https://wikimd.org/index.php?action=history&feed=atom&title=NetarsudilNetarsudil - Revision history2026-05-11T23:16:07ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=Netarsudil&diff=2412110&oldid=prevDeepika vegiraju at 13:01, 8 August 20212021-08-08T13:01:59Z<p></p>
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== '''What is Netarsudil?''' ==<br />
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* Netarsudil ('''RHOPRESSA''') (netarsudil ophthalmic solution) 0.02% is a '''Rho kinase inhibitor''' used for the reduction of elevated [[intraocular pressure]] (IOP) in patients with [[Open angle glaucoma|open-angle glaucoma]] or [[ocular hypertension]].<br />
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[[File:Netarsudil.svg|thumb]]<br />
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== '''What are the uses of this medicine?''' ==<br />
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* This medicine is used for the reduction of elevated [[intraocular pressure]] (IOP) in patients with [[Open angle glaucoma|open-angle glaucoma]] or [[ocular hypertension]].<br />
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== '''How does this medicine work?''' ==<br />
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* {{PAGENAME}} - an amino-isoquinoline amide and '''inhibitor of rho kinase (rock) and norepinephrine transporter (net)''', with potential intraocular pressure (iop)-lowering activity. <br />
* Upon ocular administration, netarsudil '''inhibits rock and the rho pathway''', '''increases aqueous humor (ah) outflow via the trabecular pathway''', and lowers iop. <br />
* In addition, netarsudil '''may lower iop by decreasing episcleral venous pressure and decreasing the production of aqueous humor''' through inhibition of net.<br />
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== '''Who Should Not Use this medicine ?''' ==<br />
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* This medcine have no usage limitations.<br />
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== '''What drug interactions can this medicine cause?''' ==<br />
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* No clinically important drug interactions have been observed with RHOPRESSA.<br />
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== '''Is this medicine FDA approved?''' ==<br />
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* It was approved for use in the United States in 2017.<br />
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== '''How should this medicine be used?''' ==<br />
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'''Recommended Dosageː '''<br />
The recommended dosage is '''one drop in the affected eye(s) once daily''' in the evening.<br />
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'''Administration'''<br />
* Take RHOPRESSA exactly as your doctor tells you to take it.<br />
* Take RHOPRESSA one drop in the affected eye(s) once daily in the evening.<br />
* If one dose is missed, treatment should continue with the next dose in the evening. <br />
* Twice a day dosing is not well tolerated and is not recommended. <br />
* If RHOPRESSA is to be used concomitantly with other topical ophthalmic drug products to lower IOP, administer each drug product at least 5 minutes apart.<br />
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== '''What are the dosage forms and brand names of this medicine?''' ==<br />
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This medicine is available in fallowing doasage form:<br />
* '''As Ophthalmic solution''' containing 0.2 mg/mL of netarsudil.<br />
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This medicine is available in fallowing brand namesː<br />
*'''RHOPRESSA'''<br />
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=='''What side effects can this medication cause?'''==<br />
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The most common side effects of this medicine include:<br />
* conjunctival [[hyperemia]] <br />
* corneal [[verticillata]]<br />
* instillation site pain<br />
* conjunctival [[hemorrhage]]<br />
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==''' What special precautions should I follow?''' ==<br />
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* Contact lenses should be removed prior to [[instillation]] of RHOPRESSA and may be reinserted 15 minutes following its administration.<br />
* Advise patients that if more than one topical [[ophthalmic]] drug is being used, the drugs should be administered at least 5 minutes between applications.<br />
* Instruct patients to avoid allowing the tip of the dispensing container to contact the eye, surrounding structures, fingers, or any other surface in order to minimize contamination of the solution. <br />
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== '''What to do in case of emergency/overdose?''' ==<br />
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* {{overdose}}<br />
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== '''Can this medicine be used in pregnancy?''' ==<br />
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* There are no available data on RHOPRESSA use in pregnant women.<br />
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=='''Can this medicine be used in children?'''==<br />
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* Safety and effectiveness in pediatric patients below the age of 18 years have not been established.<br />
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== '''What are the active and inactive ingredients in this medicine?''' ==<br />
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'''Active ingredient:'''<br />
* NETARSUDIL MESYLATE<br />
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'''Inactive ingredients:'''<br />
* BENZALKONIUM CHLORIDE <br />
* MANNITOL <br />
* BORIC ACID <br />
* SODIUM HYDROXIDE <br />
* WATER<br />
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== '''Who manufactures and distributes this medicine?''' ==<br />
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* '''Packager:''' [[Aerie Pharmaceuticals]], Inc.<br />
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== '''What should I know about storage and disposal of this medication?''' ==<br />
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* Store at 2°C to 8°C (36°F to 46°F) until opened. After opening, the product may be kept at 2°C to 25°C (36°F to 77°F) for up to 6 weeks. <br />
* If after opening the product is kept refrigerated at 2°C to 8°C (36°F to 46°F), then the product can be used until the expiration date stamped on the bottle. <br />
* During shipment, the bottle may be maintained at temperatures up to 40°C (104°F) for a period not exceeding 14 days.<br />
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{{coststubd}}<br />
{{Antiglaucoma preparations and miotics}}<br />
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[[Category:Ophthalmology drugs]]<br />
[[Category:Isoquinolines]]<br />
[[Category:Benzoate esters]]<br />
{{medicine-stub}}</div>Deepika vegiraju