysplasia]], [[Osteosarcoma]], [[Chondromyxoid fibroma]]
			\| treatment = Observation, surgical curettage if symptomatic
			\| prognosis = Excellent, often resolves without treatment
			\| frequency = Common in children, especially males
			}}
	{{Short description\|A benign bone tumor}}		{{Short description\|A benign bone tumor}}
	~~{{Use dmy dates\|date=October 2023}}~~

	'''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons.		'''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons.

	==Pathophysiology==		==Pathophysiology==
	Non-ossifying fibromas are composed of fibrous tissue and are considered a type of [[fibrous cortical defect]]. They are characterized by a proliferation of spindle-shaped fibroblasts and histiocytes, often with scattered multinucleated giant cells. The lesion is typically well-circumscribed and located in the [[cortex]] of the bone.		Non-ossifying fibromas are composed of fibrous tissue and are considered a type of [[fibrous cortical defect]]. They are characterized by a proliferation of spindle-shaped fibroblasts and histiocytes, often with scattered multinucleated giant cells. The lesion is typically well-circumscribed and located in the [[cortex]] of the bone.

	==Clinical Presentation==		==Clinical Presentation==
	Most non-ossifying fibromas are asymptomatic and are found incidentally. However, larger lesions may cause [[pain]] or [[pathological fracture]]s, especially if they weaken the structural integrity of the bone.		Most non-ossifying fibromas are asymptomatic and are found incidentally. However, larger lesions may cause [[pain]] or [[pathological fracture]]s, especially if they weaken the structural integrity of the bone.

	==Diagnosis==		==Diagnosis==
	Diagnosis is primarily made through imaging studies. On [[X-ray]], non-ossifying fibromas appear as well-defined, eccentric, lytic lesions with a sclerotic margin. They are often located in the metaphysis of long bones such as the [[femur]] or [[tibia]].		Diagnosis is primarily made through imaging studies. On [[X-ray]], non-ossifying fibromas appear as well-defined, eccentric, lytic lesions with a sclerotic margin. They are often located in the metaphysis of long bones such as the [[femur]] or [[tibia]].

	~~[[File:NOF_1.jpg\|Non-ossifying fibroma\|thumb\|right]]~~

	Advanced imaging techniques such as [[CT scan]] or [[MRI]] can be used to further characterize the lesion. On CT, a mature non-ossifying fibroma may show a well-defined, cortically based lesion with a sclerotic rim.		Advanced imaging techniques such as [[CT scan]] or [[MRI]] can be used to further characterize the lesion. On CT, a mature non-ossifying fibroma may show a well-defined, cortically based lesion with a sclerotic rim.
			[[File:MaturenonossifyingfibromaCT.PNG\|Mature non-ossifying fibroma CT\|left\|thumb]]
	[[File:MaturenonossifyingfibromaCT.PNG\|Mature non-ossifying fibroma CT\|thumb~~\|left~~]]

	==Treatment==		==Treatment==
	In most cases, non-ossifying fibromas do not require treatment and are monitored with periodic imaging. If the lesion is large or symptomatic, surgical intervention may be necessary. This can include curettage and bone grafting to stabilize the bone and prevent fracture.		In most cases, non-ossifying fibromas do not require treatment and are monitored with periodic imaging. If the lesion is large or symptomatic, surgical intervention may be necessary. This can include curettage and bone grafting to stabilize the bone and prevent fracture.

	==Prognosis==		==Prognosis==
	The prognosis for non-ossifying fibroma is excellent. These lesions often spontaneously regress as the child grows, and they rarely cause long-term complications. Malignant transformation is extremely rare.		The prognosis for non-ossifying fibroma is excellent. These lesions often spontaneously regress as the child grows, and they rarely cause long-term complications. Malignant transformation is extremely rare.
			==See also==
	==~~Related pages~~==
	* [[Bone tumor]]		* [[Bone tumor]]
	* [[Fibrous dysplasia]]		* [[Fibrous dysplasia]]
	* [[Osteochondroma]]		* [[Osteochondroma]]

	[[Category:Benign neoplasms]]		[[Category:Benign neoplasms]]
	[[Category:Bone disorders]]		[[Category:Bone disorders]]
	[[Category:Pediatrics]]		[[Category:Pediatrics]]

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	~~'''Non-ossifying fibroma''' is a benign, non-cancerous tumor that usually occurs in the long bones of the legs in children and adolescents. It is the most common~~ benign bone tumor ~~in children. Non-ossifying fibromas are usually asymptomatic and are often discovered incidentally on X-ray.~~		{{Short description\|A benign bone tumor}}
			{{Use dmy dates\|date=October 2023}}

	~~== Symptoms ==~~		'''Non-ossifying fibroma''' (NOF) is a benign [[bone tumor]] that typically occurs in the [[metaphysis]] of long bones in children and adolescents. It is one of the most common benign bone lesions and is often discovered incidentally on [[X-ray]]s taken for other reasons.
	Non-ossifying ~~fibromas are usually asymptomatic, meaning they do not cause any symptoms. However,~~ in ~~some cases, they may cause pain or swelling~~ in the ~~affected~~ bone~~. In rare cases, they may cause a pathological fracture, which~~ is ~~a break in a bone caused by a disease or condition~~.

	== ~~Causes~~ ==		==Pathophysiology==
	~~The exact cause of non~~-ossifying fibromas ~~is unknown~~. They are ~~thought to be related to the normal growth~~ and ~~development of bones~~. ~~Non~~-~~ossifying fibromas are more common in boys than in girls,~~ and ~~they usually occur~~ in the ~~first two decades~~ of ~~life~~.		Non-ossifying fibromas are composed of fibrous tissue and are considered a type of [[fibrous cortical defect]]. They are characterized by a proliferation of spindle-shaped fibroblasts and histiocytes, often with scattered multinucleated giant cells. The lesion is typically well-circumscribed and located in the [[cortex]] of the bone.

