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← Older revision		Revision as of 06:25, 8 April 2025
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	[[File:Nevus_sebaceous.jpg\|~~thumb~~\|~~Nevus_sebaceous.jpg~~]] == ~~Nevus Sebaceous~~ ==		{{SI}}
			{{Infobox medical condition
			\| name = Nevus sebaceous
			\| image = [[File:Nevus_sebaceous.jpg\|250px]]
			\| caption = Nevus sebaceous on the scalp
			\| synonyms = Organoid nevus, Nevus sebaceus of Jadassohn
			\| field = [[Dermatology]]
			\| symptoms = Yellow-orange plaque, often on the scalp or face
			\| complications = Risk of [[basal cell carcinoma]], [[squamous cell carcinoma]], and other skin tumors
			\| onset = Present at birth or develops in early childhood
			\| duration = Lifelong
			\| causes = Congenital, due to genetic mutations
			\| risks = Increased risk of skin tumors
			\| diagnosis = Clinical examination, [[biopsy]]
			\| differential = [[Epidermal nevus]], [[seborrheic keratosis]], [[verruca vulgaris]]
			\| treatment = Surgical excision, monitoring for malignancy
			\| prognosis = Generally good with treatment, but requires monitoring
			\| frequency = Rare
			}}
	'''Nevus sebaceous''', also known as '''nevus sebaceus of Jadassohn''', is a congenital, benign [[hamartoma]] of the [[skin]] that typically presents at birth or in early childhood. It is characterized by an overgrowth of the [[sebaceous glands]], [[hair follicles]], and other epidermal structures.		'''Nevus sebaceous''', also known as '''nevus sebaceus of Jadassohn''', is a congenital, benign [[hamartoma]] of the [[skin]] that typically presents at birth or in early childhood. It is characterized by an overgrowth of the [[sebaceous glands]], [[hair follicles]], and other epidermal structures.

	== Presentation ==		== Presentation ==
	Nevus sebaceous usually appears as a solitary, well-demarcated, yellow-orange plaque. It is most commonly found on the [[scalp]], but it can also occur on the [[face]], [[neck]], or other areas of the body. The lesion tends to be hairless and may become more pronounced and nodular during [[puberty]] due to hormonal changes.		Nevus sebaceous usually appears as a solitary, well-demarcated, yellow-orange plaque. It is most commonly found on the [[scalp]], but it can also occur on the [[face]], [[neck]], or other areas of the body. The lesion tends to be hairless and may become more pronounced and nodular during [[puberty]] due to hormonal changes.

	== Pathophysiology ==		== Pathophysiology ==
	The exact cause of nevus sebaceous is not fully understood, but it is believed to result from a post-zygotic mutation in the [[HRAS]] or [[KRAS]] genes. These mutations lead to the abnormal development of the [[epidermis]], [[sebaceous glands]], and other skin appendages.		The exact cause of nevus sebaceous is not fully understood, but it is believed to result from a post-zygotic mutation in the [[HRAS]] or [[KRAS]] genes. These mutations lead to the abnormal development of the [[epidermis]], [[sebaceous glands]], and other skin appendages.

	== Diagnosis ==		== Diagnosis ==
	Diagnosis of nevus sebaceous is primarily clinical, based on the characteristic appearance of the lesion. A [[skin biopsy]] may be performed to confirm the diagnosis and to rule out other conditions. Histologically, nevus sebaceous shows hyperplasia of the sebaceous glands and other epidermal structures.		Diagnosis of nevus sebaceous is primarily clinical, based on the characteristic appearance of the lesion. A [[skin biopsy]] may be performed to confirm the diagnosis and to rule out other conditions. Histologically, nevus sebaceous shows hyperplasia of the sebaceous glands and other epidermal structures.

	== Complications ==		== Complications ==
	While nevus sebaceous is generally benign, there is a risk of secondary neoplasms developing within the lesion. These can include [[basal cell carcinoma]], [[squamous cell carcinoma]], and other benign or malignant tumors. Regular monitoring and, in some cases, prophylactic excision are recommended to manage this risk.		While nevus sebaceous is generally benign, there is a risk of secondary neoplasms developing within the lesion. These can include [[basal cell carcinoma]], [[squamous cell carcinoma]], and other benign or malignant tumors. Regular monitoring and, in some cases, prophylactic excision are recommended to manage this risk.

	== Treatment ==		== Treatment ==
	Treatment options for nevus sebaceous include surgical excision, which is often recommended to prevent the development of secondary neoplasms. Other treatments, such as laser therapy, may be used to improve the cosmetic appearance of the lesion.		Treatment options for nevus sebaceous include surgical excision, which is often recommended to prevent the development of secondary neoplasms. Other treatments, such as laser therapy, may be used to improve the cosmetic appearance of the lesion.

	== Prognosis ==		== Prognosis ==
	The prognosis for individuals with nevus sebaceous is generally good, especially if the lesion is monitored regularly and treated appropriately. The risk of malignant transformation is relatively low but warrants careful observation.		The prognosis for individuals with nevus sebaceous is generally good, especially if the lesion is monitored regularly and treated appropriately. The risk of malignant transformation is relatively low but warrants careful observation.

	== See Also ==		== See Also ==
	* [[Sebaceous gland]]		* [[Sebaceous gland]]
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	* [[Squamous cell carcinoma]]		* [[Squamous cell carcinoma]]
	* [[Skin biopsy]]		* [[Skin biopsy]]

	== References ==		== References ==
	{{Reflist}}		{{Reflist}}

	== External Links ==		== External Links ==
	{{Commons category\|Nevus sebaceous}}		{{Commons category\|Nevus sebaceous}}

	[[Category:Dermatology]]		[[Category:Dermatology]]
	[[Category:Congenital disorders]]		[[Category:Congenital disorders]]
	[[Category:Skin conditions resulting from errors in metabolism]]		[[Category:Skin conditions resulting from errors in metabolism]]
	[[Category:Neoplasms]]		[[Category:Neoplasms]]

	{{medicine-stub}}		{{medicine-stub}}

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2024-05-22T15:40:51Z

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[[File:Nevus_sebaceous.jpg|thumb|Nevus_sebaceous.jpg]] == Nevus Sebaceous ==

'''Nevus sebaceous''', also known as '''nevus sebaceus of Jadassohn''', is a congenital, benign [[hamartoma]] of the [[skin]] that typically presents at birth or in early childhood. It is characterized by an overgrowth of the [[sebaceous glands]], [[hair follicles]], and other epidermal structures.

== Presentation ==
Nevus sebaceous usually appears as a solitary, well-demarcated, yellow-orange plaque. It is most commonly found on the [[scalp]], but it can also occur on the [[face]], [[neck]], or other areas of the body. The lesion tends to be hairless and may become more pronounced and nodular during [[puberty]] due to hormonal changes.

== Pathophysiology ==
The exact cause of nevus sebaceous is not fully understood, but it is believed to result from a post-zygotic mutation in the [[HRAS]] or [[KRAS]] genes. These mutations lead to the abnormal development of the [[epidermis]], [[sebaceous glands]], and other skin appendages.

== Diagnosis ==
Diagnosis of nevus sebaceous is primarily clinical, based on the characteristic appearance of the lesion. A [[skin biopsy]] may be performed to confirm the diagnosis and to rule out other conditions. Histologically, nevus sebaceous shows hyperplasia of the sebaceous glands and other epidermal structures.

== Complications ==
While nevus sebaceous is generally benign, there is a risk of secondary neoplasms developing within the lesion. These can include [[basal cell carcinoma]], [[squamous cell carcinoma]], and other benign or malignant tumors. Regular monitoring and, in some cases, prophylactic excision are recommended to manage this risk.

== Treatment ==
Treatment options for nevus sebaceous include surgical excision, which is often recommended to prevent the development of secondary neoplasms. Other treatments, such as laser therapy, may be used to improve the cosmetic appearance of the lesion.

== Prognosis ==
The prognosis for individuals with nevus sebaceous is generally good, especially if the lesion is monitored regularly and treated appropriately. The risk of malignant transformation is relatively low but warrants careful observation.

== See Also ==
* [[Sebaceous gland]]
* [[Hamartoma]]
* [[Basal cell carcinoma]]
* [[Squamous cell carcinoma]]
* [[Skin biopsy]]

== References ==
{{Reflist}}

== External Links ==
{{Commons category|Nevus sebaceous}}

[[Category:Dermatology]]
[[Category:Congenital disorders]]
[[Category:Skin conditions resulting from errors in metabolism]]
[[Category:Neoplasms]]

{{medicine-stub}}

Nevus sebaceous - Revision history

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