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	<title>Nectin - Revision history</title>
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	<updated>2026-04-08T12:55:58Z</updated>
	<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>https://wikimd.com/index.php?title=Nectin&amp;diff=6514387&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Nectin&amp;diff=6514387&amp;oldid=prev"/>
		<updated>2025-03-17T19:52:42Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 19:52, 17 March 2025&lt;/td&gt;
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		<author><name>Prab</name></author>
	</entry>
	<entry>
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		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Nectin&amp;diff=6275417&amp;oldid=prev"/>
		<updated>2025-02-11T04:22:46Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;table style=&quot;background-color: #fff; color: #202122;&quot; data-mw=&quot;interface&quot;&gt;
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				&lt;td colspan=&quot;2&quot; style=&quot;background-color: #fff; color: #202122; text-align: center;&quot;&gt;Revision as of 04:22, 11 February 2025&lt;/td&gt;
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		<author><name>Prab</name></author>
	</entry>
	<entry>
		<id>https://wikimd.com/index.php?title=Nectin&amp;diff=5302226&amp;oldid=prev</id>
		<title>Prab: CSV import</title>
		<link rel="alternate" type="text/html" href="https://wikimd.com/index.php?title=Nectin&amp;diff=5302226&amp;oldid=prev"/>
		<updated>2024-02-25T23:27:10Z</updated>

		<summary type="html">&lt;p&gt;CSV import&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;&amp;#039;&amp;#039;&amp;#039;Nectin&amp;#039;&amp;#039;&amp;#039; is a family of [[cell adhesion molecule|cell adhesion molecules]] which are involved in a variety of cellular processes including [[cell migration]], [[cell proliferation]], and [[cell survival]]. Nectins are expressed in a variety of tissues and are involved in the formation of [[cell junctions]], particularly [[adherens junctions]] and [[tight junctions]]. &lt;br /&gt;
&lt;br /&gt;
== Structure ==&lt;br /&gt;
&lt;br /&gt;
Nectins are type I [[transmembrane protein|transmembrane proteins]] that consist of three [[immunoglobulin]]-like domains, a single transmembrane segment, and a cytoplasmic tail. The extracellular portion of the nectin molecule is responsible for mediating cell-cell adhesion, while the cytoplasmic tail interacts with intracellular [[cytoskeletal]] proteins.&lt;br /&gt;
&lt;br /&gt;
== Function ==&lt;br /&gt;
&lt;br /&gt;
Nectins function as cell adhesion molecules, mediating cell-cell adhesion through homophilic and heterophilic interactions. These interactions are important for the formation and maintenance of cell junctions. In addition to their role in cell adhesion, nectins also play a role in cell signaling. They can interact with other proteins to activate signaling pathways that regulate cell migration, proliferation, and survival.&lt;br /&gt;
&lt;br /&gt;
== Clinical significance ==&lt;br /&gt;
&lt;br /&gt;
Mutations in nectin genes have been associated with several human diseases. For example, mutations in the gene encoding nectin-1 have been linked to [[herpes simplex virus]] infection, as nectin-1 is a primary receptor for the virus. Mutations in the gene encoding nectin-4 have been associated with [[cancer]], as overexpression of nectin-4 has been observed in several types of cancer.&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
&lt;br /&gt;
* [[Cell adhesion]]&lt;br /&gt;
* [[Cell junction]]&lt;br /&gt;
* [[Transmembrane protein]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Cell biology]]&lt;br /&gt;
[[Category:Proteins]]&lt;br /&gt;
[[Category:Genes]]&lt;br /&gt;
&lt;br /&gt;
{{stub}}&lt;/div&gt;</summary>
		<author><name>Prab</name></author>
	</entry>
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