	== ~~Diagnosis~~ ==		==Clinical Presentation==
	~~Non~~-ossifying fibromas are ~~usually discovered~~ incidentally ~~on X-ray~~. ~~They appear as a well-defined~~, ~~lytic lesion with a thin rim~~ of ~~sclerotic~~ bone~~. In some cases, a CT scan or MRI may be used to further evaluate the lesion~~.		Most non-ossifying fibromas are asymptomatic and are found incidentally. However, larger lesions may cause [[pain]] or [[pathological fracture]]s, especially if they weaken the structural integrity of the bone.

	== ~~Treatment~~ ==		==Diagnosis==
	~~Most~~ non-ossifying fibromas ~~do not require treatment~~, ~~as they usually stop growing and begin to heal on their own once~~ a ~~child has finished growing~~. ~~In cases where~~ the ~~fibroma is causing pain or has caused a pathological fracture, treatment may include surgery to remove~~ the ~~fibroma and/~~or ~~stabilize the bone~~.		Diagnosis is primarily made through imaging studies. On [[X-ray]], non-ossifying fibromas appear as well-defined, eccentric, lytic lesions with a sclerotic margin. They are often located in the metaphysis of long bones such as the [[femur]] or [[tibia]].

	== ~~See also~~ ==		[[File:NOF_1.jpg\|Non-ossifying fibroma\|thumb\|right]]

			Advanced imaging techniques such as [[CT scan]] or [[MRI]] can be used to further characterize the lesion. On CT, a mature non-ossifying fibroma may show a well-defined, cortically based lesion with a sclerotic rim.

			[[File:MaturenonossifyingfibromaCT.PNG\|Mature non-ossifying fibroma CT\|thumb\|left]]

			==Treatment==
			In most cases, non-ossifying fibromas do not require treatment and are monitored with periodic imaging. If the lesion is large or symptomatic, surgical intervention may be necessary. This can include curettage and bone grafting to stabilize the bone and prevent fracture.

			==Prognosis==
			The prognosis for non-ossifying fibroma is excellent. These lesions often spontaneously regress as the child grows, and they rarely cause long-term complications. Malignant transformation is extremely rare.

			==Related pages==
	* [[Bone tumor]]		* [[Bone tumor]]
	* [[~~Fibroma~~]]		* [[Fibrous dysplasia]]
	* [[~~Pathological fracture~~]]		* [[Osteochondroma]]

	[[Category:~~Medical conditions~~]]		[[Category:Benign neoplasms]]
	[[Category:Bone ~~diseases~~]]		[[Category:Bone disorders]]
	[[Category:Pediatrics]]		[[Category:Pediatrics]]

	~~{{stub}}~~

	~~== Non-ossifying fibroma ==~~
	~~<gallery>~~
	~~File:NOF_1.jpg~~
	~~File:MaturenonossifyingfibromaCT.PNG~~
	~~</gallery>~~
	~~== Non-ossifying fibroma ==~~
	~~<gallery>~~
	~~File:NOF_1.jpg\|Non-ossifying fibroma~~
	~~File:MaturenonossifyingfibromaCT.PNG\|Mature non-ossifying fibroma CT~~
	~~</gallery>~~

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	File:NOF_1.jpg		File:NOF_1.jpg
	File:MaturenonossifyingfibromaCT.PNG		File:MaturenonossifyingfibromaCT.PNG
			</gallery>
			== Non-ossifying fibroma ==
			<gallery>
			File:NOF_1.jpg\|Non-ossifying fibroma
			File:MaturenonossifyingfibromaCT.PNG\|Mature non-ossifying fibroma CT
	</gallery>		</gallery>

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	{{stub}}		{{stub}}

			== Non-ossifying fibroma ==
			<gallery>
			File:NOF_1.jpg
			File:MaturenonossifyingfibromaCT.PNG
			</gallery>

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New page

'''Non-ossifying fibroma''' is a benign, non-cancerous tumor that usually occurs in the long bones of the legs in children and adolescents. It is the most common benign bone tumor in children. Non-ossifying fibromas are usually asymptomatic and are often discovered incidentally on X-ray.

== Symptoms ==
Non-ossifying fibromas are usually asymptomatic, meaning they do not cause any symptoms. However, in some cases, they may cause pain or swelling in the affected bone. In rare cases, they may cause a pathological fracture, which is a break in a bone caused by a disease or condition.

== Causes ==
The exact cause of non-ossifying fibromas is unknown. They are thought to be related to the normal growth and development of bones. Non-ossifying fibromas are more common in boys than in girls, and they usually occur in the first two decades of life.

== Diagnosis ==
Non-ossifying fibromas are usually discovered incidentally on X-ray. They appear as a well-defined, lytic lesion with a thin rim of sclerotic bone. In some cases, a CT scan or MRI may be used to further evaluate the lesion.

== Treatment ==
Most non-ossifying fibromas do not require treatment, as they usually stop growing and begin to heal on their own once a child has finished growing. In cases where the fibroma is causing pain or has caused a pathological fracture, treatment may include surgery to remove the fibroma and/or stabilize the bone.

== See also ==
* [[Bone tumor]]
* [[Fibroma]]
* [[Pathological fracture]]

[[Category:Medical conditions]]
[[Category:Bone diseases]]
[[Category:Pediatrics]]

{{stub}}