https://wikimd.org/index.php?action=history&feed=atom&title=NPS-2143NPS-2143 - Revision history2026-04-26T23:36:56ZRevision history for this page on the wikiMediaWiki 1.44.2https://wikimd.org/index.php?title=NPS-2143&diff=6335222&oldid=prevPrab: CSV import2025-02-20T01:36:23Z<p>CSV import</p>
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<p><b>New page</b></p><div>'''NPS-2143''' is a [[chemical compound]] that acts as a [[calcium]] sensing receptor antagonist. It is primarily used in the field of [[pharmacology]] for research purposes. <br />
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==Chemistry==<br />
NPS-2143, also known as [[calcilytic]], is a small molecule that has the ability to block the effects of extracellular calcium on the calcium-sensing receptor (CaSR). This receptor is a [[G protein-coupled receptor]] that plays a crucial role in maintaining calcium homeostasis in the body.<br />
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==Pharmacology==<br />
NPS-2143 has been shown to increase the secretion of [[parathyroid hormone]] (PTH) in the body. This is due to its ability to inhibit the calcium-sensing receptor, which normally suppresses PTH secretion when calcium levels are high. By blocking this receptor, NPS-2143 allows for increased PTH secretion, which can have various effects on the body, including increased calcium levels in the blood.<br />
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==Clinical Significance==<br />
The ability of NPS-2143 to increase PTH secretion has led to its use in research related to [[osteoporosis]] and other conditions characterized by low bone density. By increasing PTH secretion, NPS-2143 may help to increase bone density and reduce the risk of fractures. However, more research is needed to fully understand the potential benefits and risks of this compound.<br />
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==Potential Side Effects==<br />
As with any pharmacological agent, NPS-2143 has the potential to cause side effects. These may include [[hypercalcemia]], or high calcium levels in the blood, which can lead to various symptoms such as fatigue, nausea, and kidney stones. However, the risk of these side effects is currently unknown and more research is needed.<br />
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==See Also==<br />
* [[Calcium-sensing receptor]]<br />
* [[Parathyroid hormone]]<br />
* [[Osteoporosis]]<br />
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==References==<br />
<references /><br />
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[[Category:Pharmacology]]<br />
[[Category:Chemical compounds]]<br />
[[Category:Calcium]]<br />
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{{pharmacology-stub}}</div>Prab