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	~~'''~~Narcotoline''' is an [[opiate]] alkaloid that is found in [[opium]]. It is a minor constituent of opium, accounting for less than 1% of the total alkaloid content. Despite its low concentration, narcotoline has been the subject of scientific research due to its potential pharmacological properties.		== Narcotoline ==

	~~==Chemistry==~~		[[File:Narcotoline_structure.png\|thumb\|right\|Chemical structure of Narcotoline]]

	Narcotoline is ~~a member of~~ the [[~~benzylisoquinoline~~]] ~~class~~ of alkaloids~~. It~~ is structurally related to other ~~opiate~~ alkaloids such as [[morphine]], [[codeine]]~~, and [[thebaine]]. The chemical structure of narcotoline consists of a benzylisoquinoline core, with additional functional groups that contribute to its pharmacological activity~~.		'''Narcotoline''' is an alkaloid compound found in certain plants, particularly those belonging to the [[Papaveraceae]] family. It is one of the many alkaloids present in the opium poppy, [[Papaver somniferum]], and is structurally related to other opium alkaloids such as [[morphine]] and [[codeine]].

	==~~Pharmacology~~==		== Chemical Structure ==

	The ~~pharmacological properties~~ of narcotoline ~~are not well understood. As an opiate alkaloid~~, it ~~is believed to interact with the [[opioid receptors]] in the brain, potentially producing analgesic effects~~. ~~However~~, ~~the potency~~ and ~~efficacy of narcotoline at these receptors is not known. Further research is needed~~ to ~~fully elucidate the pharmacological~~ activity ~~of this compound~~.		Narcotoline is characterized by its complex chemical structure, which includes a benzylisoquinoline skeleton. The molecular formula of narcotoline is C21H21NO7, and it has a molecular weight of 399.4 g/mol. The structure of narcotoline includes several functional groups, such as methoxy and hydroxyl groups, which contribute to its chemical properties and biological activity.

	==~~Toxicology~~==		== Biological Activity ==

	~~The toxicological profile~~ of ~~narcotoline~~ is ~~also~~ not well ~~characterized~~. ~~As a minor constituent of opium~~, it is ~~likely to contribute to the overall toxicity~~ of ~~this substance~~. ~~However~~, ~~the specific toxic effects~~ of ~~narcotoline, as well as its lethal dose, are not known~~.		Narcotoline exhibits a range of biological activities, although it is not as well-studied as other opium alkaloids like morphine. It has been reported to have mild analgesic properties, but its potency is significantly lower than that of morphine. Narcotoline may also have antitussive (cough suppressant) effects, similar to those of codeine.

	==~~History and Legal Status~~==		== Pharmacology ==

	~~Narcotoline was first isolated from opium in~~ the ~~19th century~~. ~~Its chemical structure was determined in the early 20th century. Currently~~, ~~narcotoline~~ is not ~~specifically regulated under international drug control treaties~~. ~~However~~, ~~as a constituent of opium~~, it ~~is indirectly controlled under the provisions that regulate opium and its derivatives~~.		The pharmacological effects of narcotoline are primarily due to its interaction with the [[central nervous system]]. However, its exact mechanism of action is not fully understood. Unlike morphine, narcotoline does not appear to have significant addictive potential, which makes it of interest for further research into non-addictive analgesics.

	==~~See Also~~==		== Synthesis and Isolation ==

	* [[~~Opium~~]]		Narcotoline can be isolated from the opium poppy through a series of extraction and purification processes. It can also be synthesized in the laboratory using various chemical reactions that construct the benzylisoquinoline framework. The synthesis of narcotoline is of interest to researchers studying the biosynthesis of alkaloids in plants.
	* [[~~Opiate~~]]
	* [[~~Benzylisoquinoline~~]]		== Uses and Applications ==
	* [[~~Opioid receptor~~]]
			Currently, narcotoline is not widely used in clinical practice due to its relatively low potency and the availability of more effective analgesics. However, it remains a compound of interest in pharmacological research, particularly in the study of non-addictive pain management options.

			== Related Pages ==

			* [[Papaver somniferum]]
			* [[Morphine]]
			* [[Codeine]]
			* [[Alkaloid]]
			* [[Analgesic]]

	~~[[Category:Opiates]]~~
	[[Category:Alkaloids]]		[[Category:Alkaloids]]
			[[Category:Opium poppy]]
	[[Category:Pharmacology]]		[[Category:Pharmacology]]
	~~{{Pharmacology-stub}}~~
	~~{{Opiates}}~~
	~~{{Alkaloids}}~~

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'''Narcotoline''' is an [[opiate]] alkaloid that is found in [[opium]]. It is a minor constituent of opium, accounting for less than 1% of the total alkaloid content. Despite its low concentration, narcotoline has been the subject of scientific research due to its potential pharmacological properties.

==Chemistry==

Narcotoline is a member of the [[benzylisoquinoline]] class of alkaloids. It is structurally related to other opiate alkaloids such as [[morphine]], [[codeine]], and [[thebaine]]. The chemical structure of narcotoline consists of a benzylisoquinoline core, with additional functional groups that contribute to its pharmacological activity.

==Pharmacology==

The pharmacological properties of narcotoline are not well understood. As an opiate alkaloid, it is believed to interact with the [[opioid receptors]] in the brain, potentially producing analgesic effects. However, the potency and efficacy of narcotoline at these receptors is not known. Further research is needed to fully elucidate the pharmacological activity of this compound.

==Toxicology==

The toxicological profile of narcotoline is also not well characterized. As a minor constituent of opium, it is likely to contribute to the overall toxicity of this substance. However, the specific toxic effects of narcotoline, as well as its lethal dose, are not known.

==History and Legal Status==

Narcotoline was first isolated from opium in the 19th century. Its chemical structure was determined in the early 20th century. Currently, narcotoline is not specifically regulated under international drug control treaties. However, as a constituent of opium, it is indirectly controlled under the provisions that regulate opium and its derivatives.

==See Also==

* [[Opium]]
* [[Opiate]]
* [[Benzylisoquinoline]]
* [[Opioid receptor]]

[[Category:Opiates]]
[[Category:Alkaloids]]
[[Category:Pharmacology]]
{{Pharmacology-stub}}
{{Opiates}}
{{Alkaloids}}

Narcotoline - Revision history

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