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	<id>https://wikimd.com/index.php?action=history&amp;feed=atom&amp;title=Nigro_protocol</id>
	<title>Nigro protocol - Revision history</title>
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	<updated>2026-04-08T23:22:53Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=6530977&amp;oldid=prev</id>
		<title>Prab at 18:41, 18 March 2025</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=6530977&amp;oldid=prev"/>
		<updated>2025-03-18T18:41:42Z</updated>

		<summary type="html">&lt;p&gt;&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 18:41, 18 March 2025&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=6514661&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=6514661&amp;oldid=prev"/>
		<updated>2025-03-17T20:07:04Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 20:07, 17 March 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l34&quot;&gt;Line 34:&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=6237044&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=6237044&amp;oldid=prev"/>
		<updated>2025-02-10T18:07:50Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
				&lt;col class=&quot;diff-marker&quot; /&gt;
				&lt;col class=&quot;diff-content&quot; /&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 18:07, 10 February 2025&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l33&quot;&gt;Line 33:&lt;/td&gt;
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&lt;/table&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=5262590&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Nigro_protocol&amp;diff=5262590&amp;oldid=prev"/>
		<updated>2024-02-24T08:42:53Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Nigro Protocol&amp;#039;&amp;#039;&amp;#039;&lt;br /&gt;
&lt;br /&gt;
The &amp;#039;&amp;#039;&amp;#039;Nigro Protocol&amp;#039;&amp;#039;&amp;#039; is a preoperative treatment regimen used in the management of [[rectal cancer]]. It was developed by Dr. [[Norman Nigro]] in the 1970s and has since been widely adopted in the treatment of [[anal cancer]] and other types of [[cancer]].&lt;br /&gt;
&lt;br /&gt;
== History ==&lt;br /&gt;
&lt;br /&gt;
The Nigro Protocol was first introduced by Dr. Norman Nigro in 1974. He proposed the use of a combination of [[chemotherapy]] and [[radiotherapy]] as a preoperative treatment for rectal cancer. This approach was initially met with skepticism, but subsequent studies have confirmed its effectiveness.&lt;br /&gt;
&lt;br /&gt;
== Treatment Regimen ==&lt;br /&gt;
&lt;br /&gt;
The Nigro Protocol involves the administration of chemotherapy and radiotherapy before surgery. The chemotherapy typically consists of [[5-fluorouracil]] (5-FU) and [[mitomycin C]], while the radiotherapy is usually delivered at a dose of 30 Gy in 15 fractions.&lt;br /&gt;
&lt;br /&gt;
== Effectiveness ==&lt;br /&gt;
&lt;br /&gt;
Several studies have shown that the Nigro Protocol can significantly reduce the size of the tumor and improve the chances of successful surgery. It has also been found to improve survival rates and reduce the risk of recurrence.&lt;br /&gt;
&lt;br /&gt;
== Side Effects ==&lt;br /&gt;
&lt;br /&gt;
Like all cancer treatments, the Nigro Protocol can cause side effects. These may include [[nausea]], [[vomiting]], [[diarrhea]], and [[skin irritation]]. However, these side effects are usually manageable and subside once the treatment is completed.&lt;br /&gt;
&lt;br /&gt;
== See Also ==&lt;br /&gt;
&lt;br /&gt;
* [[Chemotherapy]]&lt;br /&gt;
* [[Radiotherapy]]&lt;br /&gt;
* [[Rectal Cancer]]&lt;br /&gt;
* [[Anal Cancer]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Medical treatments]]&lt;br /&gt;
[[Category:Cancer treatments]]&lt;br /&gt;
[[Category:Chemotherapy]]&lt;br /&gt;
[[Category:Radiotherapy]]&lt;br /&gt;
&lt;br /&gt;
{{stub}}&lt;br /&gt;
{{dictionary-stub1}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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