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Neuregulin 1 - Revision history
2026-04-27T02:29:03Z
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<td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 20:10, 17 March 2025</td>
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2025-02-11T04:24:14Z
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<p><b>New page</b></p><div>'''Neuregulin 1''' (NRG1) is a [[protein]] encoded by the NRG1 [[gene]] in humans. It is a member of the [[neuregulin]] family of growth factors that are involved in cell growth and differentiation. <br />
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== Function ==<br />
NRG1 plays a crucial role in the growth, proliferation, and differentiation of a variety of cell types. It is involved in the development of the [[nervous system]], [[heart]], and [[breast]]. It is also implicated in the pathogenesis of certain diseases, including [[schizophrenia]] and [[cancer]].<br />
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== Structure ==<br />
The NRG1 gene is located on the short (p) arm of [[chromosome 8]] at position 12. The gene is composed of 23 exons spanning approximately 1.1 million base pairs. The encoded protein is a type I transmembrane protein that has an extracellular domain with an epidermal growth factor-like sequence.<br />
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== Role in Disease ==<br />
Several studies have suggested that mutations in the NRG1 gene may be associated with an increased risk of developing schizophrenia. Additionally, overexpression of NRG1 has been observed in certain types of cancer, including breast cancer.<br />
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== Therapeutic Potential ==<br />
Due to its role in cell growth and differentiation, NRG1 is being investigated as a potential therapeutic target for a variety of diseases, including cancer and neurological disorders.<br />
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== See Also ==<br />
* [[Neuregulin]]<br />
* [[Epidermal growth factor]]<br />
* [[Schizophrenia]]<br />
* [[Cancer]]<br />
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== References ==<br />
<references /><br />
<br />
[[Category:Proteins]]<br />
[[Category:Genes]]<br />
[[Category:Neuroscience]]<br />
[[Category:Oncology]]<br />
[[Category:Cardiology]]<br />
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