https://wikimd.org/index.php?action=history&feed=atom&title=NPC1 2026-05-13T10:30:16Z Revision history for this page on the wiki MediaWiki 1.44.2 https://wikimd.org/index.php?title=NPC1&diff=6341176&oldid=prev 2025-02-23T21:07:55Z

<p>CSV import</p> <table style="background-color: #fff; color: #202122;" data-mw="interface"> <col class="diff-marker" /> <col class="diff-content" /> <col class="diff-marker" /> <col class="diff-content" /> <tr class="diff-title" lang="en"> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">← Older revision</td> <td colspan="2" style="background-color: #fff; color: #202122; text-align: center;">Revision as of 21:07, 23 February 2025</td> </tr><tr><td colspan="2" class="diff-lineno" id="mw-diff-left-l25">Line 25:</td> <td colspan="2" class="diff-lineno">Line 25:</td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><br></td></tr> <tr><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td><td class="diff-marker"></td><td style="background-color: #f8f9fa; color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #eaecf0; vertical-align: top; white-space: pre-wrap;"><div>{{stub}}</div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">== NPC1 ==</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;gallery&gt;</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">File:NPC1_location.png|NPC1 location</ins></div></td></tr> <tr><td colspan="2" class="diff-side-deleted"></td><td class="diff-marker" data-marker="+"></td><td style="color: #202122; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;"><div><ins style="font-weight: bold; text-decoration: none;">&lt;/gallery&gt;</ins></div></td></tr> </table>

Prab https://wikimd.org/index.php?title=NPC1&diff=5240495&oldid=prev 2024-02-23T11:00:50Z

<p>CSV import</p> <p><b>New page</b></p><div>&#039;&#039;&#039;NPC1&#039;&#039;&#039; is a protein that in humans is encoded by the &#039;&#039;NPC1&#039;&#039; gene. It is involved in the intracellular trafficking of cholesterol and other lipids and plays a crucial role in the functioning of cells. Mutations in the &#039;&#039;NPC1&#039;&#039; gene are associated with Niemann-Pick disease, type C1, a rare neurodegenerative disorder.<br /> <br /> == Function ==<br /> The &#039;&#039;NPC1&#039;&#039; gene provides instructions for producing a protein that is located in membranes within the cell, including the membranes that surround the cell&#039;s nucleus. The NPC1 protein is involved in the movement of cholesterol and lipids within cells (intracellular trafficking). It plays a crucial role in the normal functioning of cells.<br /> <br /> == Clinical significance ==<br /> Mutations in the &#039;&#039;NPC1&#039;&#039; gene cause Niemann-Pick disease, type C1. This disorder is characterized by the inability of the body to transport cholesterol and other lipids inside cells. This leads to the accumulation of these substances within various tissues of the body, including brain tissue. The accumulation of these substances damages the affected tissues and causes the signs and symptoms of Niemann-Pick disease.<br /> <br /> == See also ==<br /> * [[Niemann-Pick disease]]<br /> * [[Cholesterol]]<br /> * [[Lipid]]<br /> <br /> == References ==<br /> &lt;references /&gt;<br /> <br /> == External links ==<br /> * [[GeneReviews/NCBI/NIH/UW entry on Niemann-Pick disease type C]]<br /> * [[OMIM entries on Niemann-Pick disease type C]]<br /> <br /> [[Category:Genes]]<br /> [[Category:Proteins]]<br /> [[Category:Medical genetics]]<br /> [[Category:Rare diseases]]<br /> <br /> {{stub}}</div>

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