Nesfatin-1 - Revision history

Prab: /* Nesfatin-1 gallery */

2025-03-09T03:23:29Z

Nesfatin-1 gallery

← Older revision		Revision as of 03:23, 9 March 2025
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	[[Category:Endocrinology]]		[[Category:Endocrinology]]
	[[Category:Metabolism]]		[[Category:Metabolism]]
	~~== Nesfatin-1 gallery ==~~
	~~<gallery>~~
	~~File:Nesfatin-1 glucose-dependent insulin release.jpg\|Nesfatin-1 glucose-dependent insulin release~~
	~~File:Nesfatin Sequence.gif\|Nesfatin Sequence~~
	~~File:Insulin Signal Transduction Pathways.jpg\|Insulin Signal Transduction Pathways~~
	~~</gallery>~~

Prab: CSV import

2025-03-03T05:06:34Z

CSV import

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	[[Category:Endocrinology]]		[[Category:Endocrinology]]
	[[Category:Metabolism]]		[[Category:Metabolism]]
			== Nesfatin-1 gallery ==
			<gallery>
			File:Nesfatin-1 glucose-dependent insulin release.jpg\|Nesfatin-1 glucose-dependent insulin release
			File:Nesfatin Sequence.gif\|Nesfatin Sequence
			File:Insulin Signal Transduction Pathways.jpg\|Insulin Signal Transduction Pathways
			</gallery>

Prab at 01:34, 24 February 2025

2025-02-24T01:34:42Z

← Older revision		Revision as of 01:34, 24 February 2025
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	[[Category:Endocrinology]]		[[Category:Endocrinology]]
	[[Category:Metabolism]]		[[Category:Metabolism]]
	~~== Nesfatin-1 ==~~
	~~<gallery>~~
	~~File:Nesfatin-1_glucose-dependent_insulin_release.jpg\|Nesfatin-1 glucose-dependent insulin release~~
	~~File:Nesfatin_Sequence.gif\|Nesfatin Sequence~~
	~~File:Insulin_Signal_Transduction_Pathways.jpg\|Insulin Signal Transduction Pathways~~
	~~</gallery>~~

Prab: CSV import

2025-02-23T21:09:37Z

CSV import

← Older revision		Revision as of 21:09, 23 February 2025
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	[[Category:Endocrinology]]		[[Category:Endocrinology]]
	[[Category:Metabolism]]		[[Category:Metabolism]]
			== Nesfatin-1 ==
			<gallery>
			File:Nesfatin-1_glucose-dependent_insulin_release.jpg\|Nesfatin-1 glucose-dependent insulin release
			File:Nesfatin_Sequence.gif\|Nesfatin Sequence
			File:Insulin_Signal_Transduction_Pathways.jpg\|Insulin Signal Transduction Pathways
			</gallery>

Prab at 15:11, 22 February 2025

2025-02-22T15:11:25Z

← Older revision		Revision as of 15:11, 22 February 2025
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	==Structure==		==Structure==
	~~[[File:Nesfatin_Sequence.gif\|thumb\|left\|Nesfatin-1 sequence]]~~
	Nesfatin-1 is a peptide consisting of 82 amino acids. It is derived from the N-terminal region of the precursor protein NUCB2. The sequence of nesfatin-1 is highly conserved across different species, indicating its important physiological role.		Nesfatin-1 is a peptide consisting of 82 amino acids. It is derived from the N-terminal region of the precursor protein NUCB2. The sequence of nesfatin-1 is highly conserved across different species, indicating its important physiological role.

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	==Mechanism of Action==		==Mechanism of Action==
	~~[[File:Nesfatin-1_glucose-dependent_insulin_release.jpg\|thumb\|right\|Nesfatin-1 and glucose-dependent insulin release]]~~
	Nesfatin-1 influences energy homeostasis by modulating the release of various hormones. It has been shown to stimulate the release of insulin in a glucose-dependent manner, thereby playing a role in glucose metabolism. The peptide interacts with specific receptors in the brain to exert its anorexigenic effects.		Nesfatin-1 influences energy homeostasis by modulating the release of various hormones. It has been shown to stimulate the release of insulin in a glucose-dependent manner, thereby playing a role in glucose metabolism. The peptide interacts with specific receptors in the brain to exert its anorexigenic effects.

	==Role in Insulin Signaling==		==Role in Insulin Signaling==
	~~[[File:Insulin_Signal_Transduction_Pathways.jpg\|thumb\|left\|Insulin signal transduction pathways]]~~
	Nesfatin-1 is involved in the regulation of insulin signaling pathways. It enhances insulin sensitivity and promotes glucose uptake in peripheral tissues. This action is crucial for maintaining normal blood glucose levels and preventing metabolic disorders such as diabetes.		Nesfatin-1 is involved in the regulation of insulin signaling pathways. It enhances insulin sensitivity and promotes glucose uptake in peripheral tissues. This action is crucial for maintaining normal blood glucose levels and preventing metabolic disorders such as diabetes.

Prab: CSV import

2025-02-21T14:18:33Z

CSV import

← Older revision		Revision as of 14:18, 21 February 2025
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	~~== Nesfatin-1 ==~~		{{Short description\|Peptide involved in appetite regulation and energy homeostasis}}

	'''Nesfatin-1''' is a [[peptide]] that plays a significant role in the regulation of [[appetite]] and [[energy homeostasis]]. It is derived from the precursor protein nucleobindin-2 (NUCB2) and is expressed in various tissues, including the [[hypothalamus]], [[pancreas]], and [[adipose tissue]].		'''Nesfatin-1''' is a peptide that plays a significant role in the regulation of appetite and energy homeostasis. It is derived from the precursor protein nucleobindin-2 (NUCB2) and is expressed in various tissues, including the hypothalamus, pancreas, and adipose tissue.

	=== Structure ~~and Synthesis =~~==		==Structure==
	Nesfatin-1 is a peptide consisting of 82 amino acids~~, which~~ is ~~cleaved~~ from the N-terminal region of the NUCB2 ~~protein~~. The ~~NUCB2 gene is located on chromosome 11 in humans. Nesfatin~~-1 is ~~synthesized in the [[endoplasmic reticulum]] and undergoes post-translational modifications before being secreted into the [[circulatory system]]~~.		[[File:Nesfatin_Sequence.gif\|thumb\|left\|Nesfatin-1 sequence]]
			Nesfatin-1 is a peptide consisting of 82 amino acids. It is derived from the N-terminal region of the precursor protein NUCB2. The sequence of nesfatin-1 is highly conserved across different species, indicating its important physiological role.

	=== Function ===		==Function==
	Nesfatin-1 is involved in the regulation of [[food intake]] and [[body weight]]. It acts as an anorexigenic ~~factor~~, meaning it suppresses appetite. Nesfatin-1 exerts its effects by ~~interacting with specific receptors in~~ the [[central nervous system]], particularly in the hypothalamus, which is a critical ~~area~~ for the ~~control~~ of hunger and satiety.		Nesfatin-1 is involved in the regulation of food intake and body weight. It acts as an anorexigenic peptide, meaning it suppresses appetite. Nesfatin-1 exerts its effects by acting on the central nervous system, particularly the hypothalamus, which is a critical region for the regulation of hunger and satiety.

	==== ~~Appetite Regulation ====~~		==Mechanism of Action==
	Nesfatin-1 ~~reduces food intake~~ by ~~influencing~~ the ~~activity~~ of ~~neurons in the hypothalamus~~. It has been shown to ~~decrease meal size and prolong~~ the ~~interval between meals~~. ~~This~~ peptide ~~also~~ interacts with ~~other appetite-regulating hormones such as [[leptin]] and [[ghrelin]], enhancing~~ its anorexigenic effects.		[[File:Nesfatin-1_glucose-dependent_insulin_release.jpg\|thumb\|right\|Nesfatin-1 and glucose-dependent insulin release]]
			Nesfatin-1 influences energy homeostasis by modulating the release of various hormones. It has been shown to stimulate the release of insulin in a glucose-dependent manner, thereby playing a role in glucose metabolism. The peptide interacts with specific receptors in the brain to exert its anorexigenic effects.

	==== ~~Energy Homeostasis ====~~		==Role in Insulin Signaling==
	~~In addition to its role in appetite suppression, nesfatin~~-1 is involved in the regulation of ~~energy expenditure~~. It ~~influences [[thermogenesis]]~~ and ~~[[lipid metabolism]], contributing to the maintenance of energy balance~~ in ~~the body~~.		[[File:Insulin_Signal_Transduction_Pathways.jpg\|thumb\|left\|Insulin signal transduction pathways]]
			Nesfatin-1 is involved in the regulation of insulin signaling pathways. It enhances insulin sensitivity and promotes glucose uptake in peripheral tissues. This action is crucial for maintaining normal blood glucose levels and preventing metabolic disorders such as diabetes.

	=== Clinical Significance ===		==Clinical Significance==
	~~Nesfatin-1 has been studied for~~ its ~~potential~~ role in ~~[[obesity]]~~ and ~~[[metabolic disorders]]. Alterations in~~ nesfatin-1 ~~levels have been observed in individuals with~~ obesity~~, suggesting a possible link between nesfatin-1 dysregulation~~ and ~~excessive weight gain~~. ~~Furthermore,~~ nesfatin-1 ~~may have implications in the management of [[type 2 diabetes mellitus]], as it~~ influences ~~insulin secretion and glucose metabolism~~.		Due to its role in appetite regulation and energy balance, nesfatin-1 is being studied as a potential therapeutic target for obesity and related metabolic disorders. Understanding the mechanisms by which nesfatin-1 influences energy homeostasis could lead to new treatments for these conditions.

	==~~= Research Directions =~~==		==Related pages==
	Ongoing research is exploring the therapeutic potential of nesfatin-1 in treating obesity and related metabolic conditions. Studies are also investigating the molecular mechanisms underlying its effects on appetite and energy balance, as well as its interactions with other neuropeptides and hormones.		* [[Insulin]]
			* [[Hypothalamus]]
	~~== Related Pages ==~~
	* [[Appetite regulation]]		* [[Appetite regulation]]
	* [[~~Hypothalamus~~]]		* [[Energy homeostasis]]
	* [[Obesity]]
	* [[Leptin]]
	* [[Ghrelin]]

	~~{{Peptide hormones}}~~

	[[Category:Peptides]]		[[Category:Peptides]]
	[[Category:Endocrinology]]		[[Category:Endocrinology]]
	[[Category:~~Neuroendocrinology~~]]		[[Category:Metabolism]]
	~~== Nesfatin-1 ==~~
	~~<gallery>~~
	~~File:Nesfatin-1 glucose-dependent insulin release.jpg\|Nesfatin-1 glucose-dependent insulin release~~
	~~File:Nesfatin Sequence.gif\|Nesfatin Sequence~~
	~~File:Insulin Signal Transduction Pathways.jpg\|Insulin Signal Transduction Pathways~~
	~~</gallery>~~
	~~== Nesfatin-1 ==~~
	~~<gallery>~~
	~~File:Nesfatin-1 glucose-dependent insulin release.jpg\|Nesfatin-1 glucose-dependent insulin release~~
	~~File:Nesfatin Sequence.gif\|Nesfatin Sequence~~
	~~File:Insulin Signal Transduction Pathways.jpg\|Insulin Signal Transduction Pathways~~
	~~</gallery>~~

Prab: CSV import

2025-02-20T01:45:24Z

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← Older revision		Revision as of 01:45, 20 February 2025
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	[[Category:Endocrinology]]		[[Category:Endocrinology]]
	[[Category:Neuroendocrinology]]		[[Category:Neuroendocrinology]]
			== Nesfatin-1 ==
			<gallery>
			File:Nesfatin-1 glucose-dependent insulin release.jpg\|Nesfatin-1 glucose-dependent insulin release
			File:Nesfatin Sequence.gif\|Nesfatin Sequence
			File:Insulin Signal Transduction Pathways.jpg\|Insulin Signal Transduction Pathways
			</gallery>
	== Nesfatin-1 ==		== Nesfatin-1 ==
	<gallery>		<gallery>

Prab: CSV import

2025-02-20T01:21:09Z

CSV import

← Older revision		Revision as of 01:21, 20 February 2025
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	[[Category:Endocrinology]]		[[Category:Endocrinology]]
	[[Category:Neuroendocrinology]]		[[Category:Neuroendocrinology]]
			== Nesfatin-1 ==
			<gallery>
			File:Nesfatin-1 glucose-dependent insulin release.jpg\|Nesfatin-1 glucose-dependent insulin release
			File:Nesfatin Sequence.gif\|Nesfatin Sequence
			File:Insulin Signal Transduction Pathways.jpg\|Insulin Signal Transduction Pathways
			</gallery>

Prab: CSV import

2025-02-18T17:44:41Z

CSV import

← Older revision		Revision as of 17:44, 18 February 2025
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	~~'''~~Nesfatin-1~~''' is a protein that is encoded by the NUCB2 gene in humans. It is involved in the regulation of appetite and body weight.~~		== Nesfatin-1 ==

	~~== Function ==~~		'''Nesfatin-1''' is a [[peptide]] that plays a significant role in the regulation of [[appetite]] and [[energy homeostasis]]. It is derived from the precursor protein nucleobindin-2 (NUCB2) and is expressed in various tissues, including the [[hypothalamus]], [[pancreas]], and [[adipose tissue]].
	Nesfatin-1 is a peptide ~~hormone produced~~ in the ~~hypothalamus, a region~~ of ~~the brain that regulates hunger~~ and ~~satiety~~. It is ~~also found~~ in ~~other~~ tissues, including the ~~stomach and~~ pancreas~~. Nesfatin-1 suppresses food intake~~ and ~~reduces body weight. It is thought to act by influencing the activity of neurons in the hypothalamus that control appetite~~.

	== ~~Role in Disease~~ ==		=== Structure and Synthesis ===
	~~Alterations in the levels of nesfatin~~-1 ~~have been associated with several diseases~~, ~~including obesity, diabetes, and depression~~. ~~In obesity, levels of nesfatin-1 are often reduced, while~~ in ~~diabetes, they may be increased~~. ~~The role of nesfatin~~-1 ~~in depression~~ is ~~less clear, but it may be involved~~ in the ~~regulation of mood~~ and ~~stress responses~~.		Nesfatin-1 is a peptide consisting of 82 amino acids, which is cleaved from the N-terminal region of the NUCB2 protein. The NUCB2 gene is located on chromosome 11 in humans. Nesfatin-1 is synthesized in the [[endoplasmic reticulum]] and undergoes post-translational modifications before being secreted into the [[circulatory system]].

	== ~~Research~~ ==		=== Function ===
	~~Research on nesfatin~~-1 is ~~ongoing, with studies investigating its potential as a target for~~ the ~~treatment~~ of ~~obesity~~ and ~~other metabolic disorders~~. ~~Some studies have also suggested that nesfatin~~-1 ~~may have anti-inflammatory~~ effects, which ~~could be beneficial in~~ the ~~treatment~~ of ~~diseases such as rheumatoid arthritis~~ and ~~inflammatory bowel disease~~.		Nesfatin-1 is involved in the regulation of [[food intake]] and [[body weight]]. It acts as an anorexigenic factor, meaning it suppresses appetite. Nesfatin-1 exerts its effects by interacting with specific receptors in the [[central nervous system]], particularly in the hypothalamus, which is a critical area for the control of hunger and satiety.

	== ~~See Also~~ ==		==== Appetite Regulation ====
	* [[~~NUCB2~~]]		Nesfatin-1 reduces food intake by influencing the activity of neurons in the hypothalamus. It has been shown to decrease meal size and prolong the interval between meals. This peptide also interacts with other appetite-regulating hormones such as [[leptin]] and [[ghrelin]], enhancing its anorexigenic effects.

			==== Energy Homeostasis ====
			In addition to its role in appetite suppression, nesfatin-1 is involved in the regulation of energy expenditure. It influences [[thermogenesis]] and [[lipid metabolism]], contributing to the maintenance of energy balance in the body.

			=== Clinical Significance ===
			Nesfatin-1 has been studied for its potential role in [[obesity]] and [[metabolic disorders]]. Alterations in nesfatin-1 levels have been observed in individuals with obesity, suggesting a possible link between nesfatin-1 dysregulation and excessive weight gain. Furthermore, nesfatin-1 may have implications in the management of [[type 2 diabetes mellitus]], as it influences insulin secretion and glucose metabolism.

			=== Research Directions ===
			Ongoing research is exploring the therapeutic potential of nesfatin-1 in treating obesity and related metabolic conditions. Studies are also investigating the molecular mechanisms underlying its effects on appetite and energy balance, as well as its interactions with other neuropeptides and hormones.

			== Related Pages ==
			* [[Appetite regulation]]
	* [[Hypothalamus]]		* [[Hypothalamus]]
	* [[Obesity]]		* [[Obesity]]
	* [[~~Diabetes~~]]		* [[Leptin]]
	* [[~~Depression~~]]		* [[Ghrelin]]

	~~== References ==~~
	~~<references />~~

	~~[[Category:Proteins]]~~		{{Peptide hormones}}
	~~[[Category:Hormones]]~~
	~~[[Category:Appetite]]~~
	~~[[Category:Obesity]]~~
	~~[[Category:Diabetes]]~~
	~~[[Category:Depression]]~~

	~~{{stub}}~~		[[Category:Peptides]]
	~~<gallery>~~		[[Category:Endocrinology]]
	~~File~~:~~Nesfatin-1_glucose-dependent_insulin_release.jpg\|Nesfatin-1 glucose-dependent insulin release~~		[[Category:Neuroendocrinology]]
	~~File~~:~~Nesfatin_Sequence.gif\|Nesfatin Sequence~~
	~~File~~:~~Insulin_Signal_Transduction_Pathways.jpg\|Insulin Signal Transduction Pathways~~
	~~</gallery>~~

Prab: CSV import

2025-02-18T04:02:23Z

CSV import

← Older revision		Revision as of 04:02, 18 February 2025
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	{{stub}}		{{stub}}
			<gallery>
			File:Nesfatin-1_glucose-dependent_insulin_release.jpg\|Nesfatin-1 glucose-dependent insulin release
			File:Nesfatin_Sequence.gif\|Nesfatin Sequence
			File:Insulin_Signal_Transduction_Pathways.jpg\|Insulin Signal Transduction Pathways
			</gallery>