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	'''Nemonapride''' is an [[antipsychotic]] ~~agent~~ used in the treatment of [[schizophrenia~~]]. It is a [[dopamine antagonist~~]] and ~~specifically blocks~~ [[~~dopamine D2 receptor\|D2 receptors~~]] and ~~[[serotonin receptor\|serotonin 5-HT1A receptors]], which~~ is ~~thought to have beneficial~~ effects ~~on the [[negative symptoms]] of schizophrenia~~.		{{Short description\|Overview of the antipsychotic medication Nemonapride}}
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			'''Nemonapride''' is an atypical [[antipsychotic]] medication primarily used in the treatment of [[schizophrenia]] and other [[psychotic disorders]]. It is known for its unique pharmacological profile and is utilized in certain countries for its therapeutic effects.

	==Pharmacology==		==Pharmacology==
	Nemonapride ~~acts~~ as an antagonist at the [[D2 receptor]], which is ~~found~~ in ~~the~~ [[~~brain~~]]~~. In particular~~, it ~~has high affinity~~ for the ~~D2 receptors~~ in ~~the~~ [[~~mesolimbic pathway~~]], ~~which~~ is ~~associated with the~~ effects of ~~antipsychotic drugs~~. ~~Nemonapride~~ also ~~has high affinity for the~~ [[~~5-HT1A receptor~~]]~~, which is thought~~ to ~~contribute~~ to ~~its effects on negative symptoms~~ and ~~cognitive function~~.		Nemonapride functions as a selective [[dopamine receptor]] antagonist, with a high affinity for the [[D2 receptor\|D2]] and [[D3 receptor\|D3]] subtypes. This action helps in modulating the dopaminergic activity in the brain, which is often dysregulated in psychotic disorders. Unlike typical antipsychotics, nemonapride has a lower incidence of [[extrapyramidal symptoms]], making it a preferable option for some patients.

			==Clinical Use==
			Nemonapride is primarily indicated for the management of schizophrenia. It is effective in reducing both positive symptoms, such as [[hallucinations]] and [[delusions]], and negative symptoms, such as [[anhedonia]] and [[social withdrawal]]. The medication is administered orally and is typically prescribed in a controlled dosage to minimize potential side effects.

			==Side Effects==
			Common side effects of nemonapride include [[sedation]], [[weight gain]], and [[gastrointestinal disturbances]]. Due to its dopaminergic activity, there is also a risk of developing [[tardive dyskinesia]] with long-term use. Patients are advised to undergo regular monitoring to manage and mitigate these risks.

	==~~Clinical use~~==		==Mechanism of Action==
	Nemonapride ~~is used in~~ the ~~treatment~~ of ~~schizophrenia~~. ~~It has been found to be effective in reducing both~~ the ~~positive and negative symptoms~~ of ~~the disease. The drug is also used~~ in the ~~treatment~~ of ~~other psychiatric disorders~~, ~~such as~~ [[~~bipolar disorder]] and [[major depressive disorder~~]].		[[File:Nemonapride.svg\|thumb\|right\|Chemical structure of Nemonapride]]
			Nemonapride's mechanism of action involves the blockade of dopamine receptors, particularly the D2 and D3 subtypes. This blockade reduces the overactivity of dopamine pathways that are implicated in the pathophysiology of schizophrenia. Additionally, nemonapride may have some affinity for [[serotonin receptors]], contributing to its atypical profile.

	==~~Side effects~~==		==History and Development==
	~~The most common side effects of nemonapride are [[extrapyramidal symptoms]], which include [[tremor]], [[rigidity]],~~ and ~~[[bradykinesia]]~~. ~~Other~~ side effects ~~can include [~~[~~insomnia]],~~ [~~[anxiety~~]]~~, and [[nausea]]. In rare cases, nemonapride can cause [[neuroleptic malignant syndrome]], a potentially life-threatening condition~~.		Nemonapride was developed in Japan and has been used in clinical practice since the late 20th century. Its development was part of a broader effort to create antipsychotic medications with fewer side effects compared to earlier drugs like [[haloperidol]].

	==~~See also~~==		==Related pages==
	* [[Antipsychotic]]		* [[Antipsychotic]]
	* [[Dopamine ~~antagonist~~]]		* [[Schizophrenia]]
	* [[~~Serotonin receptor antagonist~~]]		* [[Dopamine receptor]]
			* [[Tardive dyskinesia]]

	[[Category:Antipsychotics]]		[[Category:Antipsychotics]]
	[[Category:Dopamine antagonists]]		[[Category:Dopamine antagonists]]
	~~[[Category:Serotonin receptor antagonists]]~~

	~~{{stub}}~~

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'''Nemonapride''' is an [[antipsychotic]] agent used in the treatment of [[schizophrenia]]. It is a [[dopamine antagonist]] and specifically blocks [[dopamine D2 receptor|D2 receptors]] and [[serotonin receptor|serotonin 5-HT1A receptors]], which is thought to have beneficial effects on the [[negative symptoms]] of schizophrenia.

==Pharmacology==
Nemonapride acts as an antagonist at the [[D2 receptor]], which is found in the [[brain]]. In particular, it has high affinity for the D2 receptors in the [[mesolimbic pathway]], which is associated with the effects of antipsychotic drugs. Nemonapride also has high affinity for the [[5-HT1A receptor]], which is thought to contribute to its effects on negative symptoms and cognitive function.

==Clinical use==
Nemonapride is used in the treatment of schizophrenia. It has been found to be effective in reducing both the positive and negative symptoms of the disease. The drug is also used in the treatment of other psychiatric disorders, such as [[bipolar disorder]] and [[major depressive disorder]].

==Side effects==
The most common side effects of nemonapride are [[extrapyramidal symptoms]], which include [[tremor]], [[rigidity]], and [[bradykinesia]]. Other side effects can include [[insomnia]], [[anxiety]], and [[nausea]]. In rare cases, nemonapride can cause [[neuroleptic malignant syndrome]], a potentially life-threatening condition.

==See also==
* [[Antipsychotic]]
* [[Dopamine antagonist]]
* [[Serotonin receptor antagonist]]

[[Category:Antipsychotics]]
[[Category:Dopamine antagonists]]
[[Category:Serotonin receptor antagonists]]

{{stub}}

Nemonapride - Revision history

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