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	<id>https://wikimd.org/index.php?action=history&amp;feed=atom&amp;title=No-observed-adverse-effect_level</id>
	<title>No-observed-adverse-effect level - Revision history</title>
	<link rel="self" type="application/atom+xml" href="https://wikimd.org/index.php?action=history&amp;feed=atom&amp;title=No-observed-adverse-effect_level"/>
	<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;action=history"/>
	<updated>2026-04-25T17:41:51Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
	<generator>MediaWiki 1.44.2</generator>
	<entry>
		<id>https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=6525285&amp;oldid=prev</id>
		<title>Prab at 13:00, 18 March 2025</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=6525285&amp;oldid=prev"/>
		<updated>2025-03-18T13:00:26Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 13:00, 18 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=6514776&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=6514776&amp;oldid=prev"/>
		<updated>2025-03-17T20:13:32Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 20:13, 17 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=6275853&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=6275853&amp;oldid=prev"/>
		<updated>2025-02-11T04:29:24Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 04:29, 11 February 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=5274020&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.org/index.php?title=No-observed-adverse-effect_level&amp;diff=5274020&amp;oldid=prev"/>
		<updated>2024-02-24T21:50:57Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;No-observed-adverse-effect level&amp;#039;&amp;#039;&amp;#039; (NOAEL) is a measure used in [[toxicology]] studies to denote the level of exposure of an organism, such as a human or animal, to a substance at which there are no observable adverse effects. It is usually derived from [[laboratory]] tests on animals and is used to establish safe levels for human exposure to the same substance.&lt;br /&gt;
&lt;br /&gt;
==Definition==&lt;br /&gt;
The NOAEL is the highest experimental point that is without an adverse effect. It is used to study the effects of [[chemical]]s on health. The NOAEL is a part of the process of deriving acceptable daily intakes or tolerable daily intakes.&lt;br /&gt;
&lt;br /&gt;
==Use in Risk Assessment==&lt;br /&gt;
In [[risk assessment]], the NOAEL is used to determine the [[Reference Dose]] (RfD) or the [[Tolerable daily intake]] (TDI). The RfD or TDI is calculated by dividing the NOAEL by a safety factor. The safety factor is used to account for uncertainties in the data.&lt;br /&gt;
&lt;br /&gt;
==Limitations==&lt;br /&gt;
The NOAEL has several limitations. It is dependent on the size of the study and the sensitivity of the measurements. It also does not account for individual variability in response to the substance.&lt;br /&gt;
&lt;br /&gt;
==See also==&lt;br /&gt;
* [[Lowest-observed-adverse-effect level]]&lt;br /&gt;
* [[Threshold limit value]]&lt;br /&gt;
* [[Acceptable daily intake]]&lt;br /&gt;
* [[Tolerable daily intake]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Toxicology]]&lt;br /&gt;
[[Category:Pharmacology]]&lt;br /&gt;
[[Category:Risk assessment]]&lt;br /&gt;
&lt;br /&gt;
{{stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